{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:07:31Z","timestamp":1784268451835,"version":"3.55.0"},"reference-count":15,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinodevice","award":["K-BB001-EXERTION"],"award-info":[{"award-number":["K-BB001-EXERTION"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: COPD is a chronic, progressive, heterogeneous disease. While volume-reducing procedures are available for advanced emphysema-predominant COPD, options remain limited for chronic bronchitis-predominant COPD. Broncho Muco Cleaner Balloon (BMCB) dilation therapy is a method that aims to provide clinical and functional benefit by causing damage to the goblet cells in the bronchial system. This study evaluated the safety and effects of this method on exacerbations, dyspnea and exercise capacity in chronic bronchitis-predominant COPD. Methods: In this prospective interventional study, a total of 35 patients with stage II\u2013IV chronic bronchitis-predominant COPD underwent BMCB therapy. The results of 25 patients who completed the 12-month-follow-up period were analyzed. Dyspnea was assessed using the modified Medical Research Council (mMRC) scale, pulmonary function with spirometry, exercise capacity with the 6 min walk test (6MWT), and quality of life with the St. George\u2019s Respiratory Questionnaire (SGRQ). Results: At the 12-month follow-up, there were significant improvements in mMRC scores (p &lt; 0.001), moderate\/severe exacerbations (p = 0.022), and in the symptom, activity, impact, and total scores of the SGRQ (all p &lt; 0.05). However, no significant changes were observed in FEV1 (p = 0.291) or 6MWT distance (p = 0.420). No procedure-related mortality occurred during the study period. In one patient, bradycardia was observed during the procedure, but it did not cause hemodynamic instability. Conclusions: Based on the results of this study, BMCB dilation therapy in patients with chronic bronchitis-predominant COPD appears to be safe. It reduces the perceived severity of dyspnea, decreases the number of moderate\/severe exacerbations, and improves quality of life, without causing significant changes in pulmonary function or exercise capacity.<\/jats:p>","DOI":"10.3390\/jcm15145607","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:32:17Z","timestamp":1784266337000},"page":"5607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Broncho Muco Cleaner Balloon Dilation Therapy in Chronic Bronchitis-Predominant COPD: A Prospective Interventional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-0020","authenticated-orcid":false,"given":"Erdo\u011fan","family":"\u00c7etinkaya","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00c7\u00f6rt\u00fck","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2401-9385","authenticated-orcid":false,"given":"Demet","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-9322","authenticated-orcid":false,"given":"Fulya Senem","family":"Karaahmeto\u011flu","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Hamidiye Institute of Health Sciences, University of Health Sciences, Istanbul 34668, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-7755","authenticated-orcid":false,"given":"Zeynep Bet\u00fcl","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Hamidiye Institute of Health Sciences, University of Health Sciences, Istanbul 34668, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"Demirkol","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2025, August 19). 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Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5607\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:37:56Z","timestamp":1784266676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":15,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145607"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145607","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]}}}