{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:26:05Z","timestamp":1786940765257,"version":"build-2736575974"},"reference-count":191,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Introduction: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cardiovascular disorder and a leading cause of vascular mortality. MicroRNAs (miRNAs) are small endogenous noncoding RNAs that regulate gene expression post-transcriptionally by binding to the target messenger RNAs (mRNAs), inducing mRNA degradation or translational repression. miRNA dysregulation likely contributes to VTE pathogenesis. This review comprehensively summarizes current evidence on miRNAs in VTE, offering a structured overview of the existing literature. Materials and Methods: Eligibility criteria were defined using the Population, Intervention\/Exposure, Comparator, Outcomes, and Study design (PICOS) framework. A comprehensive literature search in PubMed and EMBASE was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Given methodological heterogeneity, a narrative synthesis was undertaken. Results: Among the 156 studies included in this review, 99 investigated miRNAs in DVT, 25 examined the role of miRNAs in PE, and 32 evaluated miRNA involvement in VTE. These miRNAs were categorized as prothrombotic, antithrombotic, or unclassified based on their reported functional roles. Conclusions: This systematic review highlights the impact of miRNAs in the pathophysiology of VTE and provides a resource for future mechanistic and translational research. The findings emphasize the need for standardized, large-scale studies focusing on human-specific models to validate miRNAs as diagnostic, prognostic biomarkers, and as therapeutic targets in VTE.<\/jats:p>","DOI":"10.3390\/jcm15166306","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:48:36Z","timestamp":1786722516000},"page":"6306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Circulating MicroRNAs as Biomarkers and Therapeutic Targets in Venous Thromboembolism: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3060-721X","authenticated-orcid":false,"given":"Bulent","family":"Kantarcioglu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, University of Health Sciences, Sancaktepe Sehit Prof. Dr. Ilhan Varank, Training and Research Hospital, 34785 Istanbul, T\u00fcrkiye"},{"name":"Department of Pathology and Laboratory Medicine, Health Sciences Division, Cardiovascular Research Institute, Loyola University Chicago, Maywood, IL 60153, USA"},{"name":"Department of Molecular Pharmacology and Neuroscience, Health Sciences Division, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3791-9157","authenticated-orcid":false,"given":"Hande Nur","family":"Er\u00f6lmez","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Health Sciences, Umraniye Training and Research Hospital, 34764 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5625-7005","authenticated-orcid":false,"given":"Mira","family":"Nigudkar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Loyola University Stritch School of Medicine, Chicago, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lundy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Loyola University Stritch School of Medicine, Chicago, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-7049","authenticated-orcid":false,"given":"Fakiha","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Health Sciences Division, Cardiovascular Research Institute, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-0339","authenticated-orcid":false,"given":"Prakasha","family":"Kempaiah","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Neuroscience, Health Sciences Division, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5455-2585","authenticated-orcid":false,"given":"Chongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Neuroscience, Health Sciences Division, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2316-6348","authenticated-orcid":false,"given":"Grigoris","family":"Gerotziafas","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Thrombosis Center, Service D\u2019H\u00e9matologie Biologique H\u00f4pital Tenon, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter Keith","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Neuroscience, Health Sciences Division, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Health Sciences Division, Cardiovascular Research Institute, Loyola University Chicago, Maywood, IL 60153, USA"},{"name":"Department of Molecular Pharmacology and Neuroscience, Health Sciences Division, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41569-022-00787-6","article-title":"Epidemiology and prevention of venous thromboembolism","volume":"20","author":"Lutsey","year":"2023","journal-title":"Nat. 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