{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:30:38Z","timestamp":1786617038925,"version":"build-2736575974"},"reference-count":26,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB06\/06\/1088"],"award-info":[{"award-number":["CB06\/06\/1088"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC21_2\/00039"],"award-info":[{"award-number":["AC21_2\/00039"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"award":["CB06\/06\/1088"],"award-info":[{"award-number":["CB06\/06\/1088"]}],"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AC21_2\/00039"],"award-info":[{"award-number":["AC21_2\/00039"]}],"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"publisher"}]},{"name":"ERAPerMed","award":["JTC_2021"],"award-info":[{"award-number":["JTC_2021"]}]},{"name":"European Regional Development Funds, Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias","award":["PIFIISC24\/22"],"award-info":[{"award-number":["PIFIISC24\/22"]}]},{"name":"Asociaci\u00f3n Cient\u00edfica Pulm\u00f3n y Ventilaci\u00f3n Mec\u00e1nica"},{"name":"Core Grant","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]},{"name":"Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center"},{"id":[{"id":"https:\/\/ror.org\/02yrq0923","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Ventilation is an essential function of life, and one of the first to be replicated by artificial means. Annually, it is estimated that 15 to 20 million patients worldwide are intubated and receive invasive mechanical ventilation (MV). However, MV is a non-physiologic intervention and frequent complications are associated with its use, including extravascular lung liquid, impaired cardiac performance, and alveolar rupture. Research shows that injurious MV can cause or aggravate lung damage and initiate an intense inflammatory response, contributing to multiple organ dysfunction and poor outcomes due to ventilator-induced lung liquid and intense alveolar rupture. In this brief commentary, we postulate that this resulting injury is better characterized with the term \u201cventilator-induced lung liquid and alveolar rupture\u201d. We will summarize key points for clinical implications, existing challenges, and future perspectives for the management of patients with severe acute hypoxemic respiratory failure.<\/jats:p>","DOI":"10.3390\/jcm15134884","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:09:17Z","timestamp":1782270557000},"page":"4884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ventilator-Induced Lung Liquid and Alveolar Rupture"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5687-3562","authenticated-orcid":false,"given":"Jes\u00fas","family":"Villar","sequence":"first","affiliation":[{"name":"CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Research Unit at Hospital Dr. Negr\u00edn, Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias, 35019 Las Palmas de Gran Canaria, Spain"},{"name":"Li Ka Shing Knowledge Institute, Sta Michael Hospital, Toronto, ON M5B 1W8, Canada"},{"name":"Faculty of Health Sciences, Universidad del Atl\u00e1ntico Medio, Tafira Baja, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-7062","authenticated-orcid":false,"given":"Stephen M.","family":"Pastores","sequence":"additional","affiliation":[{"name":"Critical Care Center, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA"},{"name":"Medicine in Clinical Anesthesiology and Medicine, Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajic.2025.09.008","article-title":"Impact of ventilator-associated events on clinical outcomes in mechanically ventilated patients: A retrospective cohort study from a Brazilian ICU","volume":"54","author":"Pereira","year":"2026","journal-title":"Am. 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