{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:46:15Z","timestamp":1782539175128,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: degenerative cervical myelopathy (DCM) is the leading cause of spinal cord impairment in adults, often resulting in disability and reduced quality of life (QoL). Surgery is recommended for moderate and severe cases, while its role in mild DCM remains debated. Emerging evidence suggests that early surgery may improve outcomes, particularly QoL. Methods: We conducted a retrospective, single-center observational study of a cohort of patients undergoing cervical spine surgery for DCM between January 2020 and August 2023 at a single institution (Policlinico di Monza, Italy). Demographic, clinical, radiological and surgical data, as well as complications and outcomes, were analyzed. Neurological status was assessed using the modified Japanese Orthopedic Association (mJOA) score and QoL was evaluated using the Short Form-36 (SF-36) questionnaire preoperatively, at discharge, and at follow-up. Results: 51 patients were included (mean age 58.1 years; 41% female), with anterior surgery performed in 67%. Mild preoperative mJOA score was observed in 74% of patients. At follow-up, 65% achieved complete recovery, 29% improved, and 6% remained stable. No neurological deterioration was recorded. Univariate analysis identified age, anterior cervical discectomy and fusion (ACDF), and mild preoperative mJOA score as significant predictors of recovery. Multivariate logistic regression analysis identified mild preoperative mJOA score as a strong independent predictor of complete clinical recovery (OR = 240.64, 95% CI: 6.82\u20138496.22, p = 0.002). SF-36 showed significant improvements in emotional well-being, social functioning, pain, and general health, particularly in mild cases. Complications were low (5.8%) and limited to transient dysphagia. Conclusions: early surgical treatment in selected patients with mild DCM may be associated with favorable neurological and quality-of-life outcomes, although larger prospective studies are needed.<\/jats:p>","DOI":"10.3390\/jcm15124844","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:09:17Z","timestamp":1782270557000},"page":"4844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Early Surgical Treatment in Degenerative Cervical Myelopathy Have a Favorable Clinical Outcome and Impact on Quality of Life?"],"prefix":"10.3390","volume":"15","author":[{"given":"Michele","family":"Incerti","sequence":"first","affiliation":[{"name":"Unit of Neurosurgery, Policlinico di Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-7867","authenticated-orcid":false,"given":"Paola M. F.","family":"Cristaldi","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Policlinico di Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Parlangeli","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Policlinico di Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Ricciuti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, School of Medicine, University of Milano-Bicocca, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Balletti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, School of Medicine, University of Milano-Bicocca, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Policlinico di Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Cavadoli","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Policlinico di Monza, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-3464","authenticated-orcid":false,"given":"Franco","family":"Servadei","sequence":"additional","affiliation":[{"name":"Global Neurosurgery Programme, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E675","DOI":"10.1097\/BRS.0000000000000913","article-title":"Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis","volume":"40","author":"Nouri","year":"2015","journal-title":"Spine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/2192568220934496","article-title":"The Prevalence of Asymptomatic and Symptomatic Spinal Cord Compression on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis","volume":"11","author":"Smith","year":"2021","journal-title":"Glob. 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