{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:35:40Z","timestamp":1786628140425,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Proactively informing the patient prior to initiating medication and implementing preventive strategies are essential for mitigating the risk of developing medication-related osteonecrosis of the jaw (MRONJ). This study evaluated the awareness of MRONJ among a group of dental faculty patients who were scheduled to use, were using, or had previously utilized bisphosphonate and\/or denosumab. Methods: A structured questionnaire-based survey was used as the survey tool to evaluate the patients\u2019 awareness of MRONJ. A non-probability convenience sampling method was employed throughout a one-year period. Results: Throughout the study period, 202 participants were included, with a response rate of 97.58%. Only 35 (17.3%) of the patients had awareness of the risk of MRONJ, and 23 (11.4%) reported that their prescribing physicians had informed them about the potential side effects of their medication before the commencement of treatment. Univariate logistic regression, which was performed to elucidate the elements affecting awareness, revealed a significant odds ratio for healthcare professionals as a source of knowledge (29.229, p &lt; 0.001), information of side effects given by a prescribing physician (25.343, p &lt; 0.001), dental consultation (2.592, p = 0.018), and regular dental visits (3.205, p = 0.004). In the multivariate logistic regression analysis, \u201cHealthcare professional as source of knowledge\u201d was significantly associated with awareness (OR = 21.956, p &lt; 0.001). \u201cInformation of side effects given by a prescribing physician\u201d was also a significant predictor (OR = 11.450, p &lt; 0.001), indicating that participants informed by prescribing physicians about the side effects were more likely to have awareness. Conclusions: This study revealed that despite patients\u2019 limited awareness of MRONJ, the dissemination of information by healthcare professionals positively influenced their awareness and understanding of the risk factors associated with MRONJ. In particular, receiving information from healthcare professionals and prescribing physician-provided information about side effects appeared to be the strongest predictors of awareness.<\/jats:p>","DOI":"10.3390\/jcm15166280","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:47:11Z","timestamp":1786625231000},"page":"6280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Prescription to Prevention: Patient Awareness, Risk Perceptions, and Predictors of Knowledge of Medication-Related Osteonecrosis of the Jaw"],"prefix":"10.3390","volume":"15","author":[{"given":"G\u00f6k\u00e7en","family":"Ak\u00e7i\u00e7ek","sequence":"first","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Hacettepe University, S\u0131hhiye, 06100 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-2324","authenticated-orcid":false,"given":"M\u00fcnevver Gamze","family":"Diricanli","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Hacettepe University, S\u0131hhiye, 06100 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2854-1138","authenticated-orcid":false,"given":"Nursel","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Hacettepe University, S\u0131hhiye, 06100 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons\u2019 Position Paper on Medication-Related Osteonecrosis of the Jaws\u20142022 Update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1111\/odi.14887","article-title":"Italian position paper (SIPMO-SICMF) on medication-related osteonecrosis of the jaw (MRONJ)","volume":"30","author":"Bedogni","year":"2024","journal-title":"Oral Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/bcr414","article-title":"The role of bisphosphonates in breast cancer: Development of bisphosphonates","volume":"4","author":"Fleisch","year":"2002","journal-title":"Breast Cancer Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_6","first-page":"6359","article-title":"Oral bisphosphonate-induced osteonecrosis complications in patients undergoing tooth extraction: A systematic review and literature updates","volume":"27","author":"Dioguardi","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.7181\/acfs.2024.0091","article-title":"Multidisciplinary approach for medication-related osteonecrosis of the jaws: A case report and literature review","volume":"26","author":"Annamalai","year":"2025","journal-title":"Arch. Craniofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105852","DOI":"10.1016\/j.oraloncology.2022.105852","article-title":"Osteonecrosis of the jaw induced by bisphosphonates therapy in bone metastases patient: Case report and literature review","volume":"128","author":"Hao","year":"2022","journal-title":"Oral Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.bdj.2017.79","article-title":"Awareness of medication related osteonecrosis of the jaws (MRONJ) amongst general dental practitioners","volume":"222","author":"Tanna","year":"2017","journal-title":"Br. Dent. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s11914-020-00612-4","article-title":"Benefits of bisphosphonate therapy: Beyond the skeleton","volume":"18","author":"Billington","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.oooo.2025.08.011","article-title":"Osteonecrosis of the jaw as a possible adverse effect of tocilizumab","volume":"141","author":"Samady","year":"2026","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40729-021-00323-0","article-title":"Clinical considerations for medication-related osteonecrosis of the jaw: A comprehensive literature review","volume":"7","author":"Kawahara","year":"2021","journal-title":"Int. J. Implant Dent."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e024376","DOI":"10.1136\/bmjopen-2018-024376","article-title":"Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): A qualitative study in England","volume":"9","author":"Sturrock","year":"2019","journal-title":"BMJ Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jcms.2011.04.011","article-title":"Awareness and education of patients receiving bisphosphonates","volume":"40","author":"Bauer","year":"2012","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/annonc\/mdr039","article-title":"Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: A single-center clinical experience","volume":"23","author":"Vandone","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1200\/JCO.2008.16.2768","article-title":"Bisphosphonate-related osteonecrosis of the jaws: A case-control study of risk factors in breast cancer patients","volume":"26","author":"Kyrgidis","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mauceri, R., Arduini, S., Coppini, M., Bazzano, M., Trujillo, I., and Campisi, G. (2024). Drug assumption and awareness about adverse drug reactions. The right to know. The case of the bone-modifying agents: A systematic review. Front. Oral Health, 5.","DOI":"10.3389\/froh.2024.1441601"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jsps.2020.05.004","article-title":"Awareness among patient at risk of developing Medication Related Osteonecrosis of the Jaw (MRONJ)\u2014A primary prevention strategy","volume":"28","author":"Alhareky","year":"2020","journal-title":"Saudi Pharm. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"300060520955066","DOI":"10.1177\/0300060520955066","article-title":"Awareness of the risk of developing medication-related osteonecrosis of the jaw among bisphosphonate users","volume":"48","author":"Hassona","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mutlu, M., Altundo\u011fan, S., and Kocamaz, \u00d6.F. (2025). Awareness and Attitude Towards MRONJ Among Physicians Prescribing Antiresorptive Drugs: A Cross-Sectional Study. BMC Oral Health, 25.","DOI":"10.1186\/s12903-025-06490-5"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jcms.2019.02.006","article-title":"A cross-sectional survey on medication-related osteonecrosis of the jaws\u2019 knowledge and awareness in a sample of dental society","volume":"47","year":"2019","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101707","DOI":"10.1016\/j.jsps.2023.101707","article-title":"Awareness, perceptions and attitudes toward medication related osteonecrosis of the jaw among physicians who treat osteoporosis","volume":"31","author":"Aljohani","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kim, J.W., Jeong, S.R., Kim, S.J., and Kim, Y. (2016). Perceptions of medical doctors on bisphosphonate-related osteonecrosis of the jaw. BMC Oral Health, 16.","DOI":"10.1186\/s12903-016-0290-0"},{"key":"ref_24","first-page":"5397","article-title":"Current knowledge regarding medication-related osteonecrosis of the jaw among different health professionals","volume":"28","author":"Montezuma","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_25","first-page":"e52896","article-title":"Awareness of medication-related osteonecrosis of the jaws amongst patients on antiresorptive and antiangiogenic medications","volume":"16","author":"Assari","year":"2024","journal-title":"Cureus"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"562","DOI":"10.14219\/jada.archive.2010.0229","article-title":"How patients\u2019 lack of knowledge about oral bisphosphonates can interfere with medical and dental care","volume":"141","author":"Migliorati","year":"2010","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.joms.2021.12.007","article-title":"Prevalence, incidence rate, and risk factors of medication-related osteonecrosis of the jaw in patients with osteoporosis and cancer: A nationwide population-based study in Japan","volume":"80","author":"Ishimaru","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_28","unstructured":"United Nations (2026, June 30). Available online: https:\/\/www.un.org\/en\/global-issues\/ageing."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.oooo.2018.02.003","article-title":"Medication-related osteonecrosis of the jaw: An update on the memorial sloan kettering cancer center experience and the role of premedication dental evaluation in prevention","volume":"125","author":"Owosho","year":"2018","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1210\/jc.2015-1794","article-title":"Declining incidence of medication-related osteonecrosis of the jaw in patients with cancer","volume":"100","author":"Sim","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e0126","DOI":"10.1590\/1807-3107bor-2022.vol36.0126","article-title":"Awareness of patients receiving bisphosphonates: A cross-sectional study","volume":"36","author":"Leonel","year":"2022","journal-title":"Braz. Oral Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.bdj.2014.806","article-title":"Legal liability in bisphosphonate-related osteonecrosis of the jaw","volume":"217","author":"Ciavarella","year":"2014","journal-title":"Br. Dent. J."},{"key":"ref_33","first-page":"505","article-title":"Awareness about medication-related osteonecrosis of the jaw among dental professionals: A multicentre study","volume":"18","author":"Patil","year":"2020","journal-title":"Oral Health Prev. Dent."},{"key":"ref_34","first-page":"859","article-title":"Osteonecrosis of the jaws: The awareness of the patient at risk","volume":"1","author":"Alessandra","year":"2017","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/ors.12372","article-title":"A survey evaluating the awareness of MRONJ within the Birmingham GMP community","volume":"12","author":"Rahman","year":"2019","journal-title":"Oral Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e70024","DOI":"10.1002\/cre2.70024","article-title":"Education and communication on the topic of osteonecrosis of the jaw when taking bone-stabilizing drugs","volume":"10","author":"Saur","year":"2024","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_37","first-page":"5544285","article-title":"Medication-Related Osteonecrosis of the Jaw: A case report of an unusual side effect of adalimumab","volume":"15","author":"Sisalli","year":"2023","journal-title":"Case Rep. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41415-025-8643-1","article-title":"A literature review and update on medications related to osteonecrosis of the jaw independent of bisphosphonates and denosumab","volume":"239","author":"Jawad","year":"2025","journal-title":"Br. Dent. J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/16\/6280\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:56:27Z","timestamp":1786625787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/16\/6280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":38,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["jcm15166280"],"URL":"https:\/\/doi.org\/10.3390\/jcm15166280","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}