{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:18:19Z","timestamp":1787890699139,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Jishuitan Hospital Natural Science Foundation","award":["ZR-202609"],"award-info":[{"award-number":["ZR-202609"]}]},{"award":["ZR-202609"],"award-info":[{"award-number":["ZR-202609"]}],"id":[{"id":"https:\/\/ror.org\/035t17984","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["7232073"],"award-info":[{"award-number":["7232073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: This study aimed to evaluate whether preoperative anxiety and\/or depression (AD) is associated with mid-term lateral compartment osteoarthritis progression (LOP) after medial unicompartmental knee arthroplasty (mUKA). Methods: This retrospective observational cohort study analyzed a prospectively maintained institutional database of consecutive patients who underwent mUKA between March 2016 and December 2020. Preoperative psychological status was assessed using the Hospital Anxiety and Depression Scale (HADS); patients with subscore \u22658 were categorized as having AD. Clinical outcomes included Oxford Knee Score (OKS), Forgotten Joint Score (FJS), Kujala score, and complications at a mean follow-up of 70 months. Serial full-length standing radiographs were used to measure coronal alignment and Kellgren\u2013Lawrence (K\/L) grade in the lateral compartment. LOP was defined as an increase of \u22651 K\/L grade between the early postoperative and final follow-up radiographs. Univariate and multivariable logistic regression were used to identify factors associated with LOP. Results: A total of 203 knees met the inclusion criteria; 26 knees were classified into the AD group and 177 into the Non-AD group. At final follow-up, the AD group had worse OKS, smaller OKS improvement, and lower FJS and Kujala scores. Radiographic follow-up was available in 99 knees. LOP occurred in 26.3% of knees overall. The rate of LOP was significantly higher in the AD group than in the Non-AD group (60.0% vs. 20.2%). In univariate analysis, AD was associated with LOP. In multivariable logistic regression, preoperative AD remained associated with a higher likelihood of LOP after adjustment for prespecified covariates. Conclusions: Preoperative anxiety and\/or depression was associated with a higher frequency of radiographic lateral compartment osteoarthritis progression and worse mid-term patient-reported outcomes after mUKA. These findings should be considered exploratory and hypothesis-generating.<\/jats:p>","DOI":"10.3390\/jcm15176568","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:11:15Z","timestamp":1787731875000},"page":"6568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Anxiety and Depression Are Associated with Lateral Compartment Osteoarthritis Progression After Medial Unicompartmental Knee Arthroplasty: A Retrospective Observational Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Knee Preservation Surgery, Beijing Jishuitan Hospital, Capital Medical University, 68 Huanan North Road, Huilongguan Street, Changping District, Beijing 102200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Knee Preservation Surgery, Beijing Jishuitan Hospital, Capital Medical University, 68 Huanan North Road, Huilongguan Street, Changping District, Beijing 102200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"An","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Knee Preservation Surgery, Beijing Jishuitan Hospital, Capital Medical University, 68 Huanan North Road, Huilongguan Street, Changping District, Beijing 102200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Knee Preservation Surgery, Beijing Jishuitan Hospital, Capital Medical University, 68 Huanan North Road, Huilongguan Street, Changping District, Beijing 102200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.2106\/JBJS.L.00799","article-title":"The role of emotional health in functional outcomes after orthopaedic surgery: Extending the biopsychosocial model to orthopaedics: AOA critical issues","volume":"95","author":"Ayers","year":"2013","journal-title":"J. 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