{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:26:46Z","timestamp":1787113606153,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031688","name":"Pfizer Pharma GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100031688","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Open Access Publication Fund of the Justus-Liebig-University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Patients with transthyretin amyloidosis frequently experience reduced quality of life, distress, anxiety and depression. But the evidence is inconsistent and the constructs are often not clearly separated. This study assessed quality of life and mental health symptoms in wild-type transthyretin amyloidosis (ATTRwt). Methods: Within the amyloidosis cohort study AmyKoS, 113 patients with confirmed ATTRwt amyloidosis completed a structured survey between July 2020 and February 2024, assessing quality of life (Short Form (36) Health Survey, SF-36), distress (Distress Thermometer), anxiety (Generalized Anxiety Disorder-7, GAD-7), depression (Patient Health Questionnaire-9, PHQ-9), fear of progression (Fear of Progression Questionnaire, short form; PA-F-KF), fatigue and dyspnea. Results: Of 113 patients (age 78.95 \u00b1 5.90 years, 14.2% female), 88.4% reported restricted quality of life and 62.7% screened positive for distress. Overall, 26.4% screened positive for anxiety and\/or depression and 9.2% for fear of progression. Both SF-36 summary scales were reduced to a comparable degree relative to the age-matched general population: physical component summary 36.9 \u00b1 9.8 versus 43.5 \u00b1 11.8 and mental component summary 46.8 \u00b1 9.1 versus 52.2 \u00b1 10.3 (both p &lt; 0.001, Cohen\u2019s d = \u22120.59 and \u22120.54). Notably, 59.4% of distress-positive patients screened positive for neither anxiety nor depression, and fatigue was the key predictor. Conclusions: In ATTRwt amyloidosis, both dimensions of health-related quality of life are substantially impaired. Stepwise screening should be routine, and many burdened patients are likely to benefit primarily from symptom control and rehabilitation rather than psychiatric treatment.<\/jats:p>","DOI":"10.3390\/jcm15166348","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:01:26Z","timestamp":1786968086000},"page":"6348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psycho-Emotional Profile and Disease Burden in Wild-Type Transthyretin Amyloidosis"],"prefix":"10.3390","volume":"15","author":[{"given":"Sandra Michaela","family":"Ihne-Schubert","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV, University Hospital of Gie\u00dfen and Marburg, Justus-Liebig-University Gie\u00dfen, 35392 Gie\u00dfen, Germany"},{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"CIRCLE\u2014Centre for Innovation Research, Lund University, Box 118, 221 00 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Weidgans","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Clinical Division of General Anaesthesia and Intensive Care Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Leberzammer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Sch\u00fctt","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Anesthesiology, Regionale Kliniken Holding (RKH) Klinikum Ludwigsburg, 71640 Ludwigsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-0632","authenticated-orcid":false,"given":"Aikaterini","family":"Papagianni","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Neurology, University Hospital Ulm, 89081 Ulm, Germany"},{"name":"Department of Neurology, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-6094","authenticated-orcid":false,"given":"Caroline","family":"Morbach","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine I, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, University Hospital of Gie\u00dfen and Marburg, Justus-Liebig-University Gie\u00dfen, 35392 Gie\u00dfen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wehler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, University Hospital of Gie\u00dfen and Marburg, Justus-Liebig-University Gie\u00dfen, 35392 Gie\u00dfen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7680-0819","authenticated-orcid":false,"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Neurology, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Geier","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine II, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-7249","authenticated-orcid":false,"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[{"name":"Interdisciplinary Amyloidosis Center of Northern Bavaria, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center (CHFC), University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"},{"name":"Department of Internal Medicine I, University Hospital of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-0259","authenticated-orcid":false,"given":"Silke","family":"Neuderth","sequence":"additional","affiliation":[{"name":"Institute for Applied Social Sciences (IFAS), Technical University of Applied Sciences W\u00fcrzburg-Schweinfurt (THWS), 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11897-019-00446-x","article-title":"Amyloidosis in Heart Failure","volume":"16","author":"Ihne","year":"2019","journal-title":"Curr. 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