{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:52:54Z","timestamp":1781772774008,"version":"3.54.5"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The progression of myopia in the pediatric population is currently highly prevalent. Thus, there is a need to look for new, effective methods that might suppress this pathological process. It not only affects visual comfort but also increases the risk of developing further ocular complications. The aim of the study is to review the literature and summarize contemporary methods for preventing the progression of myopia in children. The review is based on publications available on PubMed from the past 17 years, supplemented by the current literature on advanced digital technologies in ophthalmology. This article highlights that among other treatments such as orthokeratology, low-dose atropine or specialized lenses, there are also further beneficial options, including increased outdoor time, reduced screen time or the implementation of the latest medical innovations. The results indicate that defocus spectacle lenses may reduce myopia progression by approximately 50\u201367%, while orthokeratology has been associated with about a 46% reduction in axial elongation. Although there is a broad spectrum of therapeutic strategies, it is essential to develop novel approaches to myopia prevention in children to improve their quality of life from childhood into adulthood.<\/jats:p>","DOI":"10.3390\/jcm15124734","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:33:54Z","timestamp":1781768034000},"page":"4734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modern Methods for Preventing the Progression of Myopia in Children"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-4394","authenticated-orcid":false,"given":"Zofia","family":"Pniakowska","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-549 Lodz, Poland"},{"name":"Optegra Eye Clinic, 90-127 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0305-1414","authenticated-orcid":false,"given":"Sonia","family":"Czarkowska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7090-259X","authenticated-orcid":false,"given":"Natasza","family":"Kurys","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Or\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Jurowski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Rehabilitation, Medical University of Lodz, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41433-021-01805-6","article-title":"Myopia prediction: A systematic review","volume":"36","author":"Han","year":"2022","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Surico, P.L., Parmar, U.P.S., Singh, R.B., Farsi, Y., Musa, M., Maniaci, A., Lavalle, S., D\u2019Esposito, F., Gagliano, C., and Zeppieri, M. (2024). Myopia in Children: Epidemiology, Genetics, and Emerging Therapies for Treatment and Prevention. Children, 11.","DOI":"10.3390\/children11121446"},{"key":"ref_3","first-page":"CD004916","article-title":"Interventions to slow progression of myopia in children","volume":"1","author":"Walline","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI Prevention of Myopia and Its Progression","volume":"62","author":"Jonas","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1001\/jama.2015.10803","article-title":"Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China: A Randomized Clinical Trial","volume":"314","author":"He","year":"2015","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.ophtha.2017.12.011","article-title":"Myopia Prevention and Outdoor Light Intensity in a School-Based Cluster Randomized Trial","volume":"125","author":"Wu","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_7","first-page":"1482","article-title":"Review: Myopia control strategies recommendations from the 2018 WHO\/IAPB\/BHVI Meeting on Myopia","volume":"104","author":"Ang","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.ophtha.2012.04.020","article-title":"The association between time spent outdoors and myopia in children and adolescents: A systematic review and meta-analysis","volume":"119","author":"Sherwin","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.ophtha.2022.06.024","article-title":"Time Outdoors in Reducing Myopia: A School-Based Cluster Randomized Trial with Objective Monitoring of Outdoor Time and Light Intensity","volume":"129","author":"He","year":"2022","journal-title":"Ophthalmology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1001\/jamapediatrics.2022.3542","article-title":"Effect of Text Messaging Parents of School-Aged Children on Outdoor Time to Control Myopia: A Randomized Clinical Trial","volume":"176","author":"Li","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000501937","article-title":"Significance of Outdoor Time for Myopia Prevention: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials","volume":"63","author":"Cao","year":"2020","journal-title":"Ophthalmic Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/bjophthalmol-2019-314675","article-title":"How does spending time outdoors protect against myopia? A review","volume":"104","author":"Lingham","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Huang, H.M., Chang, D.S., and Wu, P.C. (2015). The Association between Near Work Activities and Myopia in Children-A Systematic Review and Meta-Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140419"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e806","DOI":"10.1016\/S2589-7500(21)00135-7","article-title":"Association between digital smart device use and myopia: A systematic review and meta-analysis","volume":"3","author":"Foreman","year":"2021","journal-title":"Lancet Digit. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105988","DOI":"10.1016\/j.ypmed.2020.105988","article-title":"The impact of computer use on myopia development in childhood: The Generation R study","volume":"132","author":"Enthoven","year":"2020","journal-title":"Prev. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archophthalmol.2009.105","article-title":"Associations between near work, outdoor activity, and myopia among adolescent students in rural China: The Xichang Pediatric Refractive Error Study report no. 2","volume":"127","author":"Lu","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/cxo.13092","article-title":"Smartphone use as a possible risk factor for myopia","volume":"104","author":"Mccrann","year":"2021","journal-title":"Clin. Exp. Optom."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/OPX.0b013e3182198792","article-title":"Font size and viewing distance of handheld smart phones","volume":"88","author":"Bababekova","year":"2011","journal-title":"Optom. Vis. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.exer.2013.04.018","article-title":"Time outdoors and the prevention of myopia","volume":"114","author":"French","year":"2013","journal-title":"Exp. Eye Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jamaophthalmol.2020.6239","article-title":"Progression of Myopia in School-Aged Children After COVID-19 Home Confinement","volume":"139","author":"Wang","year":"2021","journal-title":"JAMA Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ajo.2020.07.034","article-title":"Digital Screen Time During the COVID-19 Pandemic: Risk for a Further Myopia Boom?","volume":"223","author":"Wong","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Tian, S., Zou, D., Zhang, H., and Pan, C.W. (2022). Screen time and health issues in Chinese school-aged children and adolescents: A systematic review and meta-analysis. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-13155-3"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, H., Lam, C.S.Y., Tang, W.C., Leung, M., Qi, H., Lee, P.H., and To, C.H. (2022). Myopia Control Effect Is Influenced by Baseline Relative Peripheral Refraction in Children Wearing Defocus Incorporated Multiple Segments (DIMS) Spectacle Lenses. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092294"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1167\/iovs.15-17200","article-title":"Relative Peripheral Hyperopia Does Not Predict Development and Progression of Myopia in Children","volume":"56","author":"Atchison","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1167\/iovs.61.5.53","article-title":"Defocus Incorporated Multiple Segments Spectacle Lenses Changed the Relative Peripheral Refraction: A 2-Year Randomized Clinical Trial","volume":"61","author":"Zhang","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.18240\/ijo.2025.04.20","article-title":"Myopia control efficacy of peripheral defocus modifying spectacle lenses in children and adolescents: A Meta-analysis","volume":"18","author":"Fan","year":"2025","journal-title":"Int. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jamaophthalmol.2022.0401","article-title":"Spectacle Lenses with Aspherical Lenslets for Myopia Control vs. Single-Vision Spectacle Lenses: A Randomized Clinical Trial","volume":"140","author":"Bao","year":"2022","journal-title":"JAMA Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1136\/bjophthalmol-2018-313739","article-title":"Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: A 2-year randomised clinical trial","volume":"104","author":"Lam","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/opo.13163","article-title":"Dual-focus contact lenses for myopia control modify central retinal electrophysiology in humans","volume":"43","author":"Turnbull","year":"2023","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/opo.13042","article-title":"Efficacy of contact lenses for myopia control: Insights from a randomised, contralateral study design","volume":"42","author":"Weng","year":"2022","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/ICL.0000000000001185","article-title":"Power Profiles of Different Myopia Control Soft Contact Lenses","volume":"51","author":"Batres","year":"2025","journal-title":"Eye Contact Lens Sci. Clin. Pract."},{"key":"ref_32","first-page":"e94217","article-title":"Efficacy of Contact Lens-Based Interventions in Slowing Myopia Progression in Children: A Systematic Review","volume":"17","author":"Alagsam","year":"2025","journal-title":"Cureus"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100375","DOI":"10.1016\/j.clinsp.2024.100375","article-title":"Low-level red-light therapy for myopia control in children: A systematic review and meta-analysis","volume":"79","author":"Amaral","year":"2024","journal-title":"Clinics"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fan, H., Yu, J., Jiang, A., Wei, Q., Zhang, X., Xie, A., and Duan, J. (2025). Effects of repeated low-level red light therapy on myopia progression in children: A systematic review and meta-analysis. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1640403"},{"key":"ref_35","unstructured":"Shi, D., Liu, B., Tian, Z., Wu, Y., Yang, J., Chen, R., Yang, B., Xiao, O., and He, M. (2025). Fundus2Globe: Generative AI-Driven 3D Digital Twins for Personalized Myopia Management. arXiv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1136\/bjo-2021-320920","article-title":"Oral administration of caffeine metabolite 7-methylxanthine is associated with slowed myopia progression in Danish children","volume":"107","author":"Trier","year":"2023","journal-title":"Br. J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/iovs.67.1.15","article-title":"Inhibition of Retinal AdoRA2a Activity Attenuates Myopia Progression","volume":"67","author":"Liu","year":"2026","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ebiom.2016.12.007","article-title":"Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression","volume":"15","author":"Torii","year":"2017","journal-title":"eBioMedicine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e002044","DOI":"10.1136\/bmjophth-2024-002044","article-title":"Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: Study protocol for a randomised controlled trial (phase 1)","volume":"10","author":"Hon","year":"2025","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.exer.2013.02.007","article-title":"An updated view on the role of dopamine in myopia","volume":"114","author":"Feldkaemper","year":"2013","journal-title":"Exp. Eye Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4734\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:11:01Z","timestamp":1781770261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15124734"],"URL":"https:\/\/doi.org\/10.3390\/jcm15124734","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}