{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:14:52Z","timestamp":1783401292690,"version":"3.54.6"},"reference-count":55,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Irritable bowel syndrome (IBS) is among the most prevalent disorders of gut\u2013brain interaction, yet its implications for spine surgery remain poorly characterized. This narrative review examines how IBS influences symptom presentation and postoperative outcomes in spine surgery patients. Methods: We synthesized the neurobiologic, epidemiologic, and perioperative literature linking IBS with musculoskeletal pain, spine-related symptomatology, and surgical outcomes, drawing on spine-specific data where available and on related surgical and chronic-pain populations where it was not. Results: IBS is characterized by central sensitization, impaired descending inhibition, increased temporal summation, autonomic dysregulation, and a high prevalence of psychiatric comorbidity, which manifest as widespread hyperalgesia and symptom amplification that overlap with pain mechanisms common in spine surgery patients. Epidemiologic studies indicate that patients with IBS undergo musculoskeletal and spinal procedures at disproportionately high rates, reflecting both symptom burden and diagnostic uncertainty from viscerosomatic overlap. These same factors have been associated with greater postoperative pain, elevated opioid requirements, slower functional recovery, and reduced satisfaction after spine surgery, although direct IBS-specific spine data remain limited. IBS may also confound preoperative assessment by mimicking radicular, discogenic, or sacroiliac pain. Conclusions: IBS represents an under-recognized potential modifier of symptom localization, perioperative pain trajectories, and functional recovery in spine surgery. Greater awareness of IBS-related nociplastic and psychosocial mechanisms may improve preoperative evaluation, risk stratification, perioperative management, and the design of future outcome studies.<\/jats:p>","DOI":"10.3390\/jcm15135192","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:51:25Z","timestamp":1783003885000},"page":"5192","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Irritable Bowel Syndrome on Spine Surgery Outcomes: A Comprehensive Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Nicolas L.","family":"Carayannopoulos","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puru","family":"Sadh","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8977-8375","authenticated-orcid":false,"given":"Zvipo M.","family":"Chisango","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Jasti","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-1351","authenticated-orcid":false,"given":"Michael J.","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-4996","authenticated-orcid":false,"given":"Joseph E.","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-1186","authenticated-orcid":false,"given":"Jeffrey","family":"Okewunmi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6501-8687","authenticated-orcid":false,"given":"Jinseong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-5822","authenticated-orcid":false,"given":"John","family":"Czerwein","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eren O.","family":"Kuris","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce A.","family":"Basques","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-4139","authenticated-orcid":false,"given":"Alan H.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brown University, 1 Kettle Point Avenue, East Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/s41380-023-01972-w","article-title":"The neurobiology of irritable bowel syndrome","volume":"28","author":"Mayer","year":"2023","journal-title":"Mol. 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