{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:25:15Z","timestamp":1787217915026,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Acute mesenteric ischemia (AMI) resembles non-vascular intestinal ischemia (NSII) and non-specific abdominal pain (NSAP) at presentation yet carries 50\u201380% mortality. We tested how well admission data separate these conditions and predict in-hospital mortality, the primary endpoint. Methods: We studied 197 consecutive adults (2015\u20132021): AMI (n = 61), NSII (n = 62), and NSAP controls (n = 74). Admission demographics, comorbidities, laboratory markers, the Mannheim Peritonitis Index (MPI), and APACHE-II were compared by ROC\/DeLong analysis and multivariable logistic regression (STROBE). Results: AMI had more atrial fibrillation, thromboembolism, chronic kidney disease (CKD), and dyslipidemia (p \u2264 0.028) and higher in-hospital mortality than NSII (47.5% vs. 16.1%; p &lt; 0.001). Inflammatory ratios, lactate, and albumin separated AMI from NSAP well (AUC up to 0.93) but from NSII modestly (lactate, 0.672). APACHE-II (AUC 0.861) and MPI (0.810) predicted in-hospital death and improved combined (0.897; DeLong p = 0.014). Independent predictors were MPI (adjusted odds ratio 1.14, 95% CI 1.06\u20131.23), CKD (3.72, 1.25\u201312.10), and arterial lactate (1.20, 1.03\u20131.45). Conclusions: A composite admission panel was internally consistent but hypothesis-generating, not a triage tool ready for clinical use. CT angiography remains essential, since these markers cannot separate vascular from non-vascular ischemia; prospective external validation is required.<\/jats:p>","DOI":"10.3390\/jcm15166157","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:00:43Z","timestamp":1786118443000},"page":"6157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic and Prognostic Factors in Acute Intestinal Ischemia: A Comparative, Retrospective, Single-Center Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-6236","authenticated-orcid":false,"given":"Musa Murat","family":"\u00c7al\u0131\u015fkan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-7533","authenticated-orcid":false,"given":"Tahir Talat","family":"Yurtta\u015f","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0227-2953","authenticated-orcid":false,"given":"Selim","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-7809","authenticated-orcid":false,"given":"Ufuk O\u011fuz","family":"\u0130diz","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1974","authenticated-orcid":false,"given":"Kenan","family":"B\u00fcy\u00fcka\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3046-2084","authenticated-orcid":false,"given":"Ta\u015fk\u0131n","family":"Rak\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-9714","authenticated-orcid":false,"given":"Mert Mahsuni","family":"Sevin\u00e7","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Istanbul Training and Research Hospital, University of Health Sciences, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/TA.0000000000004585","article-title":"Diagnosis and Management of Acute Mesenteric Ischemia: What You Need to Know","volume":"99","author":"Tolonen","year":"2025","journal-title":"J. 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