{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:06:56Z","timestamp":1784714816939,"version":"3.55.0"},"reference-count":22,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: To assess the refractive and visual outcomes after implantation of an isofocal optic-design intraocular lens (IOL) with double C-loop haptics following cataract surgery in eyes with primary open-angle glaucoma (POAG). Methods: This was a prospective, open-label, interventional exploratory study that considered POAG eyes undergoing cataract surgery with implantation of the Isopure Serenity (Beaver-Visitec International, Inc. [BVI], Waltham, MA, USA) IOL. Primary outcomes measured included manifest refraction, monocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA) and distance-corrected intermediate visual acuity (DCIVA) at 80 and 66 cm, uncorrected near visual acuity (UNVA), and distance-corrected near visual acuity (DCNVA) at 40 cm, and photopic binocular defocus curve were evaluated 3 months after surgery. Results: In total, 22 eyes of 11 patients (nine women, mean age of 68.3 \u00b1 8.3 years) with POAG were enrolled and completed the clinical study. The study found that 100% of the eyes were within \u00b10.50 D and 86.36% of the eyes showed a postoperative refractive cylinder \u2264 0.25 D. The mean spherical equivalent and refractive cylinder were \u22120.06 \u00b1 0.30 D and \u22120.13 \u00b1 0.33 D, respectively. It was also shown that 86.36% and 100% of the eyes had 20\/20 or better UDVA and CDVA, respectively. Furthermore, 95.45% and 77.27% of eyes presented a monocular DCIVA value of \u226520\/32 at 80 and 66 cm, respectively, and 68.18% of eyes presented a monocular DCNVA value of \u226520\/40. The mean monocular CDVA, DCIVA at 80 cm, DCIVA at 66 cm, and DCNVA were \u22120.09 \u00b1 0.04, 0.12 \u00b1 0.07, 0.21 \u00b1 0.07 and 0.32 \u00b1 0.07 logMAR, respectively. The binocular defocus curve showed good visual acuity at distance and intermediate vision. Conclusions: The isofocal Isopure Serenity IOL can be implanted in eyes with POAG after cataract surgery, achieving a satisfactory visual performance. Our results suggest that this IOL model is a viable option for selected patients with controlled early\/moderate POAG and without central visual field involvement diagnosed with cataracts.<\/jats:p>","DOI":"10.3390\/jcm15145730","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:39Z","timestamp":1784712039000},"page":"5730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Clinical Outcomes of an Isofocal Optic-Design Intraocular Lens with Double C-Loop Haptics in Eyes with Glaucoma"],"prefix":"10.3390","volume":"15","author":[{"given":"Takayuki","family":"Akahoshi","sequence":"first","affiliation":[{"name":"Department of Cataract and Refractive Surgery, Nihonbashi Cataract-Clinic, Tokyo 103-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1016\/j.ophtha.2020.08.025","article-title":"Matching the Patient to the Intraocular Lens: Preoperative Considerations to Optimize Surgical Outcomes","volume":"128","author":"Yeu","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Peterson, C.L., Wong, T.T., and Perera, S. (2025). Editorial: Insights in glaucoma: 2023. Front. Ophthalmol., 4.","DOI":"10.3389\/fopht.2024.1519088"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104431","DOI":"10.1016\/j.jfo.2025.104431","article-title":"Utilisation des implants premium chez les patients glaucomateux: Conseils de la Soci\u00e9t\u00e9 fran\u00e7aise du glaucome (SFG) et de la Soci\u00e9t\u00e9 de l\u2019association fran\u00e7aise des implants intra-oculaires et de chirurgie r\u00e9fractive (SAFIR) [Premium IOL\u2019s in glaucoma patients: Guidelines from the French Glaucoma Society (SFG) and the Society of the French Intraocular Lens and Refractive Surgery Association]","volume":"48","author":"Blumen","year":"2025","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2147\/OPTH.S411561","article-title":"Visual Outcomes, Spectacle Independence, and Patient-Reported Satisfaction of the Vivity Extended Range of Vision Intraocular Lens in Patients with Early Glaucoma: An Observational Comparative Study","volume":"17","author":"Kerr","year":"2023","journal-title":"Clin. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Nam, J.W., Lee, J.H., Zhang, H., Sung, M.S., and Park, S.W. (2023). Comparison of the Visual Outcomes of Enhanced and Standard Monofocal Intraocular Lens Implantations in Eyes with Early Glaucoma. J. Clin. Med., 12.","DOI":"10.20944\/preprints202307.1922.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2147\/OPTH.S404369","article-title":"Clinical Outcomes of a Non-Diffractive Extended Depth-of-Focus IOL in Eyes with Mild Glaucoma","volume":"17","author":"Ferguson","year":"2023","journal-title":"Clin. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101792","DOI":"10.1016\/j.ajoc.2022.101792","article-title":"Implantation of diffractive extended depth-of-focus intraocular lenses in normal tension glaucoma eyes: A case series","volume":"29","author":"Ota","year":"2023","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1007\/s40123-023-00801-1","article-title":"Visual Function after Implantation of Diffractive Extended Depth-of-Focus Intraocular Lenses in Eyes with Primary Open-Angle Glaucoma","volume":"12","author":"Ota","year":"2023","journal-title":"Ophthalmol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s10792-024-03350-z","article-title":"Effect of enhanced monofocal intraocular lenses on glaucoma patients\u2019 foveal threshold","volume":"44","author":"Tojo","year":"2024","journal-title":"Int. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1007\/s40123-024-01035-5","article-title":"Influence of Visual Field on Visual Acuity and Contrast Sensitivity in Open-Angle Glaucoma Eyes with Monofocal and Extended Depth-of-Focus Intraocular Lenses","volume":"13","author":"Ota","year":"2024","journal-title":"Ophthalmol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chung, H.S., Jang, J.H., Lee, H., Kim, J.Y., and Tchah, H. (2024). Clinical outcomes after implantation of a new monofocal intraocular lens with enhanced intermediate function in patients with preperimetric glaucoma. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1260298"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s10792-024-03361-w","article-title":"Clinical outcomes of an extended depth-of-focus intraocular lens in patients with glaucoma","volume":"44","author":"Dessouky","year":"2024","journal-title":"Int. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.18240\/ijo.2025.01.09","article-title":"Outcomes of a non-diffractive extended depth of focus intraocular lens in patients with well-controlled glaucoma and ocular hypertension","volume":"18","author":"Liu","year":"2025","journal-title":"Int. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s40123-025-01124-z","article-title":"Evaluation of Visual, Refractive, and Functional Outcomes after Implantation of an Extended Depth of Focus Intraocular Lens in Patients with Stable and Mild Glaucoma","volume":"14","author":"Urcola","year":"2025","journal-title":"Ophthalmol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.2147\/OPTH.S535100","article-title":"Visual and Refractive Outcomes After Implantation of an Isofocal Optic-Design Intraocular Lens with Double C-Loop Haptics in Japanese Eyes","volume":"19","author":"Akahoshi","year":"2025","journal-title":"Clin. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.2147\/OPTH.S542276","article-title":"Clinical Outcomes of a Multicenter Study Following Implantation of an Isofocal Optic IOL with Double C-Loop Haptics","volume":"19","author":"Daya","year":"2025","journal-title":"Clin. Ophthalmol."},{"key":"ref_17","unstructured":"Elander, R. (1998). Phaco Prechop: Manual Nucleofracture Prior to Phacoemulsification. Operative Techniques in Cataract and Refractive Surgery, W.B. Saunders Company."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2147\/OPTH.S464432","article-title":"Refractive and Visual Outcomes Using a Trifocal, Diffractive, Hydrophobic Intraocular Lens in Japanese Eyes","volume":"18","author":"Akahoshi","year":"2024","journal-title":"Clin. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.2147\/OPTH.S471846","article-title":"Hydrophobic Trifocal Toric Intraocular Lens Outcomes in Japanese Eyes After Cataract Surgery","volume":"18","author":"Akahoshi","year":"2024","journal-title":"Clin. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.2147\/OPTH.S478292","article-title":"Three Patient-Reported Outcomes Questionnaires in Japanese Patients Undergoing Cataract Surgery with Trifocal IOL Implantation","volume":"18","author":"Akahoshi","year":"2024","journal-title":"Clin. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jcrs.2018.07.027","article-title":"Pursuing perfection in intraocular lens calculations: IV. Rethinking astigmatism analysis for intraocular lens-based surgery: Suggested terminology, analysis, and standards for outcome reports","volume":"44","author":"Abulafia","year":"2018","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3928\/1081597X-20170302-01","article-title":"Standard for Reporting Refractive Outcomes of Intraocular Lens-Based Refractive Surgery","volume":"33","author":"Reinstein","year":"2017","journal-title":"J. Refract. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5730\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:57:16Z","timestamp":1784714236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":22,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145730"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145730","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}