{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:26:51Z","timestamp":1786685211615,"version":"build-2736575974"},"reference-count":43,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut universitaire en sant\u00e9 mentale de Montr\u00e9al"},{"id":[{"id":"https:\/\/ror.org\/02twt6343","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019217","name":"Institut de valorisation des donn\u00e9es","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100019217","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/05a3srq89","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020951","name":"Fonds de recherche du Qu\u00e9bec","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020951","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00w3qhf76","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Takotsubo cardiomyopathy (TTC), also known as \u201cbroken heart syndrome\u201d, is an acute and reversible cardiac condition often triggered by emotional or physical stress. Increasing evidence suggests a strong comorbidity between TTC and psychiatric disorders, particularly anxiety and depression. However, the nature, prevalence, and implications of these associations remain incompletely understood. This scoping review aimed to systematically map the available evidence on the association between Takotsubo cardiomyopathy and anxiety and depressive disorders, characterize the prevalence and nature of these psychiatric comorbidities, evaluate the methods used for their assessment, and identify knowledge gaps to guide future research and clinical practice. Methods: A systematic search of MEDLINE (via PubMed), Embase, Web of Science, and Google Scholar was conducted for peer-reviewed human studies published up to December 2025 in English or French. Eligible studies reported on psychiatric comorbidities in TTC populations, including pre-existing disorders, psychiatric triggers, or psychological sequelae. A standardized extraction grid and the Joanna Briggs Institute appraisal tools were used for data collection and quality assessment. Results: Eighteen studies were included. Depression and anxiety were prevalent among TTC patients, frequently preceding or accompanying cardiac events. Emotional stressors such as bereavement or panic attacks were commonly cited as triggers. Despite this, only a minority of studies used validated psychometric tools, and longitudinal psychiatric follow-up was rare. Most studies were limited by small sample sizes, retrospective designs, and heterogeneity in diagnostic approaches. Conclusions: The findings reveal a consistent association between TTC and affective disorders, underscoring the role of the brain\u2013heart axis. Integrating psychiatric screening and follow-up into TTC management may enhance outcomes. Future interdisciplinary research is needed to clarify causal pathways and inform prevention and treatment strategies.<\/jats:p>","DOI":"10.3390\/jcm15166242","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:02:11Z","timestamp":1786532531000},"page":"6242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging Minds and Hearts by Exploring the Comorbidities Between Anxiety, Depression, and Takotsubo Cardiomyopathy: A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Michael Trung","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Addictology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, 2900 Bd \u00c9douard-Montpetit, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Fajraoui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, 2900 Bd \u00c9douard-Montpetit, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-0928","authenticated-orcid":false,"given":"Alexandre","family":"Hudon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, 2900 Bd \u00c9douard-Montpetit, Montreal, QC H3T 1J4, Canada"},{"name":"Department of Psychiatry, Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al, 7401 Rue Hochelaga, Montreal, QC H1N 3M5, Canada"},{"name":"Centre de Recherche de l\u2019Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al, 7331 Rue Hochelaga, Montreal, QC H1N 3V2, Canada"},{"name":"Department of Psychiatry, Institut National de Psychiatrie L\u00e9gale Philippe-Pinel, 10905 Boul Henri-Bourassa E, Montreal, QC H1C 1H1, Canada"},{"name":"Groupe Interdisciplinaire de Recherche sur la Cognition et le Raisonnement Professionnel, Universit\u00e9 de Montr\u00e9al, 2900 Bd \u00c9douard-Montpetit, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Marano, G., Romagnoli, E., Biondi-Zoccai, G., Traversi, G., Mazza, O., Pola, R., Gaetani, E., and Mazza, M. 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