{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:46:15Z","timestamp":1782452775812,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Peripheral pulsed radiofrequency (PRF) is a minimally invasive option for trigeminal neuralgia (TN) with a favorable safety profile compared with neurorestorative techniques, but its durability and recurrence patterns remain uncertain. This study evaluated the early effectiveness, durability, recurrence-free survival, and safety of peripheral PRF in refractory classical or idiopathic TN. Methods: This retrospective single-center cohort study assessed procedure-level outcomes of peripheral PRF targeting the ophthalmic, maxillary, and mandibular branches. Pain intensity and clinical status were evaluated using the Numeric Rating Scale (NRS) and Barrow Neurological Institute (BNI) pain score. Early effectiveness was defined as clinically meaningful pain relief sustained for at least 1 month, and sustained effectiveness as NRS \u2264 3 at 6 months. Recurrence-free survival was analyzed using Kaplan\u2013Meier methods. Results: A total of 68 procedures in 57 patients were analyzed. Early effectiveness at 1 month was achieved in 85.3% of procedures. Median NRS decreased from 9 (IQR 8\u20139) at baseline to 2 (0\u20134) at 1 month and 0 (0\u20132) at 3 and 6 months (p &lt; 0.001). In a worst-case analysis, 6-month sustained effectiveness was 72.1%. Recurrence occurred in 61.8% of procedures, with a median recurrence-free survival of 11 months. Among procedures with recurrence, repeat peripheral PRF was performed in 45.2%. Medication requirements decreased in 66.2% of procedures, and no major complications occurred. Conclusions: Peripheral PRF provides rapid and meaningful early pain relief in TN, but durability is limited. These findings support peripheral PRF as a safe, repeatable neuromodulatory intervention within a staged treatment strategy rather than a definitive therapy.<\/jats:p>","DOI":"10.3390\/jcm15124784","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:04:04Z","timestamp":1781874244000},"page":"4784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral Pulsed Radiofrequency for Trigeminal Neuralgia: Early Efficacy with Limited Durability in a Real-World Cohort"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-4092","authenticated-orcid":false,"given":"G\u00fcl\u00e7in","family":"Babao\u011flu","sequence":"first","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-0146","authenticated-orcid":false,"given":"Ali","family":"\u00c7o\u015ftu","sequence":"additional","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dclk\u00fc","family":"Sabuncu","sequence":"additional","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-4530","authenticated-orcid":false,"given":"\u015e\u00fckriye","family":"Dadal\u0131","sequence":"additional","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevcihan","family":"\u015eahuto\u011flu Bal","sequence":"additional","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eaziye","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan Yavuz","family":"Ak\u00e7aboy","sequence":"additional","affiliation":[{"name":"Pain Clinic, Ankara Bilkent City Hospital, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.36076\/ppj.2023.26.39","article-title":"Retrospective analysis of clinical feature in trigeminal neuralgia","volume":"26","author":"Hong","year":"2023","journal-title":"Pain Physician"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.2147\/JPR.S331036","article-title":"Trigeminal Neuralgia: Current Approaches and Emerging Interventions","volume":"14","author":"Xu","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s10194-015-0548-y","article-title":"Risk of psychiatric disorders following trigeminal neuralgia: A nationwide population-based retrospective cohort study","volume":"16","author":"Wu","year":"2015","journal-title":"J. Headache Pain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.4103\/0028-3886.315996","article-title":"Medical management of trigeminal neuralgia","volume":"69","author":"Khadilkar","year":"2021","journal-title":"Neurol. India"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/ene.13950","article-title":"European Academy of Neurology guideline on trigeminal neuralgia","volume":"26","author":"Bendtsen","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e70051","DOI":"10.1111\/papr.70051","article-title":"13. Trigeminal Neuralgia","volume":"25","author":"Snel","year":"2025","journal-title":"Pain Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.nec.2016.02.005","article-title":"Percutaneous Procedures for the Treatment of Trigeminal Neuralgia","volume":"27","author":"Wang","year":"2016","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_9","first-page":"25","article-title":"A review of percutaneous treatments for trigeminal neuralgia","volume":"10","author":"Cheng","year":"2014","journal-title":"Neurosurgery"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Okon, I.I., Menon, S.S., Osama, M., Aiman, M., Paleare, L.F.F., Eliseo, D.L., Shafqat, M.D., Ezeaku, C.O., Ferreira, M.Y., and Razouqi, Y. (2025). Microvascular decompression: A contemporary update. BMC Surg., 25.","DOI":"10.1186\/s12893-025-02762-7"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/ALN.0000000000004881","article-title":"Pain in the Context of Sensory Deafferentation","volume":"140","author":"Cohen","year":"2024","journal-title":"Anesthesiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9394(00)00796-0","article-title":"Monocular blindness as a complication of trigeminal radiofrequency rhizotomy","volume":"131","author":"Egan","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s13760-024-02638-2","article-title":"Evaluation of the efficacy of ultrasound-guided maxillary and mandibular nerve pulsed radiofrequency treatment for trigeminal neuralgia and factors associated with successful response: A retrospective study","volume":"125","author":"Can","year":"2025","journal-title":"Acta Neurol. Belg."},{"key":"ref_14","first-page":"e61565","article-title":"A Comparison Between the Efficacy of Trigeminal Ganglion Radiofrequency Thermocoagulation and Ultrasound-Guided Maxillary-Mandibular Nerve Pulsed Radiofrequency in the Treatment of Trigeminal Neuralgia: A Randomized Clinical Trial","volume":"16","author":"Yildiz","year":"2024","journal-title":"Cureus"},{"key":"ref_15","first-page":"119","article-title":"Comparison of Gasserian ganglion conventional radiofrequency ablation and peripheral nerve pulsed radiofrequency in trigeminal neuralgia: A retrospective cohort study","volume":"40","author":"Teker","year":"2026","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5480728","DOI":"10.1155\/2018\/5480728","article-title":"Ultrasound-Guided Intervention for Treatment of Trigeminal Neuralgia: An Updated Review of Anatomy and Techniques","volume":"2018","author":"Allam","year":"2018","journal-title":"Pain Res. Manag."},{"key":"ref_17","first-page":"E537","article-title":"Ultrasound-guided trigeminal nerve block via the pterygopalatine fossa: An effective treatment for trigeminal neuralgia and atypical facial pain","volume":"16","author":"Nader","year":"2013","journal-title":"Pain Physician"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lin, T.Y., Chang, K.V., Wu, W.T., Mezian, K., Ricci, V., and \u00d6z\u00e7akar, L. (2025). Ultrasound-Guided Interventions for Neuropathic Pain: A Narrative Pictorial Review. Life, 15.","DOI":"10.3390\/life15091404"},{"key":"ref_19","first-page":"467","article-title":"Pulsed Radiofrequency Treatment: Evidence for and Applications in Chronic Pain","volume":"28","author":"Jitsinthunun","year":"2025","journal-title":"Pain Physician"},{"key":"ref_20","first-page":"96","article-title":"Peripheral nerve pulsed radiofrequency for trigeminal neuralgia treatment: Is it an effective method?","volume":"35","author":"Tanyel","year":"2023","journal-title":"Agri"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0360-3016(00)00513-7","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: The initial experience of The Barrow Neurological Institute","volume":"47","author":"Rogers","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/neuros\/nyz075","article-title":"Pain Outcomes Following Microvascular Decompression for Drug-Resistant Trigeminal Neuralgia: A Systematic Review and Meta-Analysis","volume":"86","author":"Holste","year":"2020","journal-title":"Neurosurgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e884","DOI":"10.1016\/j.wneu.2019.05.022","article-title":"Adverse Events After Microvascular Decompression: A National Surgical Quality Improvement Program Analysis","volume":"128","author":"Cote","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1097\/SCS.0000000000000984","article-title":"Effectiveness and safety of microvascular decompression surgery for treatment of trigeminal neuralgia: A systematic review","volume":"25","author":"Xia","year":"2014","journal-title":"J. Craniofacial Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/pm\/pnab221","article-title":"Percutaneous Radiofrequency Rhizotomy Is Equally Effective for Trigeminal Neuralgia Patients with or Without Neurovascular Compression","volume":"23","author":"Kao","year":"2022","journal-title":"Pain Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/papr.13114","article-title":"Long-term recurrence-free survival and complications of percutaneous balloon compression and radiofrequency thermocoagulation of Gasserian ganglion for trigeminal neuralgia: A retrospective study of 1313 cases","volume":"22","author":"Zheng","year":"2022","journal-title":"Pain Pract."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lee, J.Y., Lee, G.H., Yi, S.H., Sim, W.S., Kim, B.W., and Park, H.J. (2023). Non-Surgical Treatments of Trigeminal Neuralgia from the Perspective of a Pain Physician: A Narrative Review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11082315"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1526-4637.2006.00148.x","article-title":"Pulsed radiofrequency: Current clinical and biological literature available","volume":"7","author":"Cahana","year":"2006","journal-title":"Pain Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.36076\/ppj.2024.27.E751","article-title":"Long-term Follow-up of the Effectiveness and Safety of High-voltage Pulsed Radiofrequency Treatment for Infraorbital Neuralgia: A Retrospective Study","volume":"27","author":"Sun","year":"2024","journal-title":"Pain Physician"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5812\/aapm.3493","article-title":"Pulsed radiofrequency treatment for trigeminal neuralgia","volume":"1","author":"Chua","year":"2012","journal-title":"Anesthesiol. Pain Med."},{"key":"ref_31","first-page":"E1263","article-title":"Long-term Follow-up of Pulsed Radiofrequency Treatment for Trigeminal Neuralgia: Kaplan-Meier Analysis in a Consecutive Series of 149 Patients","volume":"24","author":"Zipu","year":"2021","journal-title":"Pain Physician"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4784\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:54:15Z","timestamp":1782449655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15124784"],"URL":"https:\/\/doi.org\/10.3390\/jcm15124784","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]}}}