{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:15:20Z","timestamp":1783142120646,"version":"3.54.6"},"reference-count":79,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Apical pelvic organ prolapse (POP) is characterized by descent of the uterus or post-hysterectomy vaginal vault resulting from failure of level I pelvic support and represents a major contributor to pelvic floor dysfunction and recurrent prolapse surgery. Loss of apical support is frequently associated with anterior and posterior compartment defects, leading to vaginal bulge symptoms, pelvic pressure, urinary and bowel dysfunction, sexual dysfunction, and reduced quality of life. This narrative review summarizes current knowledge on POP, from molecular mechanisms and emerging biomarkers to contemporary surgical management, with particular emphasis on sacrocolpopexy and robotic-assisted approaches. A literature search of PubMed, Scopus, Google Scholar, and Consensus identified peer-reviewed studies published up to February 2026. Evidence demonstrates that POP has a multifactorial and polygenic background involving extracellular matrix remodeling, connective tissue integrity, smooth muscle dysfunction, and altered level of protein expression. Several candidate biomarkers, including single-nucleotide polymorphisms, circulating proteins, metabolites, and imaging-based parameters, show potential for risk prediction and earlier diagnosis, although routine clinical implementation remains limited. Sacrocolpopexy remains the gold standard for apical prolapse repair because of superior anatomical outcomes, low recurrence, and significant quality-of-life improvement. Laparoscopic and robotic-assisted sacrocolpopexy provide comparable efficacy with reduced blood loss, shorter hospitalization, and faster recovery. The objective success rate is usually over 90%. Complications are very rare and typically include mesh erosion in 2\u20134% of cases and the need for reoperation in 6% of cases. Our own experience shows that, for a group of surgeons, the learning curve for the laparoscopic approach reached a plateau after a total of 30 operations. Robotic platforms may facilitate complex pelvic dissection and shorten the learning curve, although higher procedural costs remain a major limitation.<\/jats:p>","DOI":"10.3390\/jcm15134967","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:49:23Z","timestamp":1782434963000},"page":"4967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pelvic Organ Prolapse with an Emphasis on the Central Compartment: From Genetic Risk Factors and Biomarkers to Contemporary Sacropexy and Emerging Robotic Innovations"],"prefix":"10.3390","volume":"15","author":[{"given":"Micha\u0142","family":"Pomorski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Center of Obstetrics and Gynecology, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-261X","authenticated-orcid":false,"given":"Tomasz","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Center of Obstetrics and Gynecology, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kryza-Ottou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Center of Obstetrics and Gynecology, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Budny-Wi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Center of Obstetrics and Gynecology, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"\u015aliwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Center of Obstetrics and Gynecology, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-3421","authenticated-orcid":false,"given":"Adam","family":"Pomorski","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology, Faculty of Biotechnology, University of Wroc\u0142aw, 50-383 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0002-9378(12)91840-2","article-title":"Structural support of the urethra as it relates to stress urinary incontinence: The hammock hypothesis","volume":"170","author":"DeLancey","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/AOG.0b013e3181f73729","article-title":"Lifetime risk of undergoing surgery for pelvic organ prolapse","volume":"116","author":"Smith","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0029-7844(97)00058-6","article-title":"Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence","volume":"89","author":"Olsen","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/AOG.0000000000000286","article-title":"Lifetime Risk of Stress Urinary Incontinence or Pelvic Organ Prolapse Surgery","volume":"123","author":"Wu","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/0002-9378(92)91562-O","article-title":"Anatomic aspects of vaginal eversion after hysterectomy","volume":"166","author":"DeLancey","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s00192-022-05081-0","article-title":"International Urogynecological Consultation (IUC): Pathophysiology of pelvic organ prolapse (POP)","volume":"33","author":"Deprest","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00192-008-0718-4","article-title":"Incidence rate and risk factors for vaginal vault prolapse repair after hysterectomy","volume":"19","author":"Jacob","year":"2008","journal-title":"Int. Urogynecol. J."},{"key":"ref_8","unstructured":"(2026, June 02). True Incidence of Vaginal Vault Prolapse. Thirteen Years of Experience\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/10483537\/."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","article-title":"An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction","volume":"21","author":"Haylen","year":"2010","journal-title":"Int. Urogynecol. J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"(2019). Pelvic Organ Prolapse: ACOG Practice Bulletin, Number 214. Obstet. Gynecol., 134, E126\u2013E142.","DOI":"10.1097\/AOG.0000000000003519"},{"key":"ref_11","unstructured":"(2026, March 29). Overview|Urinary Incontinence and Pelvic Organ Prolapse in Women: Management|Guidance|NICE. Available online: https:\/\/www.nice.org.uk\/guidance\/ng123."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00006250-196207000-00009","article-title":"Repair of posthysterectomy vaginal-vault prolapse","volume":"20","author":"Lane","year":"1962","journal-title":"Obstet. Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00192-014-2369-y","article-title":"Schaer Long-term follow-up of laparoscopic sacrocolpopexy","volume":"25","author":"Sarlos","year":"2014","journal-title":"Int. Urogynecol. J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jamaleddine, H.M., Khalil, N., Aoun, R., and Atallah, D. (2025). Robotic sacrocolpopexy: A game worth playing? A critical literature analysis. Front. Surg., 12.","DOI":"10.3389\/fsurg.2025.1561976"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Das, S., Dey, M.K., Devireddy, R., and Gartia, M.R. (2024). Biomarkers in Cancer Detection, Diagnosis, Prognosis. Sensors, 24.","DOI":"10.3390\/s24010037"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s00192-005-0054-x","article-title":"Familial transmission of genitovaginal prolapse","volume":"17","author":"Jack","year":"2006","journal-title":"Int. Urogynecol. J. Pelvic Floor Dysfunct."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00192-020-04559-z","article-title":"Family history and pelvic organ prolapse: A systematic review and meta-analysis","volume":"32","author":"Samimi","year":"2021","journal-title":"Int. Urogynecol. J."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jiang, W., Cheung, R.Y.K., Chung, C.Y., Chan, S.S.C., and Choy, K.W. (2024). Genetic Etiology in Pelvic Organ Prolapse: Role of Connective Tissue Homeostasis, Hormone Metabolism, Oxidative Stress. Genes, 16.","DOI":"10.3390\/genes16010005"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/GME.0000000000001448","article-title":"Genetic polymorphisms in collagen-related genes are associated with pelvic organ prolapse","volume":"27","author":"Li","year":"2020","journal-title":"Menopause"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00192-021-04917-5","article-title":"The polymorphisms of extracellular matrix-remodeling genes are associated with pelvic organ prolapse","volume":"33","author":"Li","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/AOG.0b013e318262234b","article-title":"Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse","volume":"120","author":"Wu","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.maturitas.2014.05.003","article-title":"Fibulin-5 (FBLN5) gene polymorphism is associated with pelvic organ prolapse","volume":"78","author":"Khadzhieva","year":"2014","journal-title":"Maturitas"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00192-025-06048-7","article-title":"Whole Exome Sequencing Reveals Candidate Variants in Ion Channel Genes for Pelvic Muscle Dysfunction in Young Females with a Family History","volume":"36","author":"Szymanowski","year":"2025","journal-title":"Int. Urogynecol. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"311.e1","DOI":"10.1016\/j.ajog.2025.03.029","article-title":"Inherited and de novo variants in young females potentially associated with pelvic organ prolapse","volume":"233","author":"Szymanowski","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.ajog.2025.06.001","article-title":"Genetics of female pelvic organ prolapse","volume":"233","author":"Li","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: The Universal Protein Knowledgebase in 2025","volume":"53","author":"Bateman","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.4103\/0366-6999.170262","article-title":"Proteomic analysis of the uterosacral ligament in postmenopausal women with and without pelvic organ prolapse","volume":"128","author":"Sun","year":"2015","journal-title":"Chin. Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1800086","DOI":"10.1002\/prca.201800086","article-title":"Proteomics of Uterosacral Ligament Connective Tissue from Women with and without Pelvic Organ Prolapse","volume":"13","author":"Li","year":"2019","journal-title":"Proteom. Clin. Appl."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jchromb.2008.01.027","article-title":"Quantitative analysis of 17 amino acids in the connective tissue of patients with pelvic organ prolapse using capillary electrophoresis\u2013tandem mass spectrometry","volume":"865","author":"Shama","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.21037\/atm-21-1607","article-title":"Proteins in plasma as a potential biomarkers diagnostic for pelvic organ prolapse","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121882","DOI":"10.1016\/j.jchromb.2019.121882","article-title":"Metabolomics study of serum and urine samples reveals metabolic pathways and biomarkers associated with pelvic organ prolapse","volume":"1136","author":"Deng","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s42003-020-0857-9","article-title":"Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank","volume":"3","author":"Olafsdottir","year":"2020","journal-title":"Commun. Biol."},{"key":"ref_33","first-page":"3584","article-title":"Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse","volume":"3","author":"Lepamets","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00192-025-06338-0","article-title":"3D MRI Biomarkers for Predicting Pelvic Organ Prolapse Risk and Severity","volume":"37","author":"Bai","year":"2026","journal-title":"Int. Urogynecol. J."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"De Vicari, D., Barba, M., Cola, A., Costa, C., Palucci, M., and Frigerio, M. (2025). AI-Enhanced 3D Transperineal Ultrasound: Advancing Biometric Measurements for Precise Prolapse Severity Assessment. Bioengineering, 12.","DOI":"10.3390\/bioengineering12070754"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"755.e1","DOI":"10.1016\/j.ajog.2015.02.017","article-title":"Prolapse and continence surgery in countries of the Organization for Economic Cooperation and Development in 2012","volume":"212","author":"Haya","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4111\/icu.2019.60.6.413","article-title":"Current surgical management of pelvic organ prolapse: Strategies for the improvement of surgical outcomes","volume":"60","author":"Ko","year":"2019","journal-title":"Investig. Clin. Urol."},{"key":"ref_38","unstructured":"Cardozo, L., Rovner, E., Wagg, A., Wein, A., Abrams, P., Maher, C., Antosh, D., Baessler, K., Cheon, C., and de Tayrac, R. (2026, March 30). ICS|Incontinence 7th Edition. 2023, ch. POP Surgery. Available online: https:\/\/www.ics.org\/ici\/."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1159\/000324243","article-title":"Managing Mesh Erosion after Abdominal Pelvic Organ Prolapse Repair: Ten Years\u2019 Experience in a Single Center","volume":"86","author":"Costantini","year":"2011","journal-title":"Urol. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1038\/s41598-020-61995-z","article-title":"Long-term follow-up of 453 patients with pelvic organ prolapse who underwent transvaginal sacrospinous colpopexy with Veronikis ligature carrier","volume":"10","author":"Wu","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/IJWH.S54845","article-title":"Clinical challenges in the management of vaginal prolapse","volume":"6","author":"Siddiqui","year":"2014","journal-title":"Int. J. Womens Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00404-023-07140-3","article-title":"Quality-of-life improvements in patients after various surgical treatments for pelvic organ prolapse","volume":"309","author":"Guan","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/AOG.0000000000003380","article-title":"Long-Term Assessment of a Prospective Cohort of Patients Undergoing Laparoscopic Sacrocolpopexy","volume":"134","author":"Nawapun","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00192-021-04823-w","article-title":"Comparison of the effectiveness of sacrospinous ligament fixation and sacrocolpopexy: A meta-analysis","volume":"33","author":"Zhang","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/SPV.0000000000001396","article-title":"European Urogynaecological Association Position Statement: Pelvic Organ Prolapse Surgery","volume":"29","author":"Padoa","year":"2023","journal-title":"Urogynecology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"114559","DOI":"10.1016\/j.ejogrb.2025.114559","article-title":"Evidence-based recommendations of the International Society for Gynecologic Endoscopy (ISGE) for the prevention of apical prolapse following vaginal hysterectomy for prolapsed and non-prolapsed uterus","volume":"312","author":"Chrysostomou","year":"2025","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Dubuisson, J.-B., Dubuisson, J., Favre, M.M., and Wirth, G.J. (2022). Ureteral Complications of Gynecological Surgery, Springer International Publishing.","DOI":"10.1007\/978-3-031-15598-7"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/01.AOG.0000139514.90897.07","article-title":"Abdominal sacrocolpopexy: A comprehensive review","volume":"104","author":"Nygaard","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"457.e1","DOI":"10.1016\/j.ajog.2017.12.236","article-title":"The anatomy of the sacral promontory: How to avoid complications of the sacrocolpopexy procedure","volume":"218","author":"Giraudet","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Malanowska-Jarema, E., Starczewski, A., Melnyk, M., Oliveira, D., Balzarro, M., and Randomized, E.R.A. (2024). Clinical Trial Comparing Dubuisson Laparoscopic Lateral Suspension with Laparoscopic Sacropexy for Pelvic Organ Prolapse: Short-Term Results. J. Clin. Med., 13.","DOI":"10.3390\/jcm13051348"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00192-011-1539-4","article-title":"Risks, symptoms, management of pelvic nerve damage secondary to surgery for pelvic organ prolapse: A report of 95 cases","volume":"22","author":"Possover","year":"2011","journal-title":"Int. Urogynecol. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/aogs.13337","article-title":"Functional outcome after laparoscopic nerve-sparing sacrocolpopexy: A prospective cohort study","volume":"97","author":"Koerting","year":"2018","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ejogrb.2021.07.044","article-title":"Laparoscopic lateral suspension for pelvic organ prolapse: A systematic literature review","volume":"264","author":"Campagna","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_54","unstructured":"(2026, May 27). Pelvic Organ Prolapse (POP): Surgical Mesh Considerations and Recommendations|FDA, Available online: https:\/\/www.fda.gov\/medical-devices\/urogynecologic-surgical-mesh-implants\/pelvic-organ-prolapse-pop-surgical-mesh-considerations-and-recommendations."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.urology.2020.05.009","article-title":"Inaccuracies in News Media Reporting About the 2019 US Food and Drug Administration Ban on Transvaginal Mesh for Pelvic Organ Prolapse Repair","volume":"150","author":"Ray","year":"2021","journal-title":"Urology"},{"key":"ref_56","first-page":"115","article-title":"Laparoscopic Sacrocolpopexy, Hysterectomy, Burch Colposuspension: Feasibility and Short-Term Complications of 77 Procedures","volume":"6","author":"Cosson","year":"2002","journal-title":"JSLS"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/ases.12478","article-title":"Laparoscopic versus abdominal sacrocolpopexy for treatment of multi-compartmental pelvic organ prolapse: A systematic review","volume":"11","author":"Ichikawa","year":"2018","journal-title":"Asian J. Endosc. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00192-019-03952-7","article-title":"Mesh-related complications of laparoscopic sacrocolpopexy","volume":"30","author":"Baines","year":"2019","journal-title":"Int. Urogynecol. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00192-021-04865-0","article-title":"Laparoscopic sacral hysteropexy versus laparoscopic sacral colpopexy plus supracervical hysterectomy in patients with pelvic organ prolapse","volume":"33","author":"Campagna","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s00192-023-05534-0","article-title":"Comparison of outcomes of laparoscopic sacrocolpopexy with concomitant supracervical hysterectomy or uterine preservation","volume":"34","author":"Sato","year":"2023","journal-title":"Int. Urogynecol. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108755","DOI":"10.1016\/j.maturitas.2025.108755","article-title":"The uterus debate in vaginal native tissue repair for pelvic organ prolapse: Hysteropexy versus hysterectomy\u2013A systematic review and meta-analysis","volume":"203","author":"Ruffolo","year":"2025","journal-title":"Maturitas"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"461.e1","DOI":"10.1016\/j.ajog.2024.10.021","article-title":"Hysterectomy versus uterine preservation for pelvic organ prolapse surgery: A prospective cohort study","volume":"232","author":"Brennand","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4253\/wjge.v9.i5.211","article-title":"Nerve preserving vs standard laparoscopic sacropexy: Postoperative bowel function","volume":"9","author":"Cosma","year":"2017","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s00192-024-05922-0","article-title":"Sacrocolpopexy: The Way I Do It","volume":"35","author":"Shahid","year":"2024","journal-title":"Int. Urogynecol. J."},{"key":"ref_65","first-page":"62958","article-title":"Role of Robotic-Assisted Surgery in Public Health: Its Advantages and Challenges","volume":"16","author":"Handa","year":"2024","journal-title":"Cureus"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1007\/s00464-023-10275-8","article-title":"Laparoscopic versus robotic abdominal and pelvic surgery: A systematic review of randomised controlled trials","volume":"37","author":"Kawka","year":"2023","journal-title":"Surg. Endosc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.52054\/FVVO.16.4.047","article-title":"Comparison between learning curves of robot-assisted and laparoscopic surgery in gynaecology: A systematic review","volume":"16","author":"Raimondo","year":"2024","journal-title":"Facts Views Vis. Obgyn"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Capozzi, V.A., Scarpelli, E., Armano, G., Monfardini, L., Celardo, A., Munno, G.M., Fortunato, N., Vagnetti, P., Schettino, M.T., and Grassini, G. (2022). Update of Robotic Surgery in Benign Gynecological Pathology: Systematic Review. Medicina, 58.","DOI":"10.3390\/medicina58040552"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11701-020-01177-1","article-title":"Evaluating the morbidity and long-term efficacy of laparoscopic sacrocolpopexy with and without robotic assistance for pelvic organ prolapse","volume":"15","author":"Lallemant","year":"2020","journal-title":"J. Robot. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10397-016-0930-z","article-title":"Laparoscopic versus robotic-assisted sacrocolpopexy for pelvic organ prolapse: A systematic review","volume":"13","author":"Callewaert","year":"2016","journal-title":"Gynecol. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"S871","DOI":"10.1016\/j.ajog.2022.12.124","article-title":"Cost comparison of laparoscopic and robotic assisted sacrocolpopexy","volume":"228","author":"Sears","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00192-022-05391-3","article-title":"Surgical cost of robotic-assisted sacrocolpopexy: A comparison of two robotic platforms","volume":"34","author":"Clark","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Strauss, M., Kennes, L.N., Dombrowski, J., Stickeler, E., Gr\u00e4f, C., Lube, K., Hillmeyer, A., and Najjari, L. (2025). Laparoscopic vs. robotic sacrocolpopexy: Influence of age, BMI, parity on perioperative outcomes. Front. Surg., 12.","DOI":"10.3389\/fsurg.2025.1625404"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1007\/s00192-024-05942-w","article-title":"Outcomes of Laparoscopic versus Robotic-Assisted Sacrocolpopexy for Pelvic Organ Prolapse\u2013A Comprehensive Retrospective Analysis","volume":"35","author":"Dehan","year":"2024","journal-title":"Int. Urogynecol. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"358.e1","DOI":"10.1016\/j.ajog.2019.09.048","article-title":"Robotic laparoendoscopic single-site compared with robotic multi-port sacrocolpopexy for apical compartment prolapse","volume":"222","author":"Matanes","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0094-0143(01)80017-3","article-title":"Promontofixation for the treatment of prolapse","volume":"28","author":"Wattiez","year":"2001","journal-title":"Urol. Clin. N. Am."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.eururo.2013.12.064","article-title":"A Review of the Current Status of Laparoscopic and Robot-assisted Sacrocolpopexy for Pelvic Organ Prolapse","volume":"65","author":"Lee","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"509","DOI":"10.5468\/ogs.23073","article-title":"Outcomes of robotic sacrocolpopexy","volume":"66","author":"Oh","year":"2023","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00192-014-2412-z","article-title":"Analysis of the learning process for laparoscopic sacrocolpopexy: Identification of challenging steps","volume":"25","author":"Claerhout","year":"2014","journal-title":"Int. Urogynecol. J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/13\/4967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:17:58Z","timestamp":1783138678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/13\/4967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":79,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15134967"],"URL":"https:\/\/doi.org\/10.3390\/jcm15134967","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}