{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:23:31Z","timestamp":1783596211744,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Tension-type headache (TTH) and low back pain (LBP) are common chronic pain disorders associated with altered mechanical pain sensitivity, but direct comparison of regional pressure pain threshold (PPT) patterns remains limited. Methods: This cross-sectional comparative study included 600 participants: 200 patients with TTH, 200 patients with LBP, and 200 healthy controls. PPT was assessed using digital pressure algometry in cranial, lumbar, and lower-extremity regions. Each point was tested three times, and mean regional values were calculated. Between-group differences were analyzed using one-way ANOVA. ANCOVA models were additionally adjusted for age, sex, and BMI, and patient-only multivariable regression models were adjusted for age, sex, BMI, pain intensity, and symptom duration. Results: Significant differences were observed in all examined regions (all p &lt; 0.001). Patients with TTH had the lowest cranial PPT values, whereas patients with LBP showed the lowest lumbar PPT values. Both pain groups also demonstrated significantly reduced PPT values in anatomically distant regions compared with healthy controls. These regional differences remained significant after adjustment for relevant demographic, anthropometric, and clinical variables. Conclusions: TTH and LBP demonstrate distinct regional PPT profiles while sharing a pattern of extraregional mechanical hypersensitivity. These findings may be compatible with broader alterations in nociceptive processing, although central sensitization was not directly assessed.<\/jats:p>","DOI":"10.3390\/jcm15145368","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:16:22Z","timestamp":1783592182000},"page":"5368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional and Extraregional Pressure Pain Threshold Patterns in Tension-Type Headache and Low Back Pain: A Cross-Sectional Comparative Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9656-1299","authenticated-orcid":false,"given":"Aleksandar","family":"Kopitovic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Department of Neurology, University Clinical Center of Vojvodina, 1-9 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-0921","authenticated-orcid":false,"given":"Filip","family":"Katanic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Special Gynecology Hospital Ferona, 19 Sarplaninska Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5303-1731","authenticated-orcid":false,"given":"Sandro","family":"Kalember","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Special Gynecology Hospital Ferona, 19 Sarplaninska Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7476-3591","authenticated-orcid":false,"given":"Nina","family":"Vico Katanic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Department of Anesthesia, Intensive Care and Pain Therapy, University Clinical Center of Vojvodina, 1-9 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Katanic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Health Center Novi Sad, 75 Bulevar Cara Lazara Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lucic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Department of Neurology, University Clinical Center of Vojvodina, 1-9 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-6608","authenticated-orcid":false,"given":"Ivica","family":"Lalic","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University Business Academy, 5 Trg Mladenaca Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-8209","authenticated-orcid":false,"given":"Svetlana","family":"Simic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 3 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"},{"name":"Department of Neurology, University Clinical Center of Vojvodina, 1-9 Hajduk Veljkova Street, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2665-9913(23)00098-X","article-title":"Global, regional, and national burden of low back pain, 1990\u20132020, its attributable risk factors, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021","volume":"5","author":"Ferreira","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/14737175.2020.1780121","article-title":"Current perspectives on sex differences in tension-type headache","volume":"20","year":"2020","journal-title":"Expert Rev. 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