{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:46:46Z","timestamp":1782784006722,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Atrial fibrillation (AF) is a major risk factor for ischaemic stroke (IS) and adverse long-term outcomes. The impact of pre-existing versus newly diagnosed AF on prognosis after endovascular thrombectomy (EVT) is uncertain. Methods: We conducted a retrospective analysis of patients with IS admitted to Mersey and West Lancashire Teaching Hospitals NHS Trust between January 2016 and November 2023 who underwent EVT. Data were extracted from the Sentinel Stroke National Audit Programme and cross-referenced with hospital medical records. Patients were categorised into three groups based on AF status: no-AF, pre-existing AF, and new-AF. Outcomes included prolonged hospital length of stay (LOS) [\u226575th percentile], poor functional outcome (modified Rankin Scale [mRS] \u2265 3 at discharge), and all-cause mortality (in-hospital, at 30-day, and at 6-month mortality). Logistic regression and Cox proportional hazards models were used for analysis. Results: A total of 138 patients were included (mean \u00b1 SD for age: 67.9 \u00b1 13.9 years; 45.7% female). Hospital LOS was longest in the new-AF group (median 35.0 days [IQR: 6.0\u201353.0]) compared with the pre-existing AF group (18.0 days [6.0\u201342.0]), and the no-AF group (7.0 days [3.0\u201328.0]), p = 0.024. In adjusted logistic regression, new-AF was significantly associated with prolonged LOS (OR = 2.55, 95%CI: 1.01\u20136.45, p = 0.048) but showed no association with poor functional prognosis (p = 0.851). Cox regression analysis showed that AF status was not associated with mortality (p = 0.325). Conclusions: Newly diagnosed AF after stroke is associated with prolonged hospitalisation despite comparable rates of successful EVT results but had no effect on functional prognosis or risk of death.<\/jats:p>","DOI":"10.3390\/jcm15135065","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:55:11Z","timestamp":1782780911000},"page":"5065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Pre-Existing and Newly Diagnosed Atrial Fibrillation on Clinical Outcomes of Patients with Ischaemic Stroke Undergoing Endovascular Thrombectomy: Analysis of Local Data"],"prefix":"10.3390","volume":"15","author":[{"given":"Sandra","family":"Elsheikh","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool L7 8T, UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L14 3PE, UK"},{"name":"Mersey and West Lancashire Teaching Hospitals NHS Trust, Prescot L35 5DR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Irving","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool L7 8T, UK"},{"name":"Mersey and West Lancashire Teaching Hospitals NHS Trust, Prescot L35 5DR, UK"},{"name":"Health Research Institute, Edge Hill University, Ormskirk L39 4QP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-0546","authenticated-orcid":false,"given":"Andrew M.","family":"Hill","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool L7 8T, UK"},{"name":"Mersey and West Lancashire Teaching Hospitals NHS Trust, Prescot L35 5DR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool L7 8T, UK"},{"name":"Department of Clinical Medicine, Aalborg University, 9220 Aalborg, Denmark"},{"name":"Department of Cardiology, Lipidology and Internal Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmil H.","family":"Abdul-Rahim","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool L7 8T, UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L14 3PE, UK"},{"name":"Mersey and West Lancashire Teaching Hospitals NHS Trust, Prescot L35 5DR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alonso, A., Akin, I., Hochadel, M., Borggrefe, M., Lesch, H., Grau, A., Zahn, R., Lugenbiel, P., Schwarzbach, C.J., and Sueselbeck, T. 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