{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:02:51Z","timestamp":1784696571374,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: The inferior mesenteric vein (IMV) is an important component of the portal venous system; however, normative developmental data during childhood remain limited. This study aimed to evaluate age- and sex-related changes in IMV caliber using contrast-enhanced computed tomography in a pediatric population. Methods: Radiologic images of 200 subjects aged 1\u201320 years were included in the examination. Terminal (IMV1), intermediate (IMV2), and pelvic (IMV3) calibers of the IMV were measured. Ratios of vessel calibers to the transverse diameter of the first lumbar vertebral body (L1TD) were calculated. In addition, the drainage pattern of the IMV was recorded. Results: L1TD, IMV1, IMV2, and IMV3 demonstrated significant age-related changes (p &lt; 0.001). All IMV calibers increased from infancy to the postpubescent period. Among the calculated ratios, IMV1\/L1TD and IMV3\/L1TD demonstrated significant age-related variation (p &lt; 0.05), whereas IMV2\/L1TD remained relatively stable throughout childhood and adolescence (p &gt; 0.05). No significant sex-related differences were observed for most parameters, although IMV3 was significantly greater in males than in females (p = 0.043). The splenic vein was the most common termination site of the IMV (47.5%), followed by the superior mesenteric vein (29.5%) and the splenomesenteric confluence (23.0%). Conclusions: The present study provides normative age-specific values for IMV caliber and IMV-to-L1TD ratios in the pediatric population. These data may facilitate the radiological assessment of IMV-related abnormalities and provide a practical reference for routine computed tomography evaluation of the pediatric mesentericoportal venous system.<\/jats:p>","DOI":"10.3390\/jcm15145643","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:54:13Z","timestamp":1784534053000},"page":"5643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Normative Data on Inferior Mesenteric Vein Caliber in the Pediatric Population"],"prefix":"10.3390","volume":"15","author":[{"given":"Ozan","family":"Okyay","sequence":"first","affiliation":[{"name":"Department of General Surgery, Van Training and Research Hospital, University of Health Sciences, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"Binici","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-196X","authenticated-orcid":false,"given":"F\u0131rat","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-6542","authenticated-orcid":false,"given":"Iklil","family":"Ery\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kartal Dr. Lutfi Kirdar City Hospital, 34865 \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Yan\u00e7","sequence":"additional","affiliation":[{"name":"Department of Radiology, \u015e\u0131rnak State Hospital, 73000 \u015e\u0131rnak, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3516-5561","authenticated-orcid":false,"given":"Veysel","family":"Tahiro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences, \u015e\u0131rnak University, 73000 \u015e\u0131rnak, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Beger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-4779","authenticated-orcid":false,"given":"Mehmet Tolgahan","family":"\u00d6rmeci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Haydarpa\u015fa Numune Training and Research Hospital, 34668 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-077X","authenticated-orcid":false,"given":"\u0130lyas","family":"D\u00fcndar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut Baran","family":"Yerlikaya","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-4455","authenticated-orcid":false,"given":"Ali R\u0131za","family":"Karay\u0131l","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Van Training and Research Hospital, University of Health Sciences, 65090 Van, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-8758","authenticated-orcid":false,"given":"Orhan","family":"Beger","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Gaziantep University, 27410 Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"ref_1","unstructured":"Standring, S. (2016). Gray\u2019s Anatomy: The Anatomical Basis of Clinical Practice, Elsevier. [41st ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.crad.2007.09.001","article-title":"MDCT of inferior mesenteric vein: Normal anatomy and pathology","volume":"63","author":"Akpinar","year":"2008","journal-title":"Clin. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tubbs, R.S., Shoja, M.M., and Loukas, M. (2016). Bergman\u2019s Comprehensive Encyclopedia of Human Anatomic Variation, Wiley. [1st ed.].","DOI":"10.1002\/9781118430309"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"goag044","DOI":"10.1093\/gastro\/goag044","article-title":"Ligation site of the inferior mesenteric vein in laparoscopic radical resection of rectal cancer: A study protocol for a multicenter randomized-controlled trial","volume":"14","author":"Hu","year":"2026","journal-title":"Gastroenterol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1007\/s00464-012-2710-9","article-title":"Role of CT angiography with three-dimensional reconstruction of mesenteric vessels in laparoscopic colorectal resections: A randomized controlled trial","volume":"27","author":"Mari","year":"2013","journal-title":"Surg. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"151743","DOI":"10.1016\/j.aanat.2021.151743","article-title":"Anatomical framework for pre-operative planning of laparoscopic left-sided colorectal surgery: Potential relevance of the distance between the inferior mesenteric artery and inferior mesenteric vein","volume":"237","author":"Billmann","year":"2021","journal-title":"Ann. Anat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00595-021-02292-8","article-title":"Anatomical study of the inferior mesenteric vein using three-dimensional computed tomography angiography in laparoscopy-assisted surgery for left-sided colorectal cancer","volume":"51","author":"Nepal","year":"2021","journal-title":"Surg. Today"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/RCT.0000000000000576","article-title":"Left colonic bleeding secondary to inferior mesenteric vein stenosis","volume":"41","author":"Le","year":"2017","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/codi.13811","article-title":"Assessment of the inferior mesenteric vein diameter as a surrogate marker to evaluate response to neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma","volume":"19","author":"Ivan","year":"2017","journal-title":"Colorectal Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11604-024-01726-w","article-title":"Age-dependent changes in diameters of abdominal visceral arteries in children","volume":"43","author":"Ten","year":"2025","journal-title":"Jpn. J. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00276-024-03385-y","article-title":"Effective diameter of the abdominal aorta in children","volume":"46","author":"Beger","year":"2024","journal-title":"Surg. Radiol. Anat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/ped.13542","article-title":"Normal abdominal aorta diameter in infants, children and adolescents","volume":"60","author":"Akturk","year":"2018","journal-title":"Pediatr. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1007\/s44411-025-00351-x","article-title":"Reference values for normal main portal vein diameter in subjects aged 1\u201380 years","volume":"126","author":"Binici","year":"2025","journal-title":"Bratisl. Med. J."},{"key":"ref_14","unstructured":"Goodway, J.D., Ozmun, J.C., and Gallahue, D.L. (2019). Understanding Motor Development: Infants, Children, Adolescents, Adults, Jones & Bartlett Learning. [1st ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cult.2007.06.001","article-title":"Sonographic evaluation of the abdominal aorta","volume":"2","author":"Bhatt","year":"2007","journal-title":"Ultrasound Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.21037\/cdt.2017.09.14","article-title":"Syndromes with aortic involvement: Pictorial review","volume":"8","author":"Zucker","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1007\/s00261-024-04755-1","article-title":"Assessment of Normal Portal Vein Diameter in Children and Adolescents on Abdominal Contrast-Enhanced CT","volume":"50","author":"Chen","year":"2025","journal-title":"Abdom. Radiol."},{"key":"ref_18","first-page":"1085","article-title":"Surface area in children: A simple formula","volume":"46","author":"Furqan","year":"2009","journal-title":"Indian. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1148\/radiol.2283020095","article-title":"Determination of height, weight, body mass index, and body surface area with a single abdominal CT image","volume":"228","author":"Geraghty","year":"2003","journal-title":"Radiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00276-009-0525-8","article-title":"Diameters of normal thoracic vascular structures in pediatric patients","volume":"31","author":"Akay","year":"2009","journal-title":"Surg. Radiol. Anat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0971-9261.109362","article-title":"Isolated inferior mesenteric portal hypertension with giant inferior mesenteric vein and anomalous inferior mesenteric vein insertion","volume":"18","author":"Prasad","year":"2013","journal-title":"J. Indian. Assoc. Pediatr. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101278","DOI":"10.1016\/j.jceh.2023.08.014","article-title":"Rectal bleed in a child with Abernethy malformation\u2014Endovascular management","volume":"14","author":"Khan","year":"2024","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100160","DOI":"10.1016\/j.avsurg.2023.100160","article-title":"A proximal inferior mesenteric vein to left renal vein shunt as a treatment of congenital absence of right portal vein","volume":"3","author":"Zhang","year":"2023","journal-title":"Ann. Vasc. Surg. Brief. Rep. Innov."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0002-9610(99)00127-0","article-title":"Surgical technique for inferior mesenteric vein to renal vein shunt in portal hypertension","volume":"178","author":"Deshmukh","year":"1999","journal-title":"Am. J. Surg."},{"key":"ref_25","first-page":"1161","article-title":"Morphology of the inferior mesenteric vein in cadavers","volume":"8","author":"Le","year":"2026","journal-title":"J. Med. Pharm. Chem. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.2214\/ajr.168.5.9129413","article-title":"Anatomic variants of mesenteric veins: Depiction with helical CT venography","volume":"168","author":"Graf","year":"1997","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_27","first-page":"1123","article-title":"Depiction of variants of the portal confluence venous system using multidetector row CT: Analysis of 916 cases","volume":"183","author":"Krumm","year":"2011","journal-title":"R\u00f6Fo"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/ases.12657","article-title":"Evaluation of the venous drainage pattern of the splenic flexure by preoperative three-dimensional computed tomography","volume":"12","author":"Arimoto","year":"2019","journal-title":"Asian J. Endosc. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.28982\/josam.7980","article-title":"Evaluation of inferior mesenteric vein drainage patterns in the Turkish population: A multidetector computed tomography study","volume":"7","year":"2023","journal-title":"J. Surg. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5643\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:17:25Z","timestamp":1784693845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":29,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145643"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145643","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]}}}