{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:36:04Z","timestamp":1785411364662,"version":"3.56.0"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII) \u201cFondo de Investigaci\u00f3n Sanitaria\u201d","award":["PI17\/PI17\/01683"],"award-info":[{"award-number":["PI17\/PI17\/01683"]}]},{"award":["PI17\/PI17\/01683"],"award-info":[{"award-number":["PI17\/PI17\/01683"]}],"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"publisher"}]},{"name":"FIC"},{"id":[{"id":"https:\/\/ror.org\/00377k374","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"publisher","award":["PT17\/0015\/0040"],"award-info":[{"award-number":["PT17\/0015\/0040"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PT17\/0015\/0040"],"award-info":[{"award-number":["PT17\/0015\/0040"]}],"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Hypoattenuated leaflet thrombosis (HALT) is a frequent finding after transcatheter aortic valve replacement (TAVR). Although high residual platelet reactivity (HPR) increases thrombotic risk after coronary stent implantation, its role in HALT remains unclear. This study aimed to determine the incidence and predictors of HALT in TAVR patients treated with dual antiplatelet therapy, focusing on the impact of HPR. Methods: This was a prospective, multicenter observational study. Between June 2018 and February 2022 patients with symptomatic severe aortic stenosis undergoing successful TAVR and treated with dual antiplatelet therapy for 3 months were included. Platelet reactivity was assessed 1\u20133 months post-TAVR using either VerifyNow (72%) or the Multiplate Analyzer (28%). HALT was evaluated using contrast-enhanced multidetector computed tomography. Results: A total of 169 patients were included (mean age 81.5 \u00b1 5 years; 51% female). The incidence of HALT was 22%. Independent predictors of HALT were self-expanding valve (OR 3.05; 95% CI, 1.30\u20137.14; p = 0.010). Protective factors included larger prosthesis size (OR 0.78; 95% CI, 0.65\u20130.93; p = 0.007), statin-treated dyslipidemia (OR 0.37; 95% CI, 0.16\u20130.88; p = 0.024), and higher creatinine clearance (OR 0.98; 95% CI, 0.96\u20131.00; p = 0.035). HALT incidence was similar in patients with and without HPR (23.7% vs. 33.6%; p = 0.29). No differences in clinical outcomes were observed at 1 year. Conclusions: HALT occurred in nearly one-quarter of TAVR patients treated with dual antiplatelet therapy and was unrelated to platelet reactivity. Valve characteristics, renal function, and statin-treated dyslipidemia were associated with HALT, highlighting the multifactorial nature of its development.<\/jats:p>","DOI":"10.3390\/jcm15124469","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:33:44Z","timestamp":1781073224000},"page":"4469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoattenuated Leaflet Thickening After TAVR: Incidence, Predictors, and the Role of Platelet Reactivity: A Prospective Multicenter Observational Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-8677","authenticated-orcid":false,"given":"Pilar","family":"Jimenez-Quevedo","sequence":"first","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-9260","authenticated-orcid":false,"given":"Carolina","family":"Espejo-Paeres","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-5286","authenticated-orcid":false,"given":"Francesco","family":"Spione","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Cl\u00ednic, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-943X","authenticated-orcid":false,"given":"Breda","family":"Hennessey","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"McInerney","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-8885","authenticated-orcid":false,"given":"Luis","family":"Marroquin","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa. Ar\u00e1nzazu","family":"Ortega-Pozzi","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Tirado-Conte","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Macaya","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Cabeza","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2532-0296","authenticated-orcid":false,"given":"Irene","family":"Mart\u00edn Lores","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-4029","authenticated-orcid":false,"given":"Pablo","family":"Salinas","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-3102","authenticated-orcid":false,"given":"Ivan","family":"Nu\u00f1ez-Gil","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n","family":"Mej\u00eda-Renter\u00eda","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-1910","authenticated-orcid":false,"given":"Antonio","family":"Fern\u00e1ndez-Ortiz","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-3481","authenticated-orcid":false,"given":"Jose Juan","family":"G\u00f3mez De Diego","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Perez-Villacastin","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health 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Cl\u00ednic, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-6020","authenticated-orcid":false,"given":"Eduardo","family":"Pozo Osinalde","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinico San Carlos University Hospital, Health Research Institute of Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/eurheartj\/eht316","article-title":"Cusp thrombosis after transcatheter aortic valve replacement detected by computed tomography and echocardiography","volume":"34","author":"Pache","year":"2013","journal-title":"Eur. 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Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4469\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:19:56Z","timestamp":1781324396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15124469"],"URL":"https:\/\/doi.org\/10.3390\/jcm15124469","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]}}}