{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:16:31Z","timestamp":1783350991765,"version":"3.54.6"},"reference-count":35,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"1\u00b73\u00b75 projects for Artificial Intelligence, West China Hospital, Sichuan University","award":["0040206107057"],"award-info":[{"award-number":["0040206107057"]}]},{"DOI":"10.13039\/501100004829","name":"Sichuan Science and Technology Program","doi-asserted-by":"publisher","award":["2024YFFK0240"],"award-info":[{"award-number":["2024YFFK0240"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan University and National College Student Innovation and Entrepreneurship Training Program","award":["X2026106100635"],"award-info":[{"award-number":["X2026106100635"]}]},{"name":"1\u00b73\u00b75 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["ZYAI24070"],"award-info":[{"award-number":["ZYAI24070"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Acute type A aortic dissection (ATAAD) has high preoperative mortality, and an interpretable multivariable model based on clinically accessible data is crucial for clinical risk stratification. Methods: The data for this study were obtained from West China Hospital, Sichuan University. Centroid regression was used to construct the predictive model, with logistic regression, classification and regression tree, explainable boosting machine and extreme gradient boosting as the reference. Variables were screened by iterative selection, the literature review and clinical experience. Model performance was evaluated by accuracy, sensitivity, precision, Youden\u2019s index, AUROC and AUPRC. Results: The vital signs and tests of 361 ATAAD patients during the first 24 h of their first admission were included in the final analysis. Centroid regression outperformed logistic regression, achieving accuracy (90.7% vs. 81.5%), sensitivity (0.813 vs. 0.741), specificity (0.983 vs. 0.900), Youden\u2019s index (0.796 vs. 0.641), AUROC (area under the receiver operating characteristic curve, 0.953 vs. 0.843) and AUPRC (area under the precision\u2013recall curve, 0.978 vs. 0.863) in the test set. It revealed that the use of \u03b1-blocker (the weights w = \u22121.20) and hydrochlorothiazide (w = \u22121.20), clinical features like dyspnea (w = \u22120.94), chest pain (w = 0.91) and lactate dehydrogenase (w = \u22120.95) were variables that had the greatest impact on model prediction. Conclusions: The centroid regression model not only has relatively high predictive performance and interpretability but also can be easily implemented in hospital systems to provide a practical and cost-effective tool for ATAAD preoperative risk stratification.<\/jats:p>","DOI":"10.3390\/jcm15135277","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"5277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Centroid Regression for Preoperative Risk Assessment of Acute Type A Aortic Dissection Based on Multivariate Clinical Data"],"prefix":"10.3390","volume":"15","author":[{"given":"Yiming","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-6201","authenticated-orcid":false,"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic Dissection (IRAD): New Insights into an Old Disease","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","article-title":"2024 ESC guidelines for the management of peripheral arterial and aortic diseases: Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), and the European Society of Vascular Medicine (ESVM)","volume":"45","author":"Mazzolai","year":"2024","journal-title":"Eur. 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