{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:15:41Z","timestamp":1783538141725,"version":"3.55.0"},"reference-count":20,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Multiple organ dysfunction syndrome (MODS) is a serious complication and a leading cause of death in patients undergoing heart valve surgery. The main aim of the present study was to assess the predictive capacity of selected perioperative parameters, including Troponin T levels, to predict the occurrence of postoperative MODS and 30-day mortality in patients undergoing heart valve surgery. Methods: This prospective study included a group of patients with hemodynamically severe symptomatic valvular heart disease who underwent valve surgery. The primary endpoint was postoperative multiple organ dysfunction syndrome (MODS), defined as the dysfunction of at least two organs\/systems, including cardiogenic shock, perioperative stroke, respiratory failure requiring prolonged mechanical ventilation, and\/or postoperative acute kidney injury requiring renal replacement therapy. The secondary endpoint was death during the 30-day follow-up. Logistic regression was used to assess the relationships between the variables. Results: In total, 739 patients undergoing valvular heart surgery were included in this study. The primary end point was observed in 45 patients. Preoperative hemoglobin level (p = 0.01), red cell distribution width (RDW) (p = 0.001) and troponin T level measured on the first day after surgery (TnT II) (p &lt; 0.001) were independent predictors of the primary endpoint. EuroSCORE II (p = 0.002) and TnT II (p &lt; 0.001) were independent predictors of 30-day mortality. Conclusions: MODS is a clinical condition that is associated with a high risk of death. Troponin T levels measured within the first 24 h postoperatively may be useful in predicting postoperative MODS and 30-day mortality in patients undergoing heart valve surgery as a complement to commonly used risk calculators.<\/jats:p>","DOI":"10.3390\/jcm15145337","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:27:31Z","timestamp":1783531651000},"page":"5337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Markers of Myocardial Damage in Predicting Postoperative Multiple Organ Dysfunction Syndrome and 30-Day Mortality in Patients Undergoing Heart Valve Surgery"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-5612","authenticated-orcid":false,"given":"Piotr","family":"Duchnowski","sequence":"first","affiliation":[{"name":"Cardinal Wyszynski National Institute of Cardiology, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"\u015amigielski","sequence":"additional","affiliation":[{"name":"Cardinal Wyszynski National Institute of Cardiology, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Ku\u015bmierski","sequence":"additional","affiliation":[{"name":"Cardinal Wyszynski National Institute of Cardiology, 04-628 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, Y., Xiao, J., Duan, X., Lu, X., Gong, X., Chen, J., Xiong, M., Yin, S., Guo, X., and Wu, Z. (2021). The multivariable prognostic models for severe complications after heart valve surgery. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02268-z"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4103\/aca.ACA_60_17","article-title":"Risk Factors of Postcardiotomy Ventricular Dysfunction in Moderate-to-high Risk Patients Undergoing Open-heart Surgery","volume":"20","author":"Ellenberger","year":"2017","journal-title":"Ann. Card. Anaesth."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1177\/0885066619871452","article-title":"Multiple Organ Dysfunction Syndrome","volume":"35","author":"Gourd","year":"2020","journal-title":"J. Intensive Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1010-7940(99)00134-7","article-title":"European system for cardiac operative risk evaluation (EuroSCORE)","volume":"16","author":"Nashef","year":"1999","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.athoracsur.2016.01.105","article-title":"Comparison of EuroSCORE II, original EuroSCORE, and the society of thoracic surgeons risk score in cardiac surgery patients","volume":"102","author":"Ad","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.33963\/v.phj.99553","article-title":"Usefulness of myocardial damage biomarkers in predicting cardiogenic shock in patients undergoing heart valve surgery","volume":"82","author":"Duchnowski","year":"2024","journal-title":"Kardiol. Pol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Duchnowski, P., \u015amigielski, W., and Ko\u0142sut, P. (2025). Usefulness of Myocardial Injury Parameters in Predicting Prolonged Postoperative Use of Inotropes Drugs in Patients Undergoing Heart Valve Surgery. J. Clin. Med., 14.","DOI":"10.3390\/jcm14082719"},{"key":"ref_8","first-page":"100081","article-title":"Revised Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery (STROCSS) Guideline: An update for the age of Artificial Intelligence","volume":"10","author":"Agha","year":"2025","journal-title":"Prem. J. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/cc8153","article-title":"Clinical review: Practical recommendations on the management of perioperative heart failure in cardiac surgery","volume":"14","author":"Mebazaa","year":"2010","journal-title":"Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_11","first-page":"ehaf194","article-title":"2025 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"46","author":"Praz","year":"2025","journal-title":"ESC\/EACTS Sci. Doc. Group. Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/icvts\/ivw060","article-title":"Predictive value of high-sensitivity troponin T in addition to EuroSCORE II in cardiac surgery","volume":"23","author":"Mildh","year":"2016","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.athoracsur.2007.11.074","article-title":"Do we need separate risk stratification models for hospital mortality after heart valve surgery?","volume":"85","author":"Kappetein","year":"2008","journal-title":"Ann. Thorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.jacc.2021.09.864","article-title":"Contemporary Management of Severe Symptomatic Aortic Stenosis. EORP VHD II Registry Investigators Group","volume":"78","author":"Duchnowski","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","first-page":"455","article-title":"Performance of the EuroSCORE II and the Society of Thoracic Surgeons Score in patients undergoing aortic valve replacement for aortic stenosis","volume":"56","author":"Kuwaki","year":"2015","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/icvts\/ivt550","article-title":"Prospective validation of EuroSCORE II in patients undergoing cardiac surgery in Argentinean Centres","volume":"18","author":"Borracci","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.21037\/jtd.2019.04.48","article-title":"Performance of the EuroSCORE II and the Society of Thoracic Surgeons score in patients undergoing aortic valve replacement for aortic stenosis","volume":"11","author":"Duchnowski","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/CIRCOUTCOMES.111.000018","article-title":"Performance of the EuroSCORE Models in Emergency Cardiac Surgery","volume":"6","author":"Grant","year":"2013","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/ejcts\/ezs406","article-title":"Validation of EuroSCORE II in a modern cohort of patients undergoing cardiac surgery","volume":"43","author":"Chalmers","year":"2013","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Duchnowski, P., \u015amigielski, W., and Ko\u0142sut, P. (2025). High-Sensitivity Troponin T as a Predictor of Prolonged Intensive Care Unit Stay and Worse Treatment Outcomes in Patients Undergoing Heart Valve Surgery. J. Clin. Med., 14.","DOI":"10.3390\/jcm14144989"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5337\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:51:10Z","timestamp":1783533070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":20,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145337"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145337","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]}}}