{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:47:26Z","timestamp":1785833246158,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during benidipine therapy remains uncertain. This study evaluated changes in BP and patient-reported angina-related health status in a large real-world cohort. Methods: This prospective, multicenter, observational cohort study included 1659 patients with hypertension and\/or chronic coronary syndrome who underwent baseline clinical assessment before initiation of benidipine therapy and were reassessed after 3 months. Changes in systolic and diastolic BP and Seattle Angina Questionnaire-7 (SAQ-7) scores were evaluated. Multivariable linear regression analyses were performed to identify predictors of BP reduction and symptomatic improvement. A propensity score-matched analysis according to coronary artery disease (CAD) status was conducted to further explore differences in treatment response. Results: The mean age was 62.2 \u00b1 12.2 years, and 54.0% of participants were women. Systolic BP decreased by 13.8 mmHg and diastolic BP by 6.7 mmHg (both p &lt; 0.001). Mean SAQ-7 score increased by 8.1 points (p &lt; 0.001), exceeding the established threshold for clinically meaningful improvement. Baseline SAQ-7 score showed the strongest association with change in SAQ-7, whereas baseline systolic BP was the strongest predictor of BP reduction. The correlation between changes in systolic BP and SAQ-7 was weak (r = 0.058, p = 0.023). In the propensity score-matched cohort (n = 732), BP reduction was similar regardless of CAD status, whereas improvement in SAQ-7 was greater in patients without obstructive CAD. Conclusions: In this multicenter real-world cohort, benidipine therapy was associated with significant BP reduction and clinically meaningful improvement in angina-related health status over 3 months. Symptomatic improvement showed only a weak association with BP reduction. These findings should be interpreted within the limitations of an observational study and warrant confirmation in controlled comparative studies.<\/jats:p>","DOI":"10.3390\/jcm15156047","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:02:19Z","timestamp":1785830539000},"page":"6047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-3651","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"\u00dclgen Kunak","sequence":"first","affiliation":[{"name":"Department of Cardiology, Antalya Training and Research Hospital, University of Health Sciences, Antalya 07100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-2037","authenticated-orcid":false,"given":"Tolga","family":"Kunak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Akdeniz University, Antalya 07100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-5137","authenticated-orcid":false,"given":"Ertan","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Giresun Training and Research Hospital, Giresun 28100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-7099","authenticated-orcid":false,"given":"\u00dcmit Ya\u015far","family":"Sinan","sequence":"additional","affiliation":[{"name":"Department of Preventive and Epidemiologic Cardiology, Cerrahpasa Cardiology Instutite, Istanbul University, \u0130stanbul 34452, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-7345","authenticated-orcid":false,"given":"Ali Nizami","family":"Elmas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Menderes State Hospital, \u0130zmir 35471, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-2751","authenticated-orcid":false,"given":"Umut","family":"Uyan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u00d6demi\u015f State Hospital, \u0130zmir 35750, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkay","family":"Ekici","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Dr. R\u0131dvan Ege Hospital, Ufuk University, Ankara 06836, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-2900","authenticated-orcid":false,"given":"Onur","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tarsus State Hospital, Mersin 33440, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baran","family":"Ar\u0131k","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Torbal\u0131 State Hospital, \u0130zmir 35860, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-0055","authenticated-orcid":false,"given":"K\u00fcbra","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Eski\u015fehir City Hospital, Eski\u015fehir 26080, 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