{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:49:17Z","timestamp":1787870957954,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Recep Tayyip Erdo\u011fan University Development Foundation","award":["02026006010380"],"award-info":[{"award-number":["02026006010380"]}]},{"award":["02026006010380"],"award-info":[{"award-number":["02026006010380"]}],"id":[{"id":"https:\/\/ror.org\/0468j1635","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: This prospective observational study aimed to compare the efficacy of a novel bioceramic intracanal medicament (Bio-C Temp) with a conventional calcium hydroxide-based medicament (UltraCal XS) in reducing postoperative spontaneous pain and percussion sensitivity in patients with symptomatic irreversible pulpitis (SIP) with apical periodontitis (AP). Methods: Thirty-seven systemically healthy patients diagnosed with SIP with AP were included. The selected teeth were vital, single-rooted, single-canal maxillary or mandibular teeth presenting with prolonged moderate to severe pain in response to cold testing (Visual Analog Scale [VAS] \u2265 50 mm), moderate to severe percussion pain (VAS \u2265 50 mm), and a periapical index (PAI) score \u2264 2. Patients were randomly allocated to receive either Bio-C Temp (n = 19) or UltraCal XS (n = 18) as the intracanal medicament. Postoperative pain, percussion sensitivity, and analgesic consumption were recorded at 6, 12, and 24 h, and 3, 5, and 7 days. Data were analyzed using R statistical software (version 4.5.0). Statistical significance was set at p &lt; 0.05. Results: Both groups demonstrated a significant reduction in postoperative pain and percussion sensitivity compared with preoperative levels (p &lt; 0.05). By the end of the 7th day, the UltraCal XS group showed significantly lower spontaneous pain (p &lt; 0.001) and percussion sensitivity (p &lt; 0.001) than the Bio-C Temp group. Complete spontaneous pain relief was reported in 65% of the UltraCal XS group and 31% of the Bio-C Temp. However, no patient in either group achieved complete resolution of percussion sensitivity. Conclusions: UltraCal XS provided superior short-term postoperative pain relief and greater reduction in percussion sensitivity compared with the bioseramic medicament. Neither medicament fully resolved percussion sensitivity within 7 days.<\/jats:p>","DOI":"10.3390\/jcm15135274","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"5274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Bio-C Temp and Calcium Hydroxide as Intracanal Medicaments in Managing Postoperative Pain and Percussion Sensitivity in Symptomatic Irreversible Pulpitis: A Preliminary Prospective Observational Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1124-1905","authenticated-orcid":false,"given":"Banu","family":"Ar\u0131c\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Medeniyet University, 34956 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-5859","authenticated-orcid":false,"given":"Ahter","family":"\u015eanal \u00c7\u0131kman","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Recep Tayyip Erdogan University, 53100 Rize, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"\u00d6zceylan","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Recep Tayyip Erdogan University, 53100 Rize, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Medeniyet University, 34956 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1097\/j.pain.0000000000000613","article-title":"Updating the definition of pain","volume":"157","author":"Williams","year":"2016","journal-title":"Pain"},{"key":"ref_2","unstructured":"Berman, L.H., and Hargreaves, K.M. 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