{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:40:19Z","timestamp":1785404419599,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009879","name":"Regione Emilia-Romagna","doi-asserted-by":"crossref","award":["AVIN code 22 MIPE"],"award-info":[{"award-number":["AVIN code 22 MIPE"]}],"id":[{"id":"10.13039\/501100009879","id-type":"DOI","asserted-by":"crossref"}]},{"award":["AVIN code 22 MIPE"],"award-info":[{"award-number":["AVIN code 22 MIPE"]}],"id":[{"id":"https:\/\/ror.org\/02k57f568","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Healthcare-associated bloodstream infections (HABSIs) are among the main categories of nosocomial infections. This analysis aims to identify the clinical characteristics of patients in the emergency department (ED) who will develop a HABSI during their hospital stay. Methods: Main outcome measures were HABSI and the cumulative survival rate at 30 days. The features tested in a logistic model were age, sex, vitals by the National Early Warning Score (NEWS), priority levels, main complaints, comorbidities by the Charlson Comorbidity Index (CCI), trauma-related disease, main diagnosis and ED length of stay. Results: In 414 (2.3%) out of 18,304 patients, aged 75 (16) years, mean (SD), a diagnosis of HABSI was recorded. HABSIs occurred in subjects with main diagnosis of diseases of the respiratory system (N = 116; 28.0%), digestive system (N = 72; 17.4%), and circulatory system (N = 68; 16.4%). The main key clinical features selected by the logistic model were: NEWS &gt; 6, diagnosis of neoplasms, CCI &gt; 4, and diagnosis of diseases of the digestive system. The ROC curve for the HABSI risk score was 0.703 \u00b1 0.027 in predicting the outcome, (sensitivity 79%, specificity 51%, at optimal cut-off score). The overall hazard mortality risk was twofold higher in patients with HABSIs (hazard ratio: 2.319; 95% confidence interval: 1.871\u20132.875; p-value: &lt;0.001). The overall 30-day survival rate was lower among patients with HABSIs (33%) vs. non-HABSI patients (62%). Conclusions: A group of main clinical features in subjects without suspect of infectious disease in the ED are associated with HABSIs. These features negatively impact survival rate during hospital stays.<\/jats:p>","DOI":"10.3390\/jcm15124771","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:04:04Z","timestamp":1781874244000},"page":"4771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Healthcare-Associated Bloodstream Infections in Subjects Hospitalised from the Emergency Department for Non-Infectious Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-4638","authenticated-orcid":false,"given":"Andrea","family":"Fabbri","sequence":"first","affiliation":[{"name":"Emergency Department, Local Health Agency of Romagna, Presidio Ospedaliero Morgagni-Pierantoni, Via C Forlanini 34, 47121 Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9087-2807","authenticated-orcid":false,"given":"Ayca Begum","family":"Tascioglu","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, University of Bologna, Mura Anteo Zamboni 7, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6925-5712","authenticated-orcid":false,"given":"Flavio","family":"Bertini","sequence":"additional","affiliation":[{"name":"Department of Mathematical, Physical and Computer Sciences, University of Parma, Parco Area delle Scienze 53\/A, 43124 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Benazzi","sequence":"additional","affiliation":[{"name":"Emergency Department, Local Health Agency of Romagna, Presidio Ospedaliero Morgagni-Pierantoni, Via C Forlanini 34, 47121 Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Martello","sequence":"additional","affiliation":[{"name":"Health Directorate of Local Health Agency of Romagna, Presidio Ospedaliero Morgagni-Pierantoni, Via C Forlanini 34, 47121 Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Montesi","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, University of Bologna, Mura Anteo Zamboni 7, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1007\/s00134-020-06106-2","article-title":"Epidemiology and Burden of Sepsis Acquired in Hospitals and Intensive Care Units: A Systematic Review and Meta-Analysis","volume":"46","author":"Markwart","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_2","unstructured":"(2025, March 13). 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