{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:04:54Z","timestamp":1783940694347,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Contrast sensitivity (CS) is an important measure of visual function, particularly in patients with glaucoma. While minimally invasive glaucoma surgery (MIGS) combined with cataract surgery is increasingly performed, postoperative CS outcomes\u2014especially comparing enhanced monofocal intraocular lenses (emIOLs) and monofocal intraocular lenses (mIOLs)\u2014remain unclear. This study aimed to compare postoperative CS between emIOL and mIOL in eyes undergoing combined MIGS and cataract surgery. Methods: This retrospective observational study included eyes that underwent combined MIGS and cataract surgery at a single center. CS was measured preoperatively and at 2\u20133 months postoperatively using the imo vifa system and quantified as the area under the log contrast sensitivity function (AULCSF). Clinical parameters were compared between IOL types using univariate and multivariate analyses, including a generalized linear mixed model (GLMM). Propensity score matching was performed to adjust for baseline differences. Results: A total of 140 eyes (71 emIOL, 69 mIOL) were analyzed. CS significantly improved postoperatively in both groups (p &lt; 0.001). In multivariate analysis, IOL type was not significantly associated with CS (p = 0.10), whereas postoperative status was associated with improved CS (p = 0.01). CS measurement pattern significantly affected results, but no interaction between IOL type and measurement pattern was observed. After propensity score matching, postoperative CS was higher in the emIOL group (p = 0.01); however, multivariate analysis still showed no significant association between IOL type and CS (p = 0.20). Conclusions: CS improved after combined MIGS and cataract surgery regardless of IOL type. No independent difference in CS was observed between emIOL and mIOL, suggesting that emIOL may provide comparable visual quality in terms of CS, even in glaucoma patients.<\/jats:p>","DOI":"10.3390\/jcm15145477","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:51:09Z","timestamp":1783936269000},"page":"5477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast Sensitivity After Combined MIGS and Cataract Surgery: A Comparison of Monofocal and Enhanced Monofocal Intraocular Lenses"],"prefix":"10.3390","volume":"15","author":[{"given":"Keigo","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinako","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisako","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4995-8779","authenticated-orcid":false,"given":"Kana","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-7203","authenticated-orcid":false,"given":"Masaki","family":"Tanito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0420.1996.tb00686.x","article-title":"Changes of visual function and visual ability in daily life following cataract surgery","volume":"74","author":"Abrahamsson","year":"1996","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1477-7525-12-16","article-title":"The impact of cataract surgery on vision-related quality of life for bilateral cataract patients in Ho Chi Minh City, Vietnam: A prospective study","volume":"12","author":"To","year":"2014","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/eye.2015.147","article-title":"Impact of cataract surgery on vision-related life performances: The usefulness of Real-Life Vision Test for cataract surgery outcomes evaluation","volume":"29","author":"Ni","year":"2015","journal-title":"Eye"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3928\/1081597X-20200212-01","article-title":"Extended Depth of Focus Versus Monofocal IOLs: Objective and Subjective Visual Outcomes","volume":"36","author":"Pedrotti","year":"2020","journal-title":"J. Refract. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mencucci, R., Morelli, A., Cennamo, M., Roszkowska, A.M., and Favuzza, E. (2023). Enhanced Monofocal Intraocular Lenses: A Retrospective, Comparative Study Between Three Different Models. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103588"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1177\/11206721221146675","article-title":"Real world outcomes of the new Tecnis Eyhance IOL","volume":"33","author":"Gigon","year":"2023","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2147\/OPTH.S438599","article-title":"Clinical Results and Factors Affecting Visual Function in Eyes Implanted with an Enhanced Monofocal Intraocular Lens","volume":"17","author":"Negishi","year":"2023","journal-title":"Clin. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/j.jcrs.0000000000001641","article-title":"Comparative evaluation of clinical results and patient-reported outcomes of enhanced monofocal and conventional monofocal intraocular lenses","volume":"51","author":"Kabura","year":"2025","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"24377","DOI":"10.1038\/s41598-024-75008-w","article-title":"Efficacy of enhanced monofocal intraocular lens in combined phacovitrectomy for patients with photoreceptor-preserving epiretinal membrane","volume":"14","author":"Jeong","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00061198-200304000-00008","article-title":"Comparison of contrast sensitivity, visual acuity, and Humphrey visual field testing in patients with glaucoma","volume":"12","author":"Hawkins","year":"2003","journal-title":"J. Glaucoma"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41598-022-27262-z","article-title":"Contrast sensitivity in glaucoma patients with visual field defects at different locations","volume":"13","author":"Jang","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00061198-200304000-00009","article-title":"Quality of life in glaucoma and its relationship with visual function","volume":"12","author":"Nelson","year":"2003","journal-title":"J. Glaucoma"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Nakano, R., Igarashi, R., Akagi, T., Sakaue, Y., Iikawa, R., Tazawa, A., Kamada, K., Arimatsu, M., Togano, T., and Fukuchi, T. (2025). Correlation between contrast sensitivity and national eye institute visual function questionnaire (NEI VFQ-25) Rasch scores in patients with open-angle glaucoma: A cross-sectional study. BMC Ophthalmol., 25.","DOI":"10.1186\/s12886-025-03928-w"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/OPTH.S152406","article-title":"Microhook ab interno trabeculotomy, a novel minimally invasive glaucoma surgery","volume":"12","author":"Tanito","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ophtha.2010.07.007","article-title":"Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract","volume":"118","author":"Samuelson","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ophtha.2015.03.031","article-title":"A Randomized Trial of a Schlemm\u2019s Canal Microstent with Phacoemulsification for Reducing Intraocular Pressure in Open-Angle Glaucoma","volume":"122","author":"Pfeiffer","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.2147\/OPTH.S532731","article-title":"Post-Operative Outcomes at One Year of STREAMLINE Microinvasive Glaucoma Surgery Combining Micro-Goniotomy and Focal Ab-Interno Canaloplasty","volume":"19","author":"Sharma","year":"2025","journal-title":"Clin. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.2147\/OPTH.S381368","article-title":"Clinical and Visual Field Outcomes Following Minimally Invasive Glaucoma Surgery Combined with Cataract Surgery","volume":"16","author":"Turner","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12325-020-01543-3","article-title":"Comparison of Surgical Outcomes Between Microhook Ab Interno Trabeculotomy and Goniotomy with the Kahook Dual Blade in Combination with Phacoemulsification: A Retrospective, Comparative Case Series","volume":"38","author":"Aoki","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/bjo-2025-327359","article-title":"Long-term comparative outcomes of Hydrus versus iStent inject microinvasive glaucoma surgery implants combined with cataract surgery","volume":"110","author":"Tan","year":"2025","journal-title":"Br. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10384-017-0531-z","article-title":"Effectiveness and safety of combined cataract surgery and microhook ab interno trabeculotomy in Japanese eyes with glaucoma: Report of an initial case series","volume":"61","author":"Tanito","year":"2017","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Takayanagi, Y., Ichioka, S., Ishida, A., Tsutsui, A., and Tanito, M. (2021). Fellow-Eye Comparison Between Phaco-Microhook Ab-Interno Trabeculotomy and Phaco-iStent Trabecular Micro-Bypass Stent. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102129"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.18240\/ijo.2025.04.05","article-title":"Comparison of visual acuity and optical quality between higher-order aspheric monofocal and standard introcular lenses","volume":"18","author":"Janekova","year":"2025","journal-title":"Int. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Noguchi, S., Nakakura, S., Noguchi, A., and Tabuchi, H. (2025). Effectiveness of Enhanced Monofocal Intraocular Lens with Mini-Monovision in Improving Visual Acuity. J. Clin. Med., 14.","DOI":"10.3390\/jcm14134517"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/j.jcrs.0000000000001734","article-title":"Comparison of visual performance among three higher-order aspheric enhanced monofocal intraocular lenses and a standard aspheric monofocal lens","volume":"51","author":"Hayashi","year":"2025","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s00417-023-06010-7","article-title":"A novel quick contrast sensitivity function test in Chinese adults with myopia and its related parameters","volume":"261","author":"Ye","year":"2023","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kamiya, K., Fujimura, F., Kawamorita, T., Ando, W., Iida, Y., and Shoji, N. (2021). Factors Influencing Contrast Sensitivity Function in Eyes with Mild Cataract. J. Clin. Med., 10.","DOI":"10.3390\/jcm10071506"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"46706","DOI":"10.1038\/srep46706","article-title":"Evaluation of the precision of contrast sensitivity function assessment on a tablet device","volume":"7","author":"Dorr","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Fernandez, J., Rocha-de-Lossada, C., Zamorano-Martin, F., Rodriguez-Calvo-de-Mora, M., and Rodriguez-Vallejo, M. (2023). Positioning of enhanced monofocal intraocular lenses between conventional monofocal and extended depth of focus lenses: A scoping review. BMC Ophthalmol., 23.","DOI":"10.1186\/s12886-023-02844-1"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1038\/s41598-025-87282-3","article-title":"Efficacy and safety of the enhanced monofocal intraocular lens in glaucoma of varying severity","volume":"15","author":"Kim","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s10792-024-03350-z","article-title":"Effect of enhanced monofocal intraocular lenses on glaucoma patients\u2019 foveal threshold","volume":"44","author":"Tojo","year":"2024","journal-title":"Int. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chung, H.S., Jang, J.H., Lee, H., Kim, J.Y., and Tchah, H. (2023). Clinical outcomes after implantation of a new monofocal intraocular lens with enhanced intermediate function in patients with preperimetric glaucoma. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1260298"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s10384-025-01321-0","article-title":"Age-stratified comparison of visual function between eyes with an enhanced monofocal intraocular lens and phakic eyes","volume":"70","author":"Hayashi","year":"2026","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joco.2016.09.003","article-title":"Combined cataract extraction and trabeculotomy by the internal approach for coexisting cataract and open-angle glaucoma","volume":"29","author":"Hashemian","year":"2017","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ogla.2022.08.012","article-title":"Three-Year Outcomes of a Schlemm Canal Microstent (Hydrus Microstent) with Concomitant Phacoemulsification in Open-Angle Glaucoma","volume":"6","author":"Salimi","year":"2023","journal-title":"Ophthalmol. Glaucoma"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5477\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:09:40Z","timestamp":1783937380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":35,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145477"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145477","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}