{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:22:19Z","timestamp":1783596139262,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cPioneer\u201d and \u201cLeading Goose\u201d R&D Program of Zhejiang Province","award":["2024C03181"],"award-info":[{"award-number":["2024C03181"]}]},{"name":"\u201cPioneer\u201d and \u201cLeading Goose\u201d R&D Program of Zhejiang Province","award":["2025C01106"],"award-info":[{"award-number":["2025C01106"]}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY860"],"award-info":[{"award-number":["2022KY860"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: The purpose of this study was to evaluate the clinical effects and safety for cancer treatment of neoadjuvant chemotherapy (NACT) when combined with laparoscopic fertility-sparing (anatomical preservation) surgery in pediatric patients who have large malignant ovarian germ cell tumors (MOGCTs). Methods: We performed a retrospective analysis on seven young female patients with a median age of 8.8 years (range: 10 months to 13.4 years). The patients were treated between 2015 and 2023, and all of them received two to three cycles of JEB (carboplatin, etoposide, and bleomycin) regimen as NACT. After the NACT, these patients had laparoscopic (n = 7) unilateral salpingo-oophorectomy. Results: Neoadjuvant chemotherapy (NACT) achieved a median reduction in tumor volume of 91% (range: 85% to 97%). All the procedures were completed successfully and there was no need to convert to open surgery. The median operative time was 85 min (range: 70 to 120 min), and the blood loss was minimal. The median blood loss was 10 mL, with a range of 5 to 50 mL. In patients with yolk sac tumors, alpha-fetoprotein (AFP) levels returned to normal within a median of 20 days after the operation. With a median follow-up of 54 months (range: 18 to 118 months), all the patients had 100% disease-free survival. Conclusions: This study suggests that NACT combined with laparoscopic fertility-sparing (anatomical preservation) surgery may be effective and appears promising for selected pediatric patients with MOGCTs.<\/jats:p>","DOI":"10.3390\/jcm15145366","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:16:22Z","timestamp":1783592182000},"page":"5366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laparoscopic Surgery for Pediatric Malignant Ovarian Germ Cell Tumors After Neoadjuvant Chemotherapy: A Single-Center Retrospective Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Jiabin","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-1728","authenticated-orcid":false,"given":"Jieni","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0930-0230","authenticated-orcid":false,"given":"Xuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-8543","authenticated-orcid":false,"given":"Lifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinbing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-2475","authenticated-orcid":false,"given":"Jinhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"},{"name":"Department of Oncology Surgery, Children\u2019s Hospital, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101670","DOI":"10.1016\/j.ijgc.2025.101670","article-title":"Controversies in malignant ovarian germ cell tumors","volume":"35","author":"Seckl","year":"2025","journal-title":"Int. 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Steril."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5366\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:37:12Z","timestamp":1783593432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":30,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145366"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145366","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}