{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:47:18Z","timestamp":1782265638328,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital Health Development Scientific Research Project","award":["2026-1-2051"],"award-info":[{"award-number":["2026-1-2051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: We aimed to descriptively evaluate the feasibility and clinical utility of TowardPi BO (4K ultra-HD microscope integrated with a 400 kHz swept-source intraoperative optical coherence tomography (SS-iOCT) system) in managing various ophthalmic surgical conditions in a real-world setting. Methods: We analyzed surgical videos and data from 123 consecutive cases that underwent elective surgery with the assistance of this SS-iOCT system at Beijing Tongren Hospital between 2 September 2025 and 10 February 2026. Cases were included when the iOCT provided critical, real-time information that directly influenced surgical decision-making or technique modification. Cases were excluded if iOCT served only routine confirmatory or educational purposes without altering the surgical plan. Results: A total of 72 surgical cases were included, comprising 7 intraocular lens implantations with ciliary sulcus fixation, 19 macular holes, 3 cases of macular hole retinal detachment (MHRD), 4 cases of macular schisis with or without foveal detachment (MSRD), 12 cases of submacular hemorrhage, 20 cases of rhegmatogenous retinal detachment (RRD), and 7 intraocular mass lesions. The 400 kHz SS-iOCT significantly aided in surgical visualization, guided real-time decision-making, and prompted modifications in surgical techniques. Conclusions: To our knowledge, this is the first real-world study to evaluate the application of a 400 kHz SS-iOCT system across a wide spectrum of ophthalmic conditions, including its novel use in intraocular tumors. From routine to complex surgical cases, SS-iOCT enhances surgical precision and facilitates real-time decision-making, ultimately contributing to improved surgical outcomes.<\/jats:p>","DOI":"10.3390\/jcm15124791","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:03:23Z","timestamp":1782263003000},"page":"4791","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-World Application of Microscope-Integrated 400 kHz Swept-Source Intraoperative OCT in Ophthalmic Surgery"],"prefix":"10.3390","volume":"15","author":[{"given":"Xifang","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Luhe Hospital, Capital Medical University, Beijing 101199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengteng","family":"Yao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7857-5482","authenticated-orcid":false,"given":"Yuheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Alley, Dongcheng District, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1364\/OL.35.003315","article-title":"Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery","volume":"35","author":"Tao","year":"2010","journal-title":"Opt. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1364\/BOE.488967","article-title":"Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography","volume":"14","author":"Li","year":"2023","journal-title":"Biomed. Opt. Express."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3928\/23258160-20180129-03","article-title":"Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging","volume":"49","author":"Lu","year":"2018","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4103\/tjo.TJO-D-24-00078","article-title":"Advances in intraoperative imaging in retinal diseases: A narrative review","volume":"14","author":"Rocha","year":"2024","journal-title":"Taiwan J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"di Geronimo, N., Moramarco, A., Romano, V., Mete, M., and Fontana, L. (2025). Overcoming Opacity: The Role of Intraoperative OCT in Complex Corneal and Anterior Segment Surgery. Bioengineering, 13.","DOI":"10.3390\/bioengineering13010015"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.oret.2019.11.002","article-title":"Intraoperative OCT-Assisted Retinal Detachment Repair in the DISCOVER Study: Impact and Outcomes","volume":"4","author":"Abraham","year":"2020","journal-title":"Ophthalmol. Retin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.oret.2018.02.013","article-title":"Intraoperative OCT for Uveitis-Related Vitreoretinal Surgery in the DISCOVER Study","volume":"2","author":"Kumar","year":"2018","journal-title":"Ophthalmol. Retin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e153530","DOI":"10.5812\/healthscope-153530","article-title":"Intra-Operative Ocular Coherence Tomography in Retinal Detachment Surgery","volume":"14","author":"Zakir","year":"2024","journal-title":"Health Scope"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.oret.2017.05.006","article-title":"Outcomes of Intraoperative OCT-Assisted Epiretinal Membrane Surgery from the PIONEER Study","volume":"2","author":"Ehlers","year":"2018","journal-title":"Ophthalmol. Retin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.oret.2021.02.013","article-title":"Epiretinal Membrane Surgery Using Intraoperative OCT-Guided Membrane Removal in the DISCOVER Study versus Conventional Membrane Removal","volume":"5","author":"Tuifua","year":"2021","journal-title":"Ophthalmol. Retin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102302","DOI":"10.1016\/j.ajoc.2025.102302","article-title":"Human amniotic membrane graft with viscodissection and intraoperative OCT for macular hole repair","volume":"38","author":"Qian","year":"2025","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3928\/23258160-20210913-01","article-title":"Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes","volume":"52","author":"Huang","year":"2021","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00417-020-05047-2","article-title":"Intraoperative optical coherence tomography-assisted displacement of prepapillary membrane in eyes with optic disc pit maculopathy","volume":"259","author":"Inoue","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Parolini, B., Ripa, M., Frisina, R., Matello, V., and Motta, L. (2023). The Role of the Intraoperative Optical Coherence Tomography for Vitreoretinal Surgery in a Real-Life Setting. Life, 13.","DOI":"10.3390\/life13091813"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1097\/j.jcrs.0000000000000615","article-title":"Adjustment of intraocular lens tilt during intrascleral fixation assisted by intraoperative OCT","volume":"47","author":"Fukumoto","year":"2021","journal-title":"J. Catarac. Refract. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1177\/11206721241306777","article-title":"Intraoperative OCT evaluation of the stability and centering of carlevale IOL with different intrascleral fixation techniques","volume":"35","author":"Brancato","year":"2025","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1364\/BOE.483278","article-title":"Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography","volume":"14","author":"Li","year":"2023","journal-title":"Biomed. Opt. Express"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40942-024-00564-2","article-title":"Effect of internal limiting membrane surgical techniques on the idiopathic and refractory management of macular holes: A systematic review and meta-analysis","volume":"10","year":"2024","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.oret.2025.02.003","article-title":"ILM Flap Study Group. Internal Limiting Membrane Flaps in Macular Hole Surgery: A Systematic Review and Individual Participant Data Meta-analysis","volume":"9","author":"Tzoumas","year":"2025","journal-title":"Ophthalmol. Retin."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12187","DOI":"10.1038\/s41598-025-95561-2","article-title":"Analysis of clinical features and SS-OCT findings in patients with focal choroidal excavation","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/tomography9050132","article-title":"The State of Intraoperative OCT in Vitreoretinal Surgery: Recent Advances and Future Challenges","volume":"9","author":"Ciarmatori","year":"2023","journal-title":"Tomography"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ong, J., Zarnegar, A., Corradetti, G., Singh, S.R., and Chhablani, J. (2022). Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175139"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/tvst.5.3.4","article-title":"Histopathologic Findings in the Areas of Orange Pigment Overlying Choroidal Melanomas","volume":"5","author":"Garcia","year":"2016","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2023.05.009","article-title":"Tumor-associated retinal pigmentation (TARP) in choroidal melanoma","volume":"130","author":"Wallace","year":"2023","journal-title":"Ophthalmology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.21516\/2072-0076-2022-15-2-99-108","article-title":"Comparison of signs of choroidal melanoma spreading into the retina according to optical coherenct tomography and pathomorphological studies","volume":"15","author":"Stoyukhina","year":"2022","journal-title":"Russ. Ophthalmol. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000510575","article-title":"Multifocal Intraretinal Tumour Deposits following Treatment of an Ipsilateral Choroidal Melanoma","volume":"6","author":"Jamison","year":"2020","journal-title":"Ocul. Oncol. Pathol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4791\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:24:51Z","timestamp":1782264291000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/12\/4791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15124791"],"URL":"https:\/\/doi.org\/10.3390\/jcm15124791","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]}}}