{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:32:01Z","timestamp":1786440721671,"version":"build-2736575974"},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Acute deep vein thrombosis (DVT) continues to represent a significant global contributor to morbidity and mortality. Although multiple international societies have published evidence-based clinical practice guidelines, important differences persist. This structured narrative review compares contemporary international guidance to identify areas of consensus, methodological divergence, evidence gaps, and priorities for future research. Recommendations were compared across diagnostic evaluation, anticoagulant selection, treatment duration, outpatient management, compression therapy, endovascular intervention, and special populations. Broad agreement was identified regarding clinical pretest probability assessment, D-dimer testing, compression ultrasonography, and direct oral anticoagulants as first-line therapy for most eligible patients with acute DVT. Clinically important differences remain, however, in the management of isolated distal DVT, anticoagulation duration, catheter-directed interventions, compression therapy, and selected high-risk populations. These discrepancies primarily reflect differences in publication timing, methodological frameworks, interpretation of emerging evidence, and healthcare-system context rather than fundamentally conflicting evidence. Contemporary international guidance therefore demonstrates substantial convergence on the core principles of acute DVT management while continuing to differ in areas supported by limited or evolving evidence. Future harmonization will require high-quality randomized trials, broader international collaboration, and the integration of precision medicine, validated risk-prediction models, biomarkers, and emerging anticoagulant strategies into guideline development.<\/jats:p>","DOI":"10.3390\/jcm15166201","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:09:36Z","timestamp":1786435776000},"page":"6201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["International Clinical Practice Guidelines for Acute Deep Vein Thrombosis: A Comparative Review of Recommendations, Evidence Gaps, and Emerging Trends"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-623X","authenticated-orcid":false,"given":"Alejandro Jos\u00e9","family":"Gonzalez-Ochoa","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Centro M\u00e9dico del Noroeste, San Luis R\u00edo Colorado 83449, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-2073","authenticated-orcid":false,"given":"Juliana de Miranda","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Angiology, Pedro Ernesto University Hospital, State University of Rio de Janeiro (UERJ), Rio de Janeiro 20550, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery-Phlebology, Hospital Pasteur, Montevideo 11400, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-2105","authenticated-orcid":false,"given":"Joana","family":"Storino","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Rede Mater Dei de Sa\u00fade, Belo Horizonte 30190, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-9383","authenticated-orcid":false,"given":"Konstantinos","family":"Kavallieros","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Murayama","sequence":"additional","affiliation":[{"name":"Kannai Medical Clinic, Yokohama 231-0005, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Marie Yuja","family":"Valle","sequence":"additional","affiliation":[{"name":"Hospital Centro Urol\u00f3gico Hondure\u00f1o, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-4881","authenticated-orcid":false,"given":"Joana Margarida Magalh\u00e3es","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Angiology and Vascular Surgery, S\u00e3o Jo\u00e3o University Hospital, 4200-319 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Windsor","family":"Ting","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.5694\/mja2.50201","article-title":"Deep vein thrombosis: Update on diagnosis and management","volume":"210","author":"Kruger","year":"2019","journal-title":"Med. 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