{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:57:37Z","timestamp":1785430657877,"version":"3.56.0"},"reference-count":26,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Korean government","doi-asserted-by":"publisher","award":["RS-2024-00342613"],"award-info":[{"award-number":["RS-2024-00342613"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2024-00342613"],"award-info":[{"award-number":["RS-2024-00342613"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003665","name":"National IT Industry Promotion Agency","doi-asserted-by":"crossref","award":["PJT-26-040282"],"award-info":[{"award-number":["PJT-26-040282"]}],"id":[{"id":"10.13039\/501100003665","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PJT-26-040282"],"award-info":[{"award-number":["PJT-26-040282"]}],"id":[{"id":"https:\/\/ror.org\/026v53e29","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Prior studies linking fatty liver-related phenotypes to aortic disease have mainly focused on abdominal aortic aneurysm and used earlier nomenclature. We examined associations of metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiometabolic risk factor (CMRF) count with aortic aneurysm and aortic dissection. Methods: We analyzed 240,074 adults from the 2009\u20132010 Korean National Health Insurance Service health-screening database after exclusions. Steatotic liver disease was assessed using the Fatty Liver Index, and MASLD was defined as steatotic liver disease with at least one CMRF. Outcomes were identified using claims-based International Classification of Diseases, 10th Revision codes. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. Results: Over a median follow-up of 9.6 years, 1018 aortic aneurysm events and 285 aortic dissection events were recorded. Incidence rates in the MASLD and reference groups were 0.54 versus 0.21 for aortic aneurysm and 0.15 versus 0.04 for aortic dissection per 1000 person-years. Compared with individuals without steatotic liver disease and without CMRFs, MASLD was associated with higher risks of aortic aneurysm (adjusted HR, 1.58; 95% CI, 1.14\u20132.18) and aortic dissection (adjusted HR, 2.12; 95% CI, 1.03\u20134.38). Compared with individuals without steatotic liver disease but with CMRFs, MASLD remained associated with aortic aneurysm, but not aortic dissection. Higher CMRF count was associated with aortic aneurysm. Conclusions: MASLD and higher CMRF count were associated with incident aortic aneurysm, whereas findings for aortic dissection were less consistent. Further studies with more precise liver and aortic phenotyping are warranted.<\/jats:p>","DOI":"10.3390\/jcm15145453","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:53:58Z","timestamp":1783932838000},"page":"5453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Risk of Aortic Aneurysm and Dissection: A Nationwide Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0997-8987","authenticated-orcid":false,"given":"Na Kyung","family":"Ha","sequence":"first","affiliation":[{"name":"Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Seok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1001\/jama.2025.19615","article-title":"Metabolic dysfunction-associated steatotic liver disease in adults: A review","volume":"335","author":"Tilg","year":"2026","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/HEP.0000000000000735","article-title":"Metabolic dysfunction-associated steatotic liver disease and the heart","volume":"82","author":"Driessen","year":"2025","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4070\/kcj.2025.0212","article-title":"Cardiovascular implications in metabolic dysfunction-associated steatotic liver disease (MASLD): A state-of-the-art review","volume":"56","author":"Suresh","year":"2026","journal-title":"Korean Circ. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: Aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"117329","DOI":"10.1016\/j.atherosclerosis.2023.117329","article-title":"Metabolic syndrome and the risk of abdominal aortic aneurysm: A nationwide cohort study","volume":"386","author":"Cho","year":"2023","journal-title":"Atherosclerosis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12933-024-02385-x","article-title":"Association of triglyceride-glucose index with the risk of incident aortic dissection and aneurysm: A large-scale prospective cohort study in UK Biobank","volume":"23","author":"Tian","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.numecd.2023.11.004","article-title":"Association between metabolic dysfunction-associated fatty liver disease and abdominal aortic aneurysm","volume":"34","author":"Jia","year":"2024","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wang, X., Sun, J., Chang, N., Liu, M., and Zhang, S. (2025). Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: A multicenter study. BMC Med. Imaging, 25.","DOI":"10.1186\/s12880-025-01559-7"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.23838\/pfm.2021.00135","article-title":"National General Health Screening Program in Korea: History, current status, and future direction","volume":"6","author":"Shin","year":"2022","journal-title":"Precis. Future Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e016640","DOI":"10.1136\/bmjopen-2017-016640","article-title":"Cohort profile: The National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea","volume":"7","author":"Seong","year":"2017","journal-title":"BMJ Open"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A., and Tiribelli, C. (2006). The fatty liver index: A simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol., 6.","DOI":"10.1186\/1471-230X-6-33"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/gutjnl-2023-331003","article-title":"Metabolic dysfunction-associated steatotic liver disease and risk of cardiovascular disease","volume":"73","author":"Lee","year":"2024","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Shine, B.-K., Son, M., Moon, S.Y., and Han, S.-H. (2025). Metabolic dysfunction-associated steatotic liver disease and the risk of chronic periodontitis: A nationwide cohort study. Nutrients, 17.","DOI":"10.3390\/nu17010125"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lee, Y.H., Bang, H., Park, Y.M., Bae, J.C., Lee, B.-W., Kang, E.S., Cha, B.S., Lee, H.C., Balkau, B., and Lee, W.-Y. (2014). Non-laboratory-based self-assessment screening score for non-alcoholic fatty liver disease: Development, validation and comparison with other scores. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107584"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), and European Association for the Study of Obesity (EASO) (2024). EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). Obes. Facts, 17, 374\u2013444.","DOI":"10.1159\/000539371"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Son, N., Choi, E., Chung, S.Y., Han, S.Y., and Kim, B. (2022). Risk of aortic aneurysm and aortic dissection with the use of fluoroquinolones in Korea: A nested case\u2013control study. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02488-x"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease","volume":"42","author":"Lee","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejvs.2024.05.042","article-title":"Editor\u2019s Choice\u2014Glycaemic status and risk of abdominal aortic aneurysm: A nationwide cohort study of four million adults using Korean national health screening data","volume":"68","author":"Koo","year":"2024","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.avsg.2024.07.105","article-title":"Associations between type 2 diabetes mellitus, metabolic traits, and abdominal aortic aneurysm: A cross-ethnic Mendelian randomization analysis","volume":"110","author":"Niu","year":"2025","journal-title":"Ann. Vasc. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101682","DOI":"10.1016\/j.jacadv.2025.101682","article-title":"Pathobiology of aortic aneurysms and dissections: Synthesis of recent investigations and evolving insights","volume":"4","author":"Buja","year":"2025","journal-title":"JACC Adv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"w14489","DOI":"10.4414\/smw.2017.14489","article-title":"Acute aortic dissection: Pathogenesis, risk factors and diagnosis","volume":"147","author":"Gawinecka","year":"2017","journal-title":"Swiss Med. Wkly."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1507\/endocrj.EJ17-0466","article-title":"Validation of simple indexes for nonalcoholic fatty liver disease in western China: A retrospective cross-sectional study","volume":"65","author":"Zhu","year":"2018","journal-title":"Endocr. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4174\/astr.2023.104.3.170","article-title":"Validation of I71.3 code for ruptured abdominal aortic aneurysm in Korea: Misplaced diagnosis in claims data","volume":"104","author":"Jo","year":"2023","journal-title":"Ann. Surg. Treat. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5453\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:10:39Z","timestamp":1784002239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":26,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145453"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145453","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]}}}