{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:07:34Z","timestamp":1784830054290,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Women-specific short-term body mass index and metabolic changes after Roux-en-Y gastric bypass remain incompletely characterized. This retrospective cohort study evaluated 12-month changes in body mass index, glycemic markers, and lipid profile after Roux-en-Y gastric bypass in women with severe obesity treated at a public bariatric reference center in Brazil. Methods: Women who underwent Roux-en-Y gastric bypass between September 2017 and January 2020 were assessed preoperatively and at 30 days, 3 months, 6 months, and 12 months postoperatively. Longitudinal changes were analyzed using linear mixed-effects models. Results: Of 168 women who underwent bariatric surgery, 150 had complete 12-month follow-up data. Mean age was 43.6 \u00b1 9.8 years and mean preoperative body mass index was 45.4 \u00b1 5.4 kg\/m2. Body mass index decreased progressively from 45.5 kg\/m2 at baseline to 31.5 kg\/m2 at 12 months. Fasting plasma glucose and HbA1c declined significantly within the first postoperative month and remained improved. Total cholesterol decreased at 30 days, whereas low-density lipoprotein (LDL) cholesterol and triglycerides decreased by 6 months. Among baseline users, 86% discontinued antihyperglycemic therapy, 87% lipid-lowering therapy, and 72% antihypertensive therapy; these exploratory medication-discontinuation outcomes should not be interpreted as validated remission of diabetes, dyslipidemia, or hypertension. Conclusions: Roux-en-Y gastric bypass was associated with substantial short-term body mass index reduction and improved cardiometabolic markers among women.<\/jats:p>","DOI":"10.3390\/jcm15155764","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:13:17Z","timestamp":1784826797000},"page":"5764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twelve-Month BMI and Metabolic Changes After Roux-en-Y Gastric Bypass in Women with Severe Obesity"],"prefix":"10.3390","volume":"15","author":[{"given":"Augusto Cardoso","family":"Sgarioni","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"},{"name":"Department of Surgery, General Hospital of Caxias do Sul, Caxias do Sul 95070-561, Brazil"},{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-7634","authenticated-orcid":false,"given":"Giovani Schulte","family":"Farina","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulio Slongo","family":"Bressan","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Prigol","family":"Dalfovo","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1698-076X","authenticated-orcid":false,"given":"Gabriel Michelin","family":"De Carli","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Jo\u00e3o Prataviera","family":"Giovanardi","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Hospital of Caxias do Sul, Caxias do Sul 95070-561, Brazil"},{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Schumacher","family":"Giovanardi","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Hospital of Caxias do Sul, Caxias do Sul 95070-561, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano da Silva","family":"Selistre","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"},{"name":"School of Medicine, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria","family":"Rahmi Garcia","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, University of Caxias do Sul, Caxias do Sul 95070-560, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mce.2009.07.008","article-title":"The effect of obesity on health outcomes","volume":"316","author":"Dixon","year":"2010","journal-title":"Mol. 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