{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:02:31Z","timestamp":1784696551257,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Stenotrophomonas maltophilia is a critical opportunistic pathogen, yet its long-term epidemiology remains underrepresented in global surveillance frameworks like WHO GLASS. We aimed to analyze its six-year epidemiological trend in a large Polish tertiary hospital. Methods: A retrospective study (2020\u20132025) of 399 non-duplicate isolates was conducted. Identification was performed using MALDI-TOF MS, and susceptibility was analyzed according to EUCAST breakpoints. Antibiotic consumption (DDD\/100 patient-days) was correlated with isolation trends. Results: Wound\/skin (36.8%) and lower respiratory tract (35.8%) samples predominated. A significant rise in respiratory isolates was observed post-2020, coinciding with peak carbapenem consumption in ICU and surgical wards. Ward-level analysis demonstrated that intensive care unit status (\u03b2 = 68.9, 95% CI 46.1\u201391.8, p &lt; 0.001) and carbapenem consumption (\u03b2 = 0.080, 95% CI 0.004\u20130.156, p = 0.041) were independently associated with S. maltophilia isolation burden after adjustment for ward type (adjusted R2 = 0.80). While trimethoprim\u2013sulfamethoxazole remained highly active, levofloxacin susceptibility showed high interannual variability. Conclusions: S. maltophilia is a stable and clinically significant threat in high-intensity hospital environments. Our findings support the inclusion of this pathogen in international AMR monitoring (GLASS) and emphasize strict carbapenem stewardship to curb its emergence.<\/jats:p>","DOI":"10.3390\/jcm15145636","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:54:13Z","timestamp":1784534053000},"page":"5636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shifting Epidemiology of Stenotrophomonas maltophilia: Specimen-, Ward-, and Time-Dependent Patterns in a Tertiary Hospital 2020\u20132025\u2014An Observational Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-8451","authenticated-orcid":false,"given":"Aneta","family":"Guzek","sequence":"first","affiliation":[{"name":"Department of Laboratory Diagnostics, Section of Microbiology, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Olczak-Pie\u0144kowska","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology and Vaccinology, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-2281","authenticated-orcid":false,"given":"Wies\u0142aw","family":"Piechota","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Rybicki","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Konior","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Tropical Medicine, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2101-5053","authenticated-orcid":false,"given":"Katarzyna","family":"Mackiewicz","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Section of Microbiology, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7723-813X","authenticated-orcid":false,"given":"Monika","family":"Kania","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology and Vaccinology, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Warda","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Hospital Infection Control, Military Institute of Medicine\u2013National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1473-3099(09)70083-0","article-title":"Stenotrophomonas maltophilia: An emerging opportunist human pathogen","volume":"9","author":"Looney","year":"2009","journal-title":"Lancet Infect. 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