{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:35:11Z","timestamp":1786725311235,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Single-access transfemoral transcatheter aortic valve implantation (TAVI) reduces the need for multiple vascular access and therefore, the related risk of related complications. However, the impact of patient age on its clinical outcomes remains uncertain. Methods: This is a secondary analysis of previously reported propensity score matched study comparing clinical outcomes of single- versus dual-access transfemoral TAVI using SAPIEN-3-Ultra. We examined the relation between patient age, access strategy and outcomes\u2014specifically, 30-day safety endpoint according to the Valve Academic Research Consortium 3 (VARC-3) and major adverse cardiovascular events (MACE), defined as death, permanent pacemaker, neurological or vascular complications\u2014using logistic regression interaction analyses, and restricted cubic spline modelling. Results: A total of 204 patients (propensity score-matched cohort) were included in the study. The elderly group were more likely to have hypertension, peripheral vascular disease or stroke. The use of single access was comparable. The elderly cohort demonstrated a tendency toward longer fluoroscopy and procedural times compared with the non-elderly group. This pattern likely reflects the greater technical complexity and heightened procedural caution often associated with older patients, including more challenging vascular anatomy and the need for careful device handling. Although not statistically significant, these findings remain clinically meaningful and are consistent with the notion that procedures in elderly patients frequently require more meticulous planning and execution. There was a significant interaction between access strategy and age in reducing MACE, but not in VARC-3 safety outcomes. Single access was associated with a significant reduction in MACE (5.4% vs. 26.7%, p = 0.015) with comparable technical and safety outcomes when compared with elderly patients who underwent dual-access TAVI. Conclusions: Single-access TAVI was linked to favourable early outcomes, maintained procedural success, and suggested a possible age-dependent pattern in the occurrence of MACE. Our findings support the need for randomised studies to demonstrate superiority of single- versus dual-access TAVI, particularly in the elderly population.<\/jats:p>","DOI":"10.3390\/jcm15166305","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:48:36Z","timestamp":1786722516000},"page":"6305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-Access Transfemoral TAVI with a Balloon Expandable Valve: Age-Stratified Analysis of Clinical Outcomes"],"prefix":"10.3390","volume":"15","author":[{"given":"Sushant","family":"Saluja","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3011-9824","authenticated-orcid":false,"given":"Muntaser","family":"Omari","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-8843","authenticated-orcid":false,"given":"Omran","family":"Abukhalaf","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Stewart","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lamb","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Cartlidge","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Edwards","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Das","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-8892","authenticated-orcid":false,"given":"Azfar","family":"Zaman","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-7679","authenticated-orcid":false,"given":"Mohamed","family":"Farag","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-8878","authenticated-orcid":false,"given":"Mohammad","family":"Alkhalil","sequence":"additional","affiliation":[{"name":"Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK"},{"name":"Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne NE2 4AE, UK"},{"name":"Department of Cardiothoracic Services, Freeman Hospital, Freeman Road, Newcastle-upon-Tyne NE7 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. 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