{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:44:02Z","timestamp":1782729842577,"version":"3.54.5"},"reference-count":18,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The impact of long-term residence in uranium legacy-affected areas on surgical outcomes in patients with lower extremity artery disease (LEAD) remains insufficiently studied. Objectives: This study aimed to compare early postoperative dynamics of chronic lower limb ischemia (CLLI) in patients with LEAD residing in uranium legacy-affected areas and those living outside the zone of potential technogenic exposure. Methods: The study included 70 patients with LEAD (CLLI stages IIB\u2013IV according to the Fontaine classification). The study group (n = 35) consisted of patients who had resided for at least 5 years within a radius of less than 20 km from uranium tailings storage facilities (Stepnogorsk area, Akmola region, Kazakhstan). The control group (n = 35) comprised patients with the same diagnosis living outside this zone. Results: The distribution of Fontaine stages was compared between groups before surgery and at 1 month postoperatively. Statistical analysis was performed using Pearson\u2019s chi-squared test. Before surgery, no statistically significant intergroup differences were found in the distribution of CLLI stages (\u03c72 = 3.688, df = 2, and p = 0.158). At 1 month after surgery, the control group demonstrated significantly better regression of ischemia stages: mild stages (I\u2013IIa) were observed in 51.4% of control patients versus 8.6% in the study group, while severe stages (III\u2013IV) persisted in 62.8% of the study group versus 22.9% of the control group (\u03c72 = 17.547, df = 4, and p = 0.002). Complete regression to stage I occurred only in the control group (2 patients, 5.7%). Conclusions: Patients with LEAD residing long-term in uranium legacy-affected areas showed less favorable early postoperative dynamics compared to patients living outside the zone of potential technogenic exposure. The observed association requires cautious interpretation, and further prospective studies with individual exposure assessment are warranted.<\/jats:p>","DOI":"10.3390\/jcm15134994","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:45:20Z","timestamp":1782722720000},"page":"4994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Postoperative Outcomes in Patients with Peripheral Artery Disease Residing in Uranium Legacy-Affected Areas: A Comparative Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7326-077X","authenticated-orcid":false,"given":"Kuralay","family":"Ilbekova","sequence":"first","affiliation":[{"name":"Scientific Research Institute of Radiobiology and Radiation Protection, NJSC \u201cAstana Medical University\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-563X","authenticated-orcid":false,"given":"Yerbol","family":"Dogalbayev","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Corporate Fund (CF) University Medical Center, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tairkhan","family":"Dautov","sequence":"additional","affiliation":[{"name":"Clinical Academic Department of Radiology and Nuclear Medicine, Corporate Fund (CF) University Medical Center, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-8086","authenticated-orcid":false,"given":"Viktor","family":"Zemlyanskiy","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Corporate Fund (CF) University Medical Center, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokan","family":"Sultanaliyev","sequence":"additional","affiliation":[{"name":"Center for Vascular Surgery, National Research Oncology Center, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irlan","family":"Sagandykov","sequence":"additional","affiliation":[{"name":"Center for Vascular Surgery, National Research Oncology Center, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Fursov","sequence":"additional","affiliation":[{"name":"Professor G.V. Tsoi Scientific and Educational Center of Surgery, NJSC \u201cAstana Medical University\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1640-1728","authenticated-orcid":false,"given":"Danara","family":"Ibrayeva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Radiobiology and Radiation Protection, NJSC \u201cAstana Medical University\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Bekenova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine No. 1, NJSC \u201cAstana Medical University\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2018.05.033","article-title":"Update on peripheral artery disease: Epidemiology and evidence-based facts","volume":"275","author":"Shu","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/j.jacc.2024.02.013","article-title":"2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS guideline for the management of lower extremity peripheral artery disease: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"83","author":"Gornik","year":"2024","journal-title":"J. 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