{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:58:54Z","timestamp":1792205934475,"version":"4.4.0"},"reference-count":53,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2406005"],"award-info":[{"award-number":["2022YFC2406005"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Perioperative bleeding from cancellous bone remains a clinically relevant challenge in orthopaedic surgery. Bone wax has long been used as a simple and inexpensive mechanical hemostatic agent, but previous reviews have focused mainly on total joint arthroplasty or on the material history of bone wax and its substitutes. The broader clinical evidence across orthopaedic subspecialties has not been comprehensively mapped. Methods: This scoping review followed the Arksey and O\u2019Malley framework, with methodological refinements proposed by Levac et al., and was reported in accordance with PRISMA-ScR. Five electronic sources and grey literature were searched through May 2025. Clinical studies evaluating bone wax in orthopaedic surgery were eligible regardless of study design; a relevant clinical trial registry record with sufficient methodological detail was also retained to map ongoing evidence. Preclinical and purely material-based studies were excluded. The protocol was registered in the Open Science Framework (DOI: 10.17605\/OSF.IO\/K3ZAV). Results: Of 486 identified records, 15 met the inclusion criteria. Eight records concerned joint replacement, two spinal surgery, three excision of abnormal bony structures, and two sealing applications. The strongest comparative evidence came from arthroplasty, where bone wax was generally associated with reduced intraoperative or perioperative blood loss without clear evidence of adverse effects on early postoperative recovery outcomes reported in the included studies. Evidence for spinal and nontraditional applications was more heterogeneous and was derived mainly from small observational studies, case series, technical reports, or a trial registry record. Complications such as foreign-body reaction and chronic inflammation were described primarily in spine-related reports of retained nonabsorbable wax. Conclusions: Bone wax remains a useful and inexpensive adjunct for hemostasis in orthopaedic surgery. The strongest clinical evidence is concentrated in arthroplasty, whereas spinal and nontraditional applications remain supported by limited and heterogeneous data. Future research should clarify indication-specific benefits and risks and evaluate the safety and effectiveness of bioresorbable alternatives in well-designed clinical studies.<\/jats:p>","DOI":"10.3390\/jcm15135226","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:15:04Z","timestamp":1783091704000},"page":"5226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Applications and Emerging Roles of Bone Wax in Orthopaedic Surgery: A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Ruijiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China"},{"name":"Seventh Clinical Medical College, Capital Medical University, Beijing 100035, China"},{"name":"National Center for Orthopaedics, Beijing 100035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4568-3413","authenticated-orcid":false,"given":"Yimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China"},{"name":"National Center for Orthopaedics, Beijing 100035, China"},{"name":"Fourth School of Clinical Medicine, Peking University, Beijing 100035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-8279","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China"},{"name":"National Center for Orthopaedics, Beijing 100035, China"},{"name":"Fourth School of Clinical Medicine, Peking University, Beijing 100035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China"},{"name":"Seventh Clinical Medical College, Capital Medical University, Beijing 100035, China"},{"name":"National Center for Orthopaedics, Beijing 100035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China"},{"name":"Seventh Clinical Medical College, Capital Medical University, Beijing 100035, China"},{"name":"National Center for Orthopaedics, Beijing 100035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China"},{"name":"Seventh Clinical Medical College, Capital Medical University, Beijing 100035, China"},{"name":"National Center for Orthopaedics, Beijing 100035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.13107\/jocr.2024.v14.i11.4914","article-title":"Beyond Hemostasis: Understanding the Risks of Bone Wax in Orthopedic Surgery\u2014A Case Report","volume":"14","author":"Das","year":"2024","journal-title":"J. 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