{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:13:24Z","timestamp":1783574004414,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The association between female reproductive factors and laryngopharyngeal reflux (LPR) remains poorly understood. This study investigated the relationship between reproductive history and LPR risk in women using a large nationally representative cohort. Methods: We conducted a nested case\u2013control study using linked data from the Korean National Health and Nutrition Examination Survey and the National Health Insurance Service database (2007\u20132017). Among 57,559 participants, 1347 women diagnosed with LPR were matched 1:1 with 1347 controls without reflux disease using propensity score matching based on age, income, and education level. Multivariable logistic regression analyses were performed to evaluate the associations between reproductive factors and LPR risk after adjustment for metabolic and lifestyle variables. Results: Women with a first childbirth at age \u226527 years had a significantly higher risk of LPR than those with earlier childbirth (adjusted odds ratio [aOR] 1.33, 95% confidence interval [CI] 1.08\u20131.63; p = 0.007). A menarche-to-first-birth interval of \u226517 years was also associated with an increased risk of LPR (aOR 1.56, 95% CI 1.15\u20132.15; p = 0.005). In addition, breastfeeding for &lt;12 months was independently associated with a higher risk of LPR (aOR 1.26, 95% CI 1.04\u20131.53; p = 0.019). These associations remained significant after adjustment for potential confounders. Conclusions: Female reproductive factors potentially reflecting cumulative hormonal exposure were independently associated with LPR risk in this nationally representative cohort. First delivery at age \u226527 years, a menarche-to-first-birth interval \u226517 years, and breastfeeding &lt;12 months were associated with LPR, suggesting that reproductive history should be considered when evaluating women with reflux-related symptoms.<\/jats:p>","DOI":"10.3390\/jcm15135279","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"5279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Female Reproductive Factors and Laryngopharyngeal Reflux: A National Population-Based Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-3088","authenticated-orcid":false,"given":"Kyung Hoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-024X","authenticated-orcid":false,"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-7783","authenticated-orcid":false,"given":"Hong Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-0448","authenticated-orcid":false,"given":"Mi Jung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-1255","authenticated-orcid":false,"given":"Jeong Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","article-title":"Validity and reliability of the reflux symptom index (RSI)","volume":"16","author":"Belafsky","year":"2002","journal-title":"J. Voice"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","article-title":"The validity and reliability of the reflux finding score (RFS)","volume":"111","author":"Belafsky","year":"2001","journal-title":"Laryngoscope"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archotol.131.4.315","article-title":"Validation of a quality-of-life instrument for laryngopharyngeal reflux","volume":"131","author":"Carrau","year":"2005","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"19160216251347602","DOI":"10.1177\/19160216251347602","article-title":"Treatment for Laryngopharyngeal Reflux Disease: A Systematic Review of Controlled Studies","volume":"54","author":"Lechien","year":"2025","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14689","DOI":"10.1111\/nmo.14689","article-title":"Raloxifene increases the risk of gastroesophageal reflux disease, Barrett\u2019s esophagus, and esophageal stricture in postmenopausal women with osteoporosis","volume":"35","author":"Liu","year":"2023","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/13697137.2022.2033203","article-title":"Impact of progesterone on the gastrointestinal tract: A comprehensive literature review","volume":"25","author":"Coquoz","year":"2022","journal-title":"Climacteric"},{"key":"ref_7","first-page":"799","article-title":"Data Resource Profile: The National Health Information Database of the National Health Insurance Service in South Korea","volume":"46","author":"Kim","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ije\/dyt228","article-title":"Data resource profile: The Korea National Health and Nutrition Examination Survey (KNHANES)","volume":"43","author":"Kweon","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cgh.2022.01.058","article-title":"Effect of Hormonal Replacement Therapy on Gastroesophageal Reflux Disease and its Complications in Postmenopausal Women","volume":"21","author":"Saleh","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0016-5085(78)90698-4","article-title":"Altered lower esophageal sphincter function during early pregnancy","volume":"74","author":"Fisher","year":"1978","journal-title":"Gastroenterology"},{"key":"ref_11","first-page":"143","article-title":"Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy","volume":"56","author":"Law","year":"2010","journal-title":"Can. Fam. Physician"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.gtc.2016.02.003","article-title":"Upper Gastrointestinal Tract Motility Disorders in Women, Gastroparesis, and Gastroesophageal Reflux Disease","volume":"45","author":"Zia","year":"2016","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1001\/archinte.168.16.1798","article-title":"Postmenopausal hormone use and symptoms of gastroesophageal reflux","volume":"168","author":"Jacobson","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"ref_14","first-page":"e67305","article-title":"Laryngopharyngeal Reflux Pathophysiology, Clinical Presentation, and Management: A Narrative Review","volume":"16","author":"Barham","year":"2024","journal-title":"Cureus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/j.1572-0241.2004.40170.x","article-title":"The role of gastric and duodenal agents in laryngeal injury: An experimental canine model","volume":"99","author":"Adhami","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_16","first-page":"e11180","article-title":"Is Estrogen a Curse or a Blessing in Disguise? Role of Estrogen in Gastroesophageal Reflux Disease","volume":"12","author":"Kang","year":"2020","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"G476","DOI":"10.1152\/ajpgi.00112.2019","article-title":"Sex differences in GABAergic neurotransmission to rat DMV neurons","volume":"317","author":"Jiang","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s00405-021-07201-w","article-title":"Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: Physiopathology and therapeutic targets","volume":"279","author":"Li","year":"2022","journal-title":"Eur. Arch. Otorhinolaryngol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/13\/5279\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:16:38Z","timestamp":1783570598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/13\/5279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":18,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15135279"],"URL":"https:\/\/doi.org\/10.3390\/jcm15135279","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}