{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:08:11Z","timestamp":1783937291845,"version":"3.55.0"},"reference-count":25,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Actelion Pharma, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Despite advances in transcatheter therapy, surgery remains the gold standard treatment for sinus venosus defect (SVD). However, data on long-term outcomes following surgical repair remain scarce. This multicenter study evaluates the long-term outcomes of surgically treated SVD patients with comparison to surgically and percutaneously treated secundum atrial septal defect (ASD). Methods: Clinical, surgical, imaging and invasive data were retrospectively reviewed from eight centers in Europe. Results: A total of 209 patients were included, of whom 80 were surgically treated SVD, 57 surgically treated secundum ASD and 72 percutaneously treated secundum ASD. Operation for SVD mainly occurred in adulthood, with a median age of 28.5 years (2\u201368 years). During follow-up, the observed reoperation rate was higher in the SVD cohort than ASD cohorts (p = 0.033), despite shorter follow-up period in the SVD cohort. Reoperations, in the SVD cohort, occurred at a median of 28 years (1\u201350 years) after index surgery. The need for pacemaker implantation was similar between groups (p = 0.301). The prevalence of late atrial fibrillation did not differ between groups (p = 0.588). Surgically treated SVD tended to have a higher prevalence of atrial flutter and atrial tachycardia, with a significantly higher rate of electrophysiological studies than percutaneously treated secundum ASD (p = 0.013), similar to surgically treated secundum ASD (p = 0.405). Conclusions: Long-term follow-up of surgically treated SVD is essential to monitor for reintervention and arrhythmic complications.<\/jats:p>","DOI":"10.3390\/jcm15145472","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:53:58Z","timestamp":1783932838000},"page":"5472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Postoperative Outcomes of Sinus Venosus Defect"],"prefix":"10.3390","volume":"15","author":[{"given":"Mariama","family":"Touray","sequence":"first","affiliation":[{"name":"Service of Cardiology, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3521","authenticated-orcid":false,"given":"Magalie","family":"Ladouceur","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Centre de R\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes, M3C, Department of Cardiology, H\u00f4pital Europ\u00e9en Georges Pompidou, H\u00f4pitaux de Paris, 75015 Paris, France"},{"name":"Department of Congenital Heart Disease, M3C Network for Complex Congenital Heart Diseases, Marie Lannelongue Hospital, Paris-Saclay University, 92350 Le Plessis-Robinson, France"},{"name":"INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies (HPPIT), Paris Saclay University, 92350 Le Plessis-Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-288X","authenticated-orcid":false,"given":"Judith","family":"Bouchardy","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1005 Lausanne, Switzerland"},{"name":"Cardiology Unit, University Hospitals of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8929","authenticated-orcid":false,"given":"Markus","family":"Schwerzmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Congenital Heart Disease, Inselspital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-6108","authenticated-orcid":false,"given":"Matthias","family":"Greutmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University of Zurich, 8006 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0821-3196","authenticated-orcid":false,"given":"Daniel","family":"Tobler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Basel, University of Basel, 4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vienna General Hospital, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Blanche","sequence":"additional","affiliation":[{"name":"Cardiology Unit, University Hospitals of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-9285","authenticated-orcid":false,"given":"Etienne","family":"Pruvot","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-249X","authenticated-orcid":false,"given":"Nicole","family":"Sekarski","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Unit, Women-Mother-Child Department, Lausanne University Hospital, University of Lausanne, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-291X","authenticated-orcid":false,"given":"Tobias","family":"Rutz","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1093\/eurheartj\/ehab646","article-title":"Atrial septal defect in adulthood: A new paradigm for congenital heart disease","volume":"43","author":"Brida","year":"2022","journal-title":"Eur. 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Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5472\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:13:55Z","timestamp":1783934035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":25,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145472"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145472","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}