{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:23:26Z","timestamp":1785425006871,"version":"3.56.0"},"reference-count":19,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030943","name":"Chosun University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030943","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/0131gn249","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Rectal gastrointestinal stromal tumors (GISTs) near the dentate line (DL) present significant surgical challenges due to anatomical constraints and difficulty preserving anal function. Endoscopic intermuscular dissection (EID) is a viable alternative in these cases. Methods: We retrospectively reviewed the medical records of patients who underwent EIDs for rectal GISTs near the DL between January 2015 and December 2023. The primary outcomes assessed were procedural efficacy\u2014measured by en bloc and complete resection rates\u2014and safety, evaluated regarding delayed bleeding, perforation, and tumor recurrence. Results: In total, 10 patients underwent rectal GIST EIDs. The mean tumor size, procedure time, and resection speed were 25.70 \u00b1 14.09 mm, 81.30 \u00b1 46.20 min, and 16.91 \u00b1 9.94 mm2\/min, respectively. The en bloc and complete resection rates were 100% and 70%, respectively. Compared with endoscopic submucosal dissection (ESD) for rectal epithelial lesions, there were no significant differences in procedure times (81.30 \u00b1 46.20 min vs. 76.50 \u00b1 32.42 min, p = 0.758) or complete resection rates (70% vs. 95%, p = 0.095). Regarding safety, delayed bleeding (10% vs. 10%, p = 1.000) and perforation (10% vs. 0%, p = 0.333) rates did not differ significantly between the two groups. During a median 36-month follow-up, one recurrence occurred in a patient with a high-risk GIST. Conclusions: EID for rectal GISTs near the DL appears to be a feasible and potentially safe treatment option in carefully selected patients. It may represent a less invasive alternative to surgery, particularly when preservation of anal function is a priority. Nevertheless, validation in larger prospective studies is required.<\/jats:p>","DOI":"10.3390\/jcm15145712","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:35:52Z","timestamp":1784630152000},"page":"5712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness and Safety of Endoscopic Intermuscular Dissection for the Treatment of Rectal Gastrointestinal Stromal Tumors: A Pilot Feasibility Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-941X","authenticated-orcid":false,"given":"Seong-Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Chosun University College of Medicine, 309 Pilmun-daero, Dong-gu, Jeonnam-Gwangju Special Metropolitan City 61452, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chosun University College of Medicine, 309 Pilmun-daero, Dong-gu, Jeonnam-Gwangju Special Metropolitan City 61452, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hyeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chosun University College of Medicine, 309 Pilmun-daero, Dong-gu, Jeonnam-Gwangju Special Metropolitan City 61452, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-9646","authenticated-orcid":false,"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chosun University College of Medicine, 309 Pilmun-daero, Dong-gu, Jeonnam-Gwangju Special Metropolitan City 61452, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","unstructured":"NCCN (2024). 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