{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:09:09Z","timestamp":1780596549867,"version":"3.54.1"},"reference-count":22,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: ANCA-associated vasculitis (AAV) is a relapsing\u2013remitting systemic disease in which auditory involvement is increasingly recognized as a determinant of quality of life. The objective of this study was to evaluate hearing outcomes during induction therapy in AAV and to assess the applicability of sudden sensorineural hearing loss (SSNHL) criteria for monitoring treatment response. Methods: A prospective study included 27 patients with AAV hospitalized at the Department of Internal Medicine, Nephrology and Dialysis, Military Institute of Medicine\u2013National Research Institute. Audiologic assessment included pure-tone audiometry (including high-frequency audiometry), immittance audiometry, otoacoustic emissions, and auditory brainstem response (ABR). Examinations were performed at baseline (induction phase) and after remission. Hearing outcomes were evaluated using SSNHL criteria defined by the Ministry of Health and Welfare of Japan. Associations between hearing loss and organ involvement were also analyzed. Results: Improvement to normal hearing in pure-tone audiometry was observed in three ears, while deterioration from normal hearing occurred in four ears. No statistically significant differences were found in overall otoacoustic emission responses between baseline and follow-up. A statistically significant association was identified between hearing loss and peripheral nervous system involvement (50.0% vs. 11.1%, p = 0.057). No significant correlations were observed between hearing outcomes and other clinical parameters. Conclusions: SSNHL-based hearing outcome criteria may represent a practical tool for assessing auditory dysfunction and monitoring treatment response in AAV. High-frequency audiometry and structured outcome measures may improve detection of subtle cochlear changes. Further studies with larger cohorts are required to validate these findings and clarify the relationship between systemic disease activity and hearing impairment.<\/jats:p>","DOI":"10.3390\/jcm15114349","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:11:04Z","timestamp":1780593064000},"page":"4349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hearing Outcomes During Induction Therapy in ANCA-Associated Vasculitis: Applicability of Sudden Sensorineural Hearing Loss Criteria"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7743-5522","authenticated-orcid":false,"given":"Micha\u0142 Stanis\u0142aw","family":"Kaczmarczyk","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with Clinical Department of Craniofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4906-8555","authenticated-orcid":false,"given":"Sandra","family":"Krzywdzi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with Clinical Department of Craniofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-9826","authenticated-orcid":false,"given":"Pawe\u0142","family":"Rozbicki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with Clinical Department of Craniofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Usowski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with Clinical Department of Craniofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Jadczak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with Clinical Department of Craniofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Jurkiewicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with Clinical Department of Craniofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-0687","authenticated-orcid":false,"given":"Maria","family":"Sobol","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, 02-901 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-860X","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"Niemczyk","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"G\u0142uch","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksymena","family":"Le\u015bniak","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-349 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10157-012-0768-2","article-title":"Clinical manifestations of granulomatosis with polyangiitis (Wegener\u2019s granulomatosis) in the upper respiratory tract seen by otolaryngologists in Japan","volume":"17","author":"Harabuchi","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0394632015617063","article-title":"Clinic manifestations in granulomatosis with polyangiitis","volume":"29","author":"Greco","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2332\/allergolint.14-RAI-0774","article-title":"Pathogenesis and diagnosis of otitis media with ANCA-associated vasculitis","volume":"63","author":"Yoshida","year":"2014","journal-title":"Allergol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/ard-2022-223764","article-title":"EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update","volume":"83","author":"Hellmich","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1080\/00016489.2017.1297537","article-title":"Nationwide epidemiological survey of idiopathic sudden sensorineural hearing loss in Japan","volume":"137","author":"Kitoh","year":"2017","journal-title":"Acta Otolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1080\/00016489.2017.1296970","article-title":"The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: A nationwide survey in Japan","volume":"137","author":"Okada","year":"2017","journal-title":"Acta Otolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/annrheumdis-2021-221795","article-title":"2022 American college of rheumatology\/European alliance of associations for rheumatology classification criteria for granulomatosis with polyangiitis","volume":"81","author":"Robson","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/annrheumdis-2021-221796","article-title":"2022 American college of rheumatology\/European alliance of associations for rheumatology classification criteria for microscopic polyangiitis","volume":"81","author":"Suppiah","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJMoa0909905","article-title":"Rituximab versus cyclophosphamide for ANCA-associated vasculitis","volume":"363","author":"Stone","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/acr2.11274","article-title":"Comparison of Two Rituximab Induction Regimens for Antineutrophil Cytoplasm Antibody-Associated Vasculitis: Systematic Review and Meta-Analysis","volume":"3","author":"Farhat","year":"2021","journal-title":"ACR Open Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.kint.2023.10.008","article-title":"KDIGO 2024 Clinical Practice Guideline for the Management of Antineutrophil Cytoplasmic Antibody (ANCA)\u2013Associated Vasculitis","volume":"105","author":"Floege","year":"2024","journal-title":"Kidney Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.7326\/0003-4819-150-10-200905190-00004","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial","volume":"150","author":"Harper","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/1529-0131(200104)44:4<912::AID-ANR148>3.0.CO;2-5","article-title":"A disease-specific activity index for Wegener\u2019s granulomatosis: Modification of the Birmingham Vasculitis Activity Score","volume":"44","author":"Stone","year":"2001","journal-title":"Arthritis Rheum."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/14992027.2018.1518598","article-title":"The World Health Organization\u2019s hearing-impairment grading system: An evaluation for unaided communication in age-related hearing loss","volume":"58","author":"Humes","year":"2019","journal-title":"Int. J. Audiol."},{"key":"ref_15","unstructured":"(2024). Acoustics\u2014Statistical Distribution of Hearing Thresholds Related to Age and Gender\u2014Amendment 1: Correction of Parameter Values for Estimating the Hearing Threshold Distribution (Standard No. ISO 7029:2017\/Amd 1:2024). Available online: https:\/\/www.iso.org\/standard\/86637.html."},{"key":"ref_16","first-page":"e29458","article-title":"Sudden Sensorineural Hearing Loss: A Review","volume":"14","author":"Tripathi","year":"2022","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jcma.2018.03.012","article-title":"Modified Siegel\u2019s criteria for sudden sensorineural hearing loss: Reporting recovery outcomes with matched pretreatment hearing grades","volume":"81","author":"Cheng","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.anl.2020.07.004","article-title":"Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan Otological Society","volume":"48","author":"Harabuchi","year":"2021","journal-title":"Auris Nasus Larynx"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kaczmarczyk, M.S., Krzywdzi\u0144ska, S., Rozbicki, P., Usowski, J., Jadczak, M., Jurkiewicz, D., Sobol, M., Niemczyk, S., G\u0142uch, E., and Le\u015bniak, K. (2026). Hearing Involvement in Active ANCA-Associated Vasculitis: The Role of High-Frequency Audiometry in Early Detection. J. Clin. Med., 15.","DOI":"10.3390\/jcm15062147"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/MAO.0000000000000175","article-title":"Reversible cochlear function with ANCA-associated vasculitis initially diagnosed by otologic symptoms","volume":"35","author":"Yoshida","year":"2014","journal-title":"Otol. Neurotol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1002\/lary.25964","article-title":"Focus on audiologic impairment in eosinophilic granulomatosis with polyangiitis","volume":"126","author":"Seccia","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Vainutien\u0117, V., Lesinskas, E., Iva\u0161kien\u0117, T., Mieliauskait\u0117, D., Dadonien\u0117, J., Miltinien\u0117, D., and Iva\u0161ka, J. (2025). Association Between Hearing Loss and Systemic Small-Vessel Vasculitis: Audiological Aspects Across Disease Types. Medicina, 61.","DOI":"10.3390\/medicina61071117"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/11\/4349\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:27:46Z","timestamp":1780594066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/11\/4349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":22,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15114349"],"URL":"https:\/\/doi.org\/10.3390\/jcm15114349","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}