{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:43:57Z","timestamp":1782729837225,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Carotid body tumour (CBT) resection carries substantial haemorrhage and cranial neuropathy risks. While preoperative embolisation mitigates these, its impact on patient-reported outcomes (PROMs) and quality of life (QoL) remains underexplored. Evaluate the preoperative embolisation\u2019s impact on postoperative QoL using the 36-Item Short Form Health Survey (SF-36) questionnaire. Methods: A retrospective cohort study (68 patients) compared Preoperative Embolisation (Group E, n = 24) and Primary Resection (Group NE, n = 44), adjusting for confounders via multivariate linear regression. Results: Group E featured larger, more complex tumours. Despite this structural burden, intraoperative bleeding was significantly lower in Group E (median 300, Interquartile Range (IQR) 150\u2013400 vs. 400 mL, IQR 350\u2013500; p = 0.012). Group E reported lower overall median SF-36 scores (59.5 vs. 70 points; p = 0.002); however, multivariate analysis confirmed that embolisation was not an independent negative QoL predictor (b = \u22120.52, p = 0.852), whereas Shamblin grade III was associated with diminished well-being (b = \u22127.42, p = 0.012). Domain analysis revealed selective restrictions driven by acute somatic and emotional stress: Physical Functioning (p = 0.002), Bodily Pain (p = 0.007), General Health (p = 0.003), Vitality (p = 0.016), and Role Emotional (p = 0.010). Age stratification revealed a non-linear trend, validated via ANOVA (p = 0.013): working-age patients (&lt;60 years) exhibited significantly lower SF-36 scores (61.2 \u00b1 11.4 points) than the intermediate (p = 0.034) and elderly (p = 0.011) subgroups (&gt;70 years; 72.8 \u00b1 5.1 points). Conclusions: Preoperative embolisation optimises hemodynamic control and surgical safety without independently compromising long-term well-being. Postoperative QoL is heavily modulated by age-dependent generational psychosocial baselines rather than structural morbidity metrics alone.<\/jats:p>","DOI":"10.3390\/jcm15134990","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:45:20Z","timestamp":1782722720000},"page":"4990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Safety and Preservation of Quality of Life in Carotid Body Tumour Resection: The Role of Embolisation and Vulnerability Analysis in Working-Age Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6989-2522","authenticated-orcid":false,"given":"Delfino","family":"P\u00e9rez-Ugarte","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Hospital Regional Lic. Adolfo L\u00f3pez Mateos, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City CP 01030, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Lozano-Corona","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Hospital Regional Lic. Adolfo L\u00f3pez Mateos, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City CP 01030, Mexico"},{"name":"Faculty of Medicine, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City CP 04500, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Nicol\u00e1s","family":"Hidalgo-Delgado","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Hospital Regional Lic. Adolfo L\u00f3pez Mateos, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City CP 01030, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3645-4373","authenticated-orcid":false,"given":"R\u00e9gulo","family":"L\u00f3pez-Callejas","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaciones Nucleares, Mexico City CP 52750, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/bjr\/tqaf096","article-title":"CT angiography of the carotid body: Bridging the gap between normal and neoplastic lesions","volume":"98","author":"Uzun","year":"2025","journal-title":"Br. J. 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