{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:45:58Z","timestamp":1793335558158,"version":"4.5.0"},"reference-count":77,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Multivessel coronary artery disease is observed in a substantial proportion of patients presenting with ST-segment elevation myocardial infarction (STEMI) and identifies a higher-risk phenotype characterized by larger atherosclerotic burden, recurrent ischemic events, and greater need for subsequent revascularization. Over the past decade, randomized evidence has progressively shifted the interventional paradigm from culprit-lesion-only primary percutaneous coronary intervention (PCI) toward complete revascularization in hemodynamically stable STEMI patients with suitable non-culprit lesions. Nevertheless, several clinically relevant questions remain unresolved, including the optimal criteria for selecting non-culprit lesions, the relative value of angiography, coronary physiology, and intracoronary imaging, the timing of complete revascularization, and the management of patients presenting with cardiogenic shock. Angiography-guided complete revascularization has the strongest evidence base, while physiology-guided approaches may reduce unnecessary PCI but have not demonstrated superiority over angiography-guided strategies in direct randomized comparisons. Intracoronary imaging offers unique information on plaque vulnerability and PCI optimization, although dedicated outcome trials in STEMI remain limited. The timing of complete revascularization has also evolved, with contemporary trials supporting early treatment in selected stable patients but not establishing a universal immediate strategy. This review summarizes current evidence, unresolved controversies, and emerging directions regarding strategies and timing of complete revascularization in STEMI patients with multivessel disease.<\/jats:p>","DOI":"10.3390\/jcm15124667","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:27:21Z","timestamp":1781666841000},"page":"4667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Strategies and Timing of Complete Revascularization in STEMI Patients with Multivessel Coronary Artery Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-910X","authenticated-orcid":false,"given":"Domenico Simone","family":"Castiello","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy"},{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rocca","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7499-3511","authenticated-orcid":false,"given":"Letizia Rosa","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-0510","authenticated-orcid":false,"given":"Carmen Anna Maria","family":"Spaccarotella","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-3031","authenticated-orcid":false,"given":"Alberto","family":"Polimeni","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"},{"name":"Division of Interventional Cardiology, Annunziata Hospital, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Chiatto","sequence":"additional","affiliation":[{"name":"Annunziata Hospital, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3213-4436","authenticated-orcid":false,"given":"Antonio","family":"Curcio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-7127","authenticated-orcid":false,"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Indolfi","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Cuore e Circolazione, Italian Society of Cardiology, 00198 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref_1","unstructured":"GBD 2017 Causes of Death Collaborators (2018). Global, Regional, and National Age-Sex-Specific Mortality for 282 Causes of Death in 195 Countries and Territories, 1980\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1736\u20131788."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1093\/eurheartj\/ehu299","article-title":"Cardiovascular Disease in Europe 2014: Epidemiological Update","volume":"35","author":"Nichols","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCULATIONAHA.109.192666","article-title":"Executive Summary: Heart Disease and Stroke Statistics\u20142010 Update: A Report from the American Heart Association","volume":"121","author":"Adams","year":"2010","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the Management of Chronic Coronary Syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the Management of Acute Coronary Syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/CIR.0000000000000336","article-title":"2015 ACC\/AHA\/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients with ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF\/AHA\/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF\/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions","volume":"133","author":"Levine","year":"2016","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(06)68148-8","article-title":"Comparison of Primary and Facilitated Percutaneous Coronary Interventions for ST-Elevation Myocardial Infarction: Quantitative Review of Randomised Trials","volume":"367","author":"Keeley","year":"2006","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1001\/jama.2014.15095","article-title":"Extent, Location, and Clinical Significance of Non-Infarct-Related Coronary Artery Disease among Patients with ST-Elevation Myocardial Infarction","volume":"312","author":"Park","year":"2014","journal-title":"JAMA"},{"key":"ref_9","first-page":"905","article-title":"Etiologies, Trends, and Predictors of Readmission in ST-Elevation Myocardial Infarction Patients Undergoing Multivessel Percutaneous Coronary Intervention","volume":"94","author":"Tripathi","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.amjcard.2019.04.048","article-title":"Long-Term Safety and Efficacy of Staged Percutaneous Coronary Intervention for Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Coronary Disease","volume":"124","author":"Cui","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.acvd.2017.08.005","article-title":"Immediate Complete Revascularization in Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Disease Treated by Primary Percutaneous Coronary Intervention: Insights from the ORBI Registry","volume":"111","author":"Pimor","year":"2018","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/eurheartj\/ehq410","article-title":"How to Treat Patients with ST-Elevation Acute Myocardial Infarction and Multi-Vessel Disease?","volume":"32","author":"Widimsky","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1136\/hrt.2005.086058","article-title":"Long-term Impact of Multivessel Disease on Cause-specific Mortality after ST Elevation Myocardial Infarction Treated with Reperfusion Therapy","volume":"92","author":"Timmer","year":"2006","journal-title":"Heart"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Forzano, I., Florimonte, D., Narciso, V., Canonico, M.E., Castiello, D.S., Manzi, L., Cristiano, S., Spinelli, A., Vallone, D.M., and D\u2019Alconzo, D. (2025). Optimal Medical Therapy Targeting Lipids and Inflammation for Secondary Prevention in Patients Undergoing Percutaneous Coronary Intervention. J. Clin. Med., 14.","DOI":"10.3390\/jcm14238334"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/eurheartj\/ehz520","article-title":"Relationship between Coronary Plaque Morphology of the Left Anterior Descending Artery and 12 Months Clinical Outcome: The CLIMA Study","volume":"41","author":"Prati","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJMoa1002358","article-title":"A Prospective Natural-History Study of Coronary Atherosclerosis","volume":"364","author":"Stone","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e008768","DOI":"10.1161\/CIRCINTERVENTIONS.119.008768","article-title":"Nonculprit Lesion Plaque Morphology in Patients with ST-Segment-Elevation Myocardial Infarction: Results from the COMPLETE Trial Optical Coherence Tomography Substudys","volume":"13","author":"Mehta","year":"2020","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.jcin.2015.08.013","article-title":"Comparative Effectiveness and Safety of New-Generation Versus Early-Generation Drug-Eluting Stents According to Complexity of Coronary Artery Disease: A Patient-Level Pooled Analysis of 6,081 Patients","volume":"8","author":"Piccolo","year":"2015","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jjcc.2022.09.001","article-title":"Radial versus Femoral Access in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: A Propensity-Matched Analysis from Real-World Data of the K-ACTIVE Registry","volume":"81","author":"Mori","year":"2023","journal-title":"J. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1051","DOI":"10.4244\/EIJ-D-24-00992","article-title":"Antithrombotic Therapy in Complex Percutaneous Coronary Intervention","volume":"21","author":"Castiello","year":"2025","journal-title":"EuroIntervention"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0140-6736(23)02454-6","article-title":"Intravascular Imaging-Guided Coronary Drug-Eluting Stent Implantation: An Updated Network Meta-Analysis","volume":"403","author":"Stone","year":"2024","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/j.jcin.2023.07.043","article-title":"Complete Percutaneous Coronary Revascularization in Acute Coronary Syndromes With Multivessel Coronary Disease: A Systematic Review","volume":"16","author":"Faro","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","article-title":"PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock","volume":"377","author":"Thiele","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jacc.2025.01.029","article-title":"Invasive vs Conservative Management of Patients With Chronic Total Occlusion: Results From the ISCHEMIA Trial","volume":"85","author":"Bangalore","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4244\/EIJ-D-20-00957","article-title":"Completeness of Revascularisation in Acute Coronary Syndrome Patients with Multivessel Disease","volume":"17","author":"Paradies","year":"2021","journal-title":"EuroIntervention"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0735-1097(02)02049-1","article-title":"Exaggeration of Nonculprit Stenosis Severity during Acute Myocardial Infarction: Implications for Immediate Multivessel Revascularization","volume":"40","author":"Hanratty","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/hrt.2009.177162","article-title":"A Randomised Trial of Target-Vessel versus Multi-Vessel Revascularisation in ST-Elevation Myocardial Infarction: Major Adverse Cardiac Events during Long-Term Follow-Up","volume":"96","author":"Politi","year":"2010","journal-title":"Heart"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJMoa1305520","article-title":"PRAMI Investigators Randomized Trial of Preventive Angioplasty in Myocardial Infarction","volume":"369","author":"Wald","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jacc.2014.12.038","article-title":"Randomized Trial of Complete versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease: The CvLPRIT Trial","volume":"65","author":"Gershlick","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1056\/NEJMoa1907775","article-title":"Complete Revascularization with Multivessel PCI for Myocardial Infarction","volume":"381","author":"Mehta","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/S0140-6736(25)02170-1","article-title":"Complete versus Culprit Lesion-Only Revascularisation for Acute Myocardial Infarction (Complete Revascularisation Trialists\u2019 Collaboration): An Individual Patient Data Meta-Analysis of Randomised Trials","volume":"406","author":"Mehta","year":"2025","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1001\/jamacardio.2019.2138","article-title":"Temporal Changes in Coronary Hyperemic and Resting Hemodynamic Indices in Nonculprit Vessels of Patients With ST-Segment Elevation Myocardial Infarction","volume":"4","author":"Janssens","year":"2019","journal-title":"JAMA Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0140-6736(15)60648-1","article-title":"Complete Revascularisation versus Treatment of the Culprit Lesion Only in Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Disease (DANAMI-3\u2014PRIMULTI): An Open-Label, Randomised Controlled Trial","volume":"386","author":"Helqvist","year":"2015","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJMoa1701067","article-title":"Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction","volume":"376","author":"Smits","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJMoa2104650","article-title":"Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction","volume":"385","author":"Puymirat","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/eurheartj\/ehac763","article-title":"Fractional Flow Reserve versus Angiography-Guided Strategy in Acute Myocardial Infarction with Multivessel Disease: A Randomized Trial","volume":"44","author":"Lee","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJMoa2314149","article-title":"FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction","volume":"390","author":"Mogensen","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJMoa2300468","article-title":"Complete or Culprit-Only PCI in Older Patients with Myocardial Infarction","volume":"389","author":"Biscaglia","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa1616540","article-title":"Instantaneous Wave-Free Ratio versus Fractional Flow Reserve to Guide PCI","volume":"376","author":"Christiansen","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJMoa2512918","article-title":"Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction","volume":"394","author":"Nijveldt","year":"2026","journal-title":"N. Engl. J. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e35687","DOI":"10.1097\/MD.0000000000035687","article-title":"Comprehensive Review of ST-Segment Elevation Myocardial Infarction: Understanding Pathophysiology, Diagnostic Strategies, and Current Treatment Approaches","volume":"102","author":"Elendu","year":"2023","journal-title":"Medicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jamacardio.2019.0275","article-title":"Coronary Atherosclerotic Phenotype and Plaque Healing in Patients With Recurrent Acute Coronary Syndromes Compared With Patients With Long-Term Clinical Stability: An In Vivo Optical Coherence Tomography Study","volume":"4","author":"Vergallo","year":"2019","journal-title":"JAMA Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1093\/eurheartj\/ehy285","article-title":"Clinical Use of Intracoronary Imaging. Part 1: Guidance and Optimization of Coronary Interventions. An Expert Consensus Document of the European Association of Percutaneous Cardiovascular Interventions","volume":"39","author":"Mintz","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1093\/eurheartj\/ehz332","article-title":"Clinical Use of Intracoronary Imaging. Part 2: Acute Coronary Syndromes, Ambiguous Coronary Angiography Findings, and Guiding Interventional Decision-Making: An Expert Consensus Document of the European Association of Percutaneous Cardiovascular Interventions","volume":"40","author":"Johnson","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Karamasis, G.V., Varlamos, C., Benetou, D.-R., Kalogeropoulos, A.S., Keeble, T.R., Tsigkas, G., and Xenogiannis, I. (2023). The Usefulness of Intracoronary Imaging in Patients with ST-Segment Elevation Myocardial Infarction. J. Clin. Med., 12.","DOI":"10.3390\/jcm12185892"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1093\/eurheartj\/ehab433","article-title":"Thin-Cap Fibroatheroma Predicts Clinical Events in Diabetic Patients with Normal Fractional Flow Reserve: The COMBINE OCT-FFR Trial","volume":"42","author":"Kedhi","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0140-6736(21)00249-X","article-title":"Identification of Vulnerable Plaques and Patients by Intracoronary Near-Infrared Spectroscopy and Ultrasound (PROSPECT II): A Prospective Natural History Study","volume":"397","author":"Erlinge","year":"2021","journal-title":"Lancet"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.4244\/EIJ-D-24-00720","article-title":"Functional or Anatomical Assessment of Non-Culprit Lesions in Acute Myocardial Infarction","volume":"21","author":"Xu","year":"2025","journal-title":"EuroIntervention"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jacasi.2024.04.001","article-title":"Management of Coronary Vulnerable Plaque With Medical Therapy or Local Preventive Percutaneous Coronary Intervention","volume":"4","author":"Kim","year":"2024","journal-title":"JACC Asia"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Forzano, I., Narciso, V., Canonico, M.E., Castiello, D.S., Florimonte, D., Manzi, L., Semplice, F., Vallone, D.M., Cristiano, S., and Spinelli, A. (2026). Optimal Medical Therapy Targeting Metabolic Status for Secondary Prevention in Patients Undergoing Percutaneous Coronary Intervention. J. Clin. Med., 15.","DOI":"10.3390\/jcm15031108"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2147\/PPA.S356653","article-title":"Patient Adherence to Therapy After Myocardial Infarction: A Scoping Review","volume":"16","author":"Zorina","year":"2022","journal-title":"Patient Prefer. Adherence"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/S0140-6736(24)00413-6","article-title":"Preventive Percutaneous Coronary Intervention versus Optimal Medical Therapy Alone for the Treatment of Vulnerable Atherosclerotic Coronary Plaques (PREVENT): A Multicentre, Open-Label, Randomised Controlled Trial","volume":"403","author":"Park","year":"2024","journal-title":"Lancet"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jtcvs.2013.10.019","article-title":"Standardizing Definitions for Hybrid Coronary Revascularization","volume":"147","author":"Harskamp","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.4244\/EIJ-E-23-00045","article-title":"Complete Revascularisation Should Be Immediate in STEMI: Pros and Cons","volume":"20","author":"Kastrati","year":"2024","journal-title":"EuroIntervention"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.jacc.2019.09.051","article-title":"Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction: COMPLETE Trial","volume":"74","author":"Wood","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(23)00351-3","article-title":"Immediate versus Staged Complete Revascularisation in Patients Presenting with Acute Coronary Syndrome and Multivessel Coronary Disease (BIOVASC): A Prospective, Open-Label, Non-Inferiority, Randomised Trial","volume":"401","author":"Diletti","year":"2023","journal-title":"Lancet"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa2307823","article-title":"Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction","volume":"389","author":"Varbella","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0140-6736(25)01529-6","article-title":"Immediate versus Staged Complete Revascularisation during Index Admission in Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Disease (OPTION-STEMI): A Multicentre, Non-Inferiority, Open-Label, Randomised Trial","volume":"406","author":"Kim","year":"2025","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Elbahloul, M.A., Ramadan, S., Labeeb, E.E., Aldalahmeh, S., Mousa, A.I.A., Elazab, A., Mohamed, A.N., Elashery, A., El-Hamdani, M.O., and Lavie, C.J. (2026). Timing of Complete Revascularization in Patients With STEMI and Multivessel Disease: An Updated Meta-Analysis of Randomized Clinical Trials. Circ. Cardiovasc. Interv., e016601.","DOI":"10.1161\/CIRCINTERVENTIONS.126.016601"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/eurheartj\/ehz363","article-title":"Management of Cardiogenic Shock Complicating Myocardial Infarction: An Update 2019","volume":"40","author":"Thiele","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e021061","DOI":"10.1161\/JAHA.121.021061","article-title":"Fifteen-Year Trends in Incidence of Cardiogenic Shock Hospitalization and In-Hospital Mortality in the United States","volume":"10","author":"Osman","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/S0735-1097(03)01050-7","article-title":"Percutaneous Coronary Intervention for Cardiogenic Shock in the SHOCK Trial","volume":"42","author":"Webb","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","article-title":"Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock","volume":"390","author":"Jensen","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.jcin.2025.07.035","article-title":"Percutaneous Coronary Intervention in Multivessel Disease and Infarct-Related Cardiogenic Shock: A DanGer Shock Substudy","volume":"18","author":"Marquard","year":"2025","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e1371","DOI":"10.4244\/EIJ-D-21-00904","article-title":"Antiplatelet Therapy after Percutaneous Coronary Intervention","volume":"17","author":"Angiolillo","year":"2022","journal-title":"EuroIntervention"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ahj.2022.10.006","article-title":"P2Y12 Inhibitors Monotherapy in Patients Undergoing Complex vs Non-Complex Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials","volume":"255","author":"Oliva","year":"2023","journal-title":"Am. Heart J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4244\/EIJ-D-24-00757","article-title":"Pharmacodynamic Effects of Cangrelor in Patients with Acute or Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention: The POMPEII Registry","volume":"21","author":"Gargiulo","year":"2025","journal-title":"EuroIntervention"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gargiulo, G., Narciso, V., Forzano, I., Sperandeo, L., Castiello, D.S., Simonetti, F., Manzi, L., Florimonte, D., Canonico, M.E., and Avvedimento, M. (2026). Pharmacodynamic Effects of Cangrelor in Patients with or without STEMI Undergoing Percutaneous Coronary Intervention: Insights from the POMPEII Study. Eur. Heart J. Acute Cardiovasc. Care, zuag056.","DOI":"10.1093\/ehjacc\/zuag056"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jcin.2025.01.451","article-title":"Cangrelor During Percutaneous Coronary Intervention in Patients With Cardiogenic Shock or Cardiac Arrest","volume":"18","author":"Emilsson","year":"2025","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.jacc.2016.07.760","article-title":"Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI","volume":"68","author":"Giustino","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e70049","DOI":"10.1002\/clc.70049","article-title":"Rationale and Design of Dual Antiplatelet Therapy in Patients with Coronary Multi-Vessel Disease (DAPT-MVD): A Multicenter, Randomized, Controlled Trial","volume":"47","author":"Tian","year":"2024","journal-title":"Clin. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/j.jacc.2025.08.040","article-title":"Personalized or Standard Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: The PARTHENOPE Randomized Trial","volume":"86","author":"Piccolo","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Castiello, D.S., Buongiorno, F., Manzi, L., Narciso, V., Forzano, I., Florimonte, D., Sperandeo, L., Canonico, M.E., Avvedimento, M., and Paolillo, R. (2025). Procedural and Antithrombotic Therapy Optimization in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Narrative Review. J. Cardiovasc. Dev. Dis., 12.","DOI":"10.3390\/jcdd12040142"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ahj.2025.02.012","article-title":"Functional Coronary Angiography to Indicate and Guide Revascularization in STEMI Patients with Multivessel Disease: Rationale and Design of the AIR-STEMI Trial","volume":"284","author":"Erriquez","year":"2025","journal-title":"Am. Heart J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"431","DOI":"10.23736\/S2724-5683.22.06144-0","article-title":"OCT Guided vs. COmplete Pci in patieNts with sT Segment Elevation myocArdial infarCtion and mulTivessel Disease: OCT-CONTACT RCT","volume":"71","author":"Iannaccone","year":"2023","journal-title":"Minerva Cardiol. Angiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107352","DOI":"10.1016\/j.ahj.2026.107352","article-title":"Staged Interventional Strategies for Acute ST-Segment Elevation Myocardial Infarction Patient with Multivessel Disease: Rationale and Design of a Multicenter, Randomized STAGED Trial","volume":"295","author":"Chen","year":"2026","journal-title":"Am. Heart J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4667\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:12:40Z","timestamp":1782187960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":77,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15124667"],"URL":"https:\/\/doi.org\/10.3390\/jcm15124667","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}