{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:24:17Z","timestamp":1785435857705,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["101073533"],"award-info":[{"award-number":["101073533"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"award":["101073533"],"award-info":[{"award-number":["101073533"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Active Charcot neuro-osteoarthropathy (CNO) requires prolonged offloading, yet no reliable markers exist to predict time to remission at diagnosis. This study examined whether plantar pressure and radiographic deformity at diagnosis are associated with time to remission, and whether these measures provided independent and complementary prognostic value. Methods: This retrospective cohort study included 20 adults with active CNO. Barefoot peak plantar pressure and five radiographic angles from weight-bearing lateral radiographs were assessed at diagnosis. Associations with time to remission were examined using Spearman correlation and receiver operating characteristic (ROC) analysis. Results: Median time to remission was 132 days (interquartile range [IQR] 102 to 155). Medial midfoot plantar pressure showed a moderate non-significant association with time to remission (\u03c1 0.42, p = 0.064, area under the curve (AUC) 0.71). Of three radiographic angles with significant associations after false discovery rate correction, talar declination showed the strongest association with time to remission (\u03c1 0.76, p &lt; 0.001) and demonstrated good discriminative performance for delayed remission (AUC: 0.89, 95% CI: 0.74 to 1.00). Meary\u2019s angle performed comparably (AUC 0.86, 95% CI 0.69 to 1.00), consistent with high collinearity between measures (\u03c1 = \u22120.94). Adding plantar pressure to talar declination did not improve discriminative performance (combined AUC 0.89, DeLong p = 1.00). Conclusions: In this exploratory cohort, talar declination and Meary\u2019s angle demonstrated good discriminative performance for delayed remission. Plantar pressure showed a positive association with time to remission that did not reach statistical significance and did not improve discriminative performance when combined with radiographic assessment. Radiographic measurement at diagnosis, specifically talar declination or Meary\u2019s angle, may support prognostic discussions with patients and inform decisions around offloading duration, pending prospective validation.<\/jats:p>","DOI":"10.3390\/jcm15155828","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:47:41Z","timestamp":1785145661000},"page":"5828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plantar Pressure and Radiographic Deformity at Diagnosis of Active Charcot Neuro-Osteoarthropathy as Potential Prognostic Markers for Time to Remission"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7416-956X","authenticated-orcid":false,"given":"Victoria E. L.","family":"Milbourn","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"},{"name":"Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-7096","authenticated-orcid":false,"given":"Kerensa M.","family":"Beekman","sequence":"additional","affiliation":[{"name":"Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Nieuwdorp","sequence":"additional","affiliation":[{"name":"Department of Internal and Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"},{"name":"Diabeter (Center Amsterdam), 1066 EC Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa E.","family":"Busch-Westbroek","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-9163","authenticated-orcid":false,"given":"Sicco A.","family":"Bus","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"},{"name":"Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-6565","authenticated-orcid":false,"given":"Nina L.","family":"Petrova","sequence":"additional","affiliation":[{"name":"Mike Edmonds Foot Unit, King\u2019s College Hospital National Health Service Foundation Trust, London SE5 9RS, UK"},{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-6046","authenticated-orcid":false,"given":"Jaap J.","family":"Van Netten","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"},{"name":"Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/dme.13679","article-title":"Prevalence of active Charcot disease in the East Midlands of England","volume":"35","author":"Metcalf","year":"2018","journal-title":"Diabet. 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