{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:52:37Z","timestamp":1782395557927,"version":"3.54.5"},"reference-count":34,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: To evaluate whether gabapentin pretreatment modulates neuronal excitability and attenuates second-eye hyperalgesia in patients undergoing sequential bilateral cataract surgery under monitored anesthesia care with retrobulbar block. Methods: We conducted a prospective, parallel-group, randomized controlled trial with blinded outcome assessors at a tertiary university hospital. Patients aged &gt; 60 years undergoing elective sequential bilateral cataract surgeries with a 1-week interval were enrolled. Participants were randomized 1:1 to receive gabapentin (100 mg three times daily for 1 week between surgeries) or no pretreatment. The primary outcome was the incidence of hyperalgesia, defined as greater intraoperative pain during the second-eye surgery compared to the first. Secondary outcomes included preoperative anxiety level, intraoperative and postoperative pain score, opioid rescue requirements, and surgeon\/patient satisfaction for first- and second-eye surgeries. Results: Sixty-four patients (128 eyes) were included and analyzed (31 per group). Hyperalgesia was lower in the gabapentin pretreatment group than in the control group (4 [12.9%] vs. 17 [54.8%], risk ratio 0.24, 95% confidence interval 0.09\u20130.63, p = 0.001). Maximum intraoperative pain significantly decreased from the first to the second surgery in the gabapentin pretreatment group, whereas it increased in the control group (mean difference [standard deviation], \u22121.48 [2.14] vs. 0.97 [1.96], p &lt; 0.001). Preoperative anxiety improved similarly in both groups before the second surgery. Conclusions: Gabapentin pretreatment may represent a promising strategy for reducing second-eye hyperalgesia and improving perioperative pain-related outcomes in older patients undergoing sequential bilateral cataract surgery under monitored anesthesia care with retrobulbar block.<\/jats:p>","DOI":"10.3390\/jcm15134944","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:37:55Z","timestamp":1782391075000},"page":"4944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract Surgery: A Prospective, Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-0177","authenticated-orcid":false,"given":"Seihee","family":"Min","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-618X","authenticated-orcid":false,"given":"Jiwon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong 14353, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-5314","authenticated-orcid":false,"given":"Joo Youn","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-2727","authenticated-orcid":false,"given":"Jeong-Hwa","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1167\/iovs.16-19894","article-title":"Cataract Surgical Rate and Socioeconomics: A Global Study","volume":"57","author":"Wang","year":"2016","journal-title":"Investig. 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