{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:02:52Z","timestamp":1785315772010,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for the Top-Notch Youth Talent Cultivation Project of the Independent Design Project of the National Clinical Research Center for Child Health","award":["Q21A0006"],"award-info":[{"award-number":["Q21A0006"]}]},{"name":"Starting Research Foundation of The Children\u2019s Hospital, Zhejiang University School of Medicine","award":["481"],"award-info":[{"award-number":["481"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background:\u00a0Acinetobacter baumannii and Klebsiella pneumoniae are important causes of hospital-acquired infections in pediatric patients, but comparative data on their clinical manifestations and inflammatory biomarkers remain limited. Methods: We retrospectively analyzed 55 children with single-positive blood cultures for A. baumannii (n = 20) or K. pneumoniae (n = 35), together with 30 healthy controls. Results: CRP, IL-6, and IL-10 were higher in infected children than in healthy controls. Logistic regression identified CRP and the IL-6\/IL-10 ratio as exploratory correlates of infection. In ROC analyses distinguishing infected children from healthy controls, IL-6 showed the highest AUC, followed by IL-10 and CRP. In pathogen-level analyses, the IL-6\/IL-10 ratio and lipase showed exploratory discriminatory signals. Conclusions: In this small retrospective case\u2013control cohort, CRP, IL-6, and IL-10 were associated with microbiologically confirmed infection. Lipase may represent a potential biomarker for differentiating A. baumannii from K. pneumoniae infection, but its clinical utility requires prospective validation in larger multicenter cohorts using clinically relevant inpatient control groups.<\/jats:p>","DOI":"10.3390\/jcm15155914","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:16:52Z","timestamp":1785313012000},"page":"5914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Clinical Indicators in Pediatric Patients with Acinetobacter baumannii and Klebsiella pneumoniae Infections"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2185-2122","authenticated-orcid":false,"given":"Yiyao","family":"Bao","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Dai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-5849","authenticated-orcid":false,"given":"Chao","family":"Tang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","first-page":"893","article-title":"Acinetobacter baumannii bloodstream infections in hematopoietic stem cell transplant recipients: A worldwide systematic review","volume":"22","author":"Balali","year":"2024","journal-title":"Exp. 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