{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:14:03Z","timestamp":1786115643904,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014677","name":"Universitatea de Medicin\u0103, Farmacie, \u0218tiin\u021be \u0219i Tehnologie \u201eGeorge Emil Palade\u201d din T\u00e2rgu Mure\u0219","doi-asserted-by":"crossref","award":["171\/6\/09.01.2024"],"award-info":[{"award-number":["171\/6\/09.01.2024"]}],"id":[{"id":"10.13039\/501100014677","id-type":"DOI","asserted-by":"crossref"}]},{"award":["171\/6\/09.01.2024"],"award-info":[{"award-number":["171\/6\/09.01.2024"]}],"id":[{"id":"https:\/\/ror.org\/03gwbzf29","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Perinatal oxidative and nitrosative stress may contribute to maternal\u2013neonatal adaptation during delivery. This pilot study evaluated pathway-specific oxidative and nitrosative stress markers from blood samples in paired mother\u2013newborn dyads and explored their associations with delivery-related variables, maternal smoking habits and neonatal clinical state. Methods: The study included 74 mother\u2013newborn dyads, yielding 148 paired maternal and neonatal investigations. Biomarkers included plasma nitrite, nitrate, malondialdehyde, and reduced and oxidized glutathione. Composite pathway-specific indices were calculated: an Oxidative Stress Index (OSI) and a Nitrosative Stress Index (NSI). Results: Paired testing showed that OSI was significantly higher in the maternal compartment compared to the neonatal compartment (p &lt; 0.001), while NSI showed no significant difference (p = 0.594). Maternal and neonatal indices showed positive monotonic correlations (OSI Spearman\u2019s rho = 0.608, p &lt; 0.001; NSI Spearman\u2019s rho = 0.275, p = 0.018). Following false discovery-rate correction (FDR) across the exploratory inferential analysis, no raw or composite biomarkers showed statistically significant differences. Conclusions: This study indicates that while maternal and neonatal oxidative indices are monotonically correlated, their absolute concentrations shift significantly across compartments, highlighting the need to treat these indices as strictly exploratory, hypothesis-generating metrics.<\/jats:p>","DOI":"10.3390\/jcm15156061","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:15:22Z","timestamp":1785834922000},"page":"6061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomarkers of Maternal and Neonatal Oxidative and Nitrosative Stress During Delivery: An Exploratory Pilot Study on Maternal\u2013Neonatal Adaptation to Stress"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-5987","authenticated-orcid":false,"given":"Zsuzs\u00e1nna","family":"Simon-Szab\u00f3","sequence":"first","affiliation":[{"name":"Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Neonatology, Mure\u0219 County Clinical Hospital, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-7947","authenticated-orcid":false,"given":"S\u00e1ndor","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Department of Transfusion Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Nemes-Nagy","sequence":"additional","affiliation":[{"name":"Chemistry and Medical Biochemistry Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Central Laboratory, Emergency Clinical County Hospital of T\u00e2rgu Mure\u0219, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8319-8134","authenticated-orcid":false,"given":"L\u00f3r\u00e1nd","family":"D\u00e9nes","sequence":"additional","affiliation":[{"name":"Anatomy and Embryology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Laboratory of Radiology and Medical Imaging, Mure\u0219 County Clinical Hospital, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea Dumitru","family":"Croitoru","sequence":"additional","affiliation":[{"name":"Toxicology and Biopharmacy Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-6263","authenticated-orcid":false,"given":"Margit","family":"Solym\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Department of Transfusion Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-4639","authenticated-orcid":false,"given":"Zsuzsanna","family":"Faust","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Department of Transfusion Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-5433","authenticated-orcid":false,"given":"Manuela","family":"Cucerea","sequence":"additional","affiliation":[{"name":"Neonatology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540136 T\u00e2rgu Mure\u0219, Romania"},{"name":"Neonatology Clinic, Emergency Clinical County Hospital of T\u00e2rgu Mure\u0219, 540136 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"F\u00e1rr","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3167-5497","authenticated-orcid":false,"given":"Hajnal","family":"Finta","sequence":"additional","affiliation":[{"name":"Department of Public Health and Health Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Medical Evaluation and Statistics, Emergency Clinical County Hospital of T\u00e2rgu Mure\u0219, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-9579","authenticated-orcid":false,"given":"Erzs\u00e9bet","family":"M\u00e1jai","sequence":"additional","affiliation":[{"name":"Toxicology and Biopharmacy Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajog.2019.07.032","article-title":"The Physiology of Intrapartum Fetal Compromise at Term","volume":"222","author":"Turner","year":"2020","journal-title":"Am. 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