{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:06:59Z","timestamp":1784714819015,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Placental abruption has a high risk of recurrence, but the timing of recurrence relative to the previous episode remains unclear. This study described the gestational-age distribution of recurrent placental abruption and compared recurrent with first-time placental abruption in multiparous women. Methods: This retrospective multicenter descriptive study included 239 hospital-managed cases of placental abruption at nine perinatal centers in northern Japan from 2003 to 2024. Clinical characteristics and outcomes were compared between multiparous women with recurrent placental abruption (n = 10) and those with first-time placental abruption and no prior history of placental abruption (n = 134). Recurrence timing was assessed descriptively by comparing gestational age at onset between previous and current episodes. Results: Among 239 cases, 10 women had recurrent placental abruption. Maternal age was higher in the recurrent group, whereas BMI, smoking, assisted reproductive technology, and hypertensive disorders of pregnancy were similar between groups. Most clinical features and maternal and neonatal outcomes did not differ significantly, although birth weight was higher in the recurrent group. Among 11 recurrent events, 6 occurred within \u00b11 week (54.5%; exact 95% CI, 23.4\u201383.3%) and 8 within \u00b12 weeks (72.7%; exact 95% CI, 39.0\u201394.0%) of the previous gestational age. Available placental pathology in recurrent cases was reviewed descriptively only and was not interpreted as evidence of an association between maternal vascular malperfusion and recurrence. Conclusions: In this small exploratory cohort, recurrent placental abruption tended to occur within approximately \u00b11 to \u00b12 weeks of the gestational age of the previous episode, with 6 of 11 recurrent events occurring within \u00b11 week and 8 of 11 occurring within \u00b12 weeks. These exploratory findings may assist clinicians when individualizing surveillance strategies but should not be interpreted as supporting a specific surveillance protocol; confirmation in larger datasets is required.<\/jats:p>","DOI":"10.3390\/jcm15145734","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:39Z","timestamp":1784712039000},"page":"5734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational-Age Clustering of Recurrent Placental Abruption: A Multicenter Retrospective Descriptive Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Mako","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-1159","authenticated-orcid":false,"given":"Kaori","family":"Iino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Perinatal Maternal and Child Center, Aomori Prefectural Central Hospital, Aomori 030-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Aomori City Hospital, Aomori 030-0821, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Odate Municipal General Hospital, Odate 017-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hirosaki General Medical Center, Hirosaki 036-8545, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisa","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mutsu General Hospital, Mutsu 035-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sota","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hachinohe City Hospital, Hachinohe 031-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tsugaru General Hospital, Goshogawara 037-0074, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Misawa City Hospital, Misawa 033-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4854-1553","authenticated-orcid":false,"given":"Asami","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-512X","authenticated-orcid":false,"given":"Yoshihito","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1313","DOI":"10.1016\/j.ajog.2022.06.059","article-title":"Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management","volume":"228","author":"Brandt","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/01.AOG.0000239439.04364.9a","article-title":"Placental abruption","volume":"108","author":"Oyelese","year":"2006","journal-title":"Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0412.2010.01030.x","article-title":"Placental abruption: Epidemiology, risk factors and consequences","volume":"90","author":"Tikkanen","year":"2011","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chen, D., Gao, X., Yang, T., Xin, X., Wang, G., Wang, H., He, R., and Liu, M. (2025). Independent risk factors for placental abruption: A systematic review and meta-analysis. BMC Pregnancy Childbirth, 25.","DOI":"10.1186\/s12884-025-07482-7"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"B\u0105czkowska, M., Kosi\u0144ska-Kaczy\u0144ska, K., Zgliczy\u0144ska, M., Brawura-Biskupski-Samaha, R., Rebizant, B., and Ciebiera, M. (2022). Epidemiology, risk factors, and perinatal outcomes of placental abruption\u2014Detailed annual data and clinical perspectives from Polish tertiary center. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19095148"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Anderson, E., Raja, E.A., Shetty, A., Gissler, M., Gatt, M., and Bhattacharya, S. (2020). Changing risk factors for placental abruption: A case crossover study using routinely collected data from Finland, Malta and Aberdeen. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233641"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104279","DOI":"10.1016\/j.jri.2024.104279","article-title":"Can inflammatory biomarkers based on first trimester complete blood count parameters predict placental abruption? A case-control study","volume":"164","author":"Ozkan","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Su, L., Zhang, J., and Wu, H. (2025). Interpretable machine learning for predicting placental abruption in early-onset preeclampsia: Model development and evaluation. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1731693"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"114801","DOI":"10.1016\/j.ejogrb.2025.114801","article-title":"Familial risk of placental abruption","volume":"316","author":"Dalton","year":"2026","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"573.e1","DOI":"10.1016\/j.ajog.2015.06.019","article-title":"Incidence and recurrence rate of placental abruption: A longitudinal linked national cohort study in the Netherlands","volume":"213","author":"Ruiter","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10140-018-1638-3","article-title":"Placental abruption and hemorrhage\u2014Review of imaging appearance","volume":"26","author":"Fadl","year":"2019","journal-title":"Emerg. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1034\/j.1600-0412.2001.080008708.x","article-title":"Women with a history of placental abruption: When in a subsequent pregnancy should special surveillance for a recurrent placental abruption be initiated?","volume":"80","author":"Rasmussen","year":"2001","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_13","first-page":"CD003247","article-title":"Interventions for treating placental abruption","volume":"2003","author":"Neilson","year":"2003","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1111\/aogs.70063","article-title":"Ascending infection is the leading cause of antepartum hemorrhage: A case-control study","volume":"104","author":"Gromadzyn","year":"2025","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kahraman, N.C., Obut, M., Arat, O., Gucel, F., \u00c7aglar, A.T., and \u00dcst\u00fcn, Y.E. (2025). Association of maternal calprotectin plasma levels with abruption placenta. BMC Pregnancy Childbirth, 25.","DOI":"10.1186\/s12884-025-07356-y"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/j.semperi.2014.03.001","article-title":"Ischemic placental disease: A unifying concept for preeclampsia, intrauterine growth restriction, and placental abruption","volume":"38","author":"Ananth","year":"2014","journal-title":"Semin. Perinatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/apm.12833","article-title":"Maternal vascular malperfusion of the placental bed","volume":"126","author":"Ernst","year":"2018","journal-title":"APMIS"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gusella, A., Martignoni, G., and Giacometti, C. (2024). Behind the curtain of abnormal placentation in pre-eclampsia: From molecular mechanisms to histological hallmarks. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147886"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/00016340500449915","article-title":"Clinical presentation and risk factors of placental abruption","volume":"85","author":"Tikkanen","year":"2006","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e00715","DOI":"10.1016\/j.crwh.2025.e00715","article-title":"Mode of delivery in placental abruption: A case report on difficulty in distinguishing between uterine rupture and placental abruption due to clinical features that overlap","volume":"46","author":"Darko","year":"2025","journal-title":"Case Rep. Women\u2019s Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4594136","DOI":"10.1155\/2022\/4594136","article-title":"Adverse perinatal and maternal outcomes and associated factors among women with antepartum hemorrhage in Jimma University Medical Center, Southwest Ethiopia, 2020","volume":"2022","author":"Gelan","year":"2022","journal-title":"Obstet. Gynecol. Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5734\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:57:52Z","timestamp":1784714272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/14\/5734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":21,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["jcm15145734"],"URL":"https:\/\/doi.org\/10.3390\/jcm15145734","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}