{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:25:11Z","timestamp":1787045111964,"version":"build-2736575974"},"reference-count":26,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["Q23H160110"],"award-info":[{"award-number":["Q23H160110"]}]},{"award":["Q23H160110"],"award-info":[{"award-number":["Q23H160110"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Lung cancer is increasingly recognized in young adults, but data specific to patients younger than 30 years remain scarce. We aimed to characterise the clinicopathological features, molecular profiles, and survival outcomes of lung cancer in adults younger than 30 years. Methods: A retrospective cohort study was conducted at the Department of Respiratory Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Patients aged 18 to 30 years with pathologically confirmed primary lung cancer, admitted between August 2011 and October 2021, were identified from the pathology and oncology databases of the study centre; eligibility and exclusion criteria and the resulting analytic cohort are summarized below (a screened\/excluded patient count could not be reconstructed retrospectively; see Limitations). Demographics, histology, stage (eighth-edition TNM), driver mutations, and treatment were extracted, and the extent of missing data for each variable was assessed. Molecular testing was not performed prospectively for this study; rather, we report driver-mutation results that had already been generated as part of routine clinical care for patients in whom testing was clinically indicated and archived tissue was available. Overall survival (OS) was estimated using the Kaplan\u2013Meier method and compared using the log-rank test; hazard ratios (HRs) were derived from univariate Cox regression and are reported as exploratory\/descriptive given the non-randomized comparison (see Discussion). Results: Among 139 patients meeting eligibility criteria, the cohort was predominantly female (65.5%) and most individuals were never-smokers (92.8%), with adenocarcinoma predominating (93.5%). Stage I (61.2%) and stage IV (30.2%) were most common. Of 34 patients (24.5%) with available molecular testing results, 23 (67.6%) carried a driver mutation, of whom 19 (82.6%) had stage IV disease. Among mutation-positive patients\u2014drawn from a selectively tested subcohort enriched for advanced-stage disease\u2014ALK rearrangement was most frequent (13; 56.5%). In the stage IV subgroup, patients who received first-line tyrosine kinase inhibitors (TKIs) had a longer observed OS than those who did not (median, 88 vs. 24 months); this exploratory, non-randomized comparison is reported descriptively rather than as an adjusted treatment-effect estimate (see Limitations). Conclusions: In this single-centre retrospective cohort, adults aged &lt;30 years with lung cancer were predominantly female never-smokers with adenocarcinoma. Among the selectively tested advanced-stage subgroup, ALK fusions were common. These data justify further multicentre study and broader contemporary molecular characterisation.<\/jats:p>","DOI":"10.3390\/jcm15166360","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:08:41Z","timestamp":1787040521000},"page":"6360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Characteristics, Molecular Findings, and Survival of Lung Cancer in Adults Aged &lt;30 Years in China: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Jingchen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Disease, Thoracic Disease Centre, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianya","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Thoracic Disease Centre, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chen, L., Wang, J., and Qu, J. (2025). The burden of interstitial lung disease and pulmonary sarcoidosis lung cancer among adolescents and young adults from 1990 to 2021 and its projections: A comparative study between China and other G20 countries. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1680118"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1038\/s41598-021-86203-4","article-title":"Epidemiology and prognosis in young lung cancer patients aged under 45 years old in northern China","volume":"11","author":"Shi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.21037\/jtd-2024-1950","article-title":"Lung cancer in young individuals; risk factors and epidemiology","volume":"17","author":"Sumiya","year":"2025","journal-title":"J. Thorac. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00408-019-00294-5","article-title":"Lung cancer in the young","volume":"198","author":"Ruiz","year":"2020","journal-title":"Lung"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"152407","DOI":"10.1016\/j.prp.2019.03.035","article-title":"Unique profiles of targetable genomic alterations and prognosis in young Chinese patients with lung adenocarcinoma","volume":"215","author":"Chen","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/cncr.30539","article-title":"Unique prevalence of oncogenic genetic alterations in young patients with lung adenocarcinoma","volume":"123","author":"Tanaka","year":"2017","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/ijc.33583","article-title":"The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients","volume":"149","author":"Cai","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/jamaoncol.2015.4482","article-title":"Association between younger age and targetable genomic alterations and prognosis in non-small-cell lung cancer","volume":"2","author":"Sacher","year":"2016","journal-title":"JAMA Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s12094-018-1838-z","article-title":"Frequent genomic alterations and better prognosis among young patients with non-small-cell lung cancer aged 40 years or younger","volume":"20","author":"Pan","year":"2018","journal-title":"Clin. Transl. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/s41467-025-57309-4","article-title":"Comprehensive characterization of early-onset lung cancer in Chinese young adults","volume":"16","author":"Tian","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"De Guzman, R.B. (2025). Early-onset lung cancer in Asia: A narrative review. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1631443"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Liang, D., Wang, J., Li, D., Shi, J., Jing, J., Shan, B., and He, Y. (2019). Lung cancer in never-smokers: A multicenter case-control study in North China. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.01354"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1158\/0008-5472.CAN-20-3991","article-title":"Association between smoking history and tumor mutation burden in advanced non-small cell lung cancer","volume":"81","author":"Wang","year":"2021","journal-title":"Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1759-7714.2011.00067.x","article-title":"Attributable causes of lung cancer incidence and mortality in China","volume":"2","author":"Wang","year":"2011","journal-title":"Thorac. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"89236","DOI":"10.18632\/oncotarget.19183","article-title":"Characteristics, survival, and risk factors of Chinese young lung cancer patients: The experience from two institutions","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/annonc\/mdu470","article-title":"Active and passive smoking in relation to lung cancer incidence in the Women\u2019s Health Initiative Observational Study prospective cohort","volume":"26","author":"Wang","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40169-018-0217-2","article-title":"The role of environmental exposure to non-cigarette smoke in lung disease","volume":"7","author":"Kc","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/ijc.34508","article-title":"Female reproductive and hormonal factors and lung cancer mortality among never-smokers: A prospective cohort study of 287,408 Chinese women","volume":"152","author":"Cheng","year":"2023","journal-title":"Int. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mulita, A., Valsamaki, P., Bekou, E., Anevlavis, S., Nanos, C., Zisimopoulos, A., Giatromanolaki, A., and Koukourakis, M.I. (2025). Benefits from 18F-FDG PET-CT-based radiotherapy planning in stage III non-small-cell lung cancer: A prospective single-center study. Cancers, 17.","DOI":"10.3390\/cancers17121969"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1002367","DOI":"10.37349\/etat.2026.1002367","article-title":"Solitary fibrous tumor of the lung: Diagnostic challenges and surgical management","volume":"7","author":"Leivaditis","year":"2026","journal-title":"Explor. Target. Antitumor Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.32604\/or.2024.050350","article-title":"Inflammatory myofibroblastic tumor: From molecular diagnostics to current treatment","volume":"32","author":"Chmiel","year":"2024","journal-title":"Oncol. Res."},{"key":"ref_24","first-page":"70","article-title":"Symmetric lung injury computed tomography pattern in pembrolizumab-induced severe pneumonitis","volume":"22","author":"Stefanidis","year":"2025","journal-title":"Kardiochir. Torakochirurgia Pol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dell\u2019Amore, A., Campisi, A., Bertolaccini, L., Chen, C., Gabryel, P., Ji, C., Piwkowski, C., Spaggiari, L., Fang, W., and Rea, F. (2022). A multicenter retrospective cohort study on superior vena cava resection in non-small-cell lung cancer surgery. Cancers, 14.","DOI":"10.3390\/cancers14246138"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(21)02333-3","article-title":"Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802\/WJOG4607L): A multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial","volume":"399","author":"Saji","year":"2022","journal-title":"Lancet"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/16\/6360\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:31:56Z","timestamp":1787041916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/16\/6360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":26,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["jcm15166360"],"URL":"https:\/\/doi.org\/10.3390\/jcm15166360","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}