{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:14:10Z","timestamp":1783419250422,"version":"3.54.6"},"reference-count":18,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Parathyroid hormone (PTH) is mainly regulated by calcium, vitamin D, and renal function, but metabolic factors may also influence its levels. The uric acid\/creatinine (UA\/Cr) ratio reflects uric acid metabolism and renal handling. This study evaluated its association with elevated PTH in adults without known parathyroid disease. Methods: This retrospective cross-sectional study included 244 adults undergoing routine biochemical evaluation. The uric acid-to-creatinine ratio (UA\/Cr) was calculated. Participants were categorized according to PTH levels (\u226465 pg\/mL vs. &gt;65 pg\/mL). Logistic regression analyses were performed to identify factors associated with elevated PTH levels. Results: A total of 244 individuals (mean age 40.6 \u00b1 11.7 years; 70.9% female) were included in the analysis. Participants with elevated PTH levels had significantly higher UA\/Cr ratios compared with those with normal PTH levels (8.93 \u00b1 1.82 vs. 7.47 \u00b1 1.79, p = 0.031). In univariate logistic regression analysis, UA\/Cr was associated with elevated PTH (OR 1.15, 95% CI 1.01\u20131.32, p = 0.043). In multivariable logistic regression analysis adjusting for vitamin D, magnesium, phosphorus, corrected calcium, age, sex, body mass index, and the estimated glomerular filtration rate, the UA\/Cr ratio remained significantly associated with elevated PTH levels (OR 1.41, 95% CI 1.036\u20131.66, p = 0.024). Conclusions: The UA\/Cr ratio was associated with elevated PTH levels in adults without known parathyroid disease, independently of vitamin D status, mineral metabolism parameters, and renal function. These findings suggest that the UA\/Cr ratio may help characterize a broader metabolic context associated with elevated PTH levels, rather than serving as a diagnostic marker. Further prospective studies are needed to clarify the clinical relevance and direction of this association.<\/jats:p>","DOI":"10.3390\/jcm15135285","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:04:49Z","timestamp":1783411489000},"page":"5285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between the Uric Acid-to-Creatinine Ratio and Elevated Parathyroid Hormone Levels in Adults Without Known Parathyroid Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Orhan","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sanko University Faculty of Medicine, Gaziantep 27470, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-8709","authenticated-orcid":false,"given":"Ahmet Ziya","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Health Sciences University Adana City Hospital, Adana 01370, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eray","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanko University Faculty of Medicine, Gaziantep 27470, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-0292","authenticated-orcid":false,"given":"Zeynel Abidin","family":"Sayiner","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Sanko University Faculty of Medicine, Gaziantep 27470, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41574-018-0115-0","article-title":"The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases","volume":"15","author":"Hannan","year":"2018","journal-title":"Nat. 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