{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:52Z","timestamp":1788243352383,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heilongjiang Province Young Science and Technology Talent Lifting Project","award":["2024QNTJ013"],"award-info":[{"award-number":["2024QNTJ013"]}]},{"name":"First Affiliated Hospital of Harbin Medical University","award":["2024YQ15"],"award-info":[{"award-number":["2024YQ15"]}]},{"award":["2024YQ15"],"award-info":[{"award-number":["2024YQ15"]}],"id":[{"id":"https:\/\/ror.org\/05vy2sc54","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Heilongjiang Province Health Commission Scientific Research Project","award":["20250303010528"],"award-info":[{"award-number":["20250303010528"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibility and short-term outcomes of percutaneous endocardial septal pulsed field ablation in patients with symptomatic hypertrophic obstructive cardiomyopathy. Methods: Five patients with symptomatic hypertrophic obstructive cardiomyopathy and persistent left ventricular outflow tract obstruction despite optimized conventional medical therapy underwent percutaneous endocardial septal pulsed field ablation guided by intracardiac echocardiography and 3-dimensional electroanatomical mapping. Results: Two-month follow-up data were available for all patients. Mean resting and provoked left ventricular outflow tract gradients decreased from 60.20 \u00b1 14.10 and 93.60 \u00b1 17.73 mmHg at baseline to 20.60 \u00b1 5.18 and 27.80 \u00b1 9.37 mmHg at 2 months, respectively. Improvements were also observed in systolic anterior motion, symptoms, 6 min walk distance, and Kansas City Cardiomyopathy Questionnaire score. One patient developed transient left bundle branch block and another transient complete atrioventricular block during the procedure; neither persisted. No persistent major procedure-related complications were observed during follow-up. Conclusions: In this small first-in-human case series, percutaneous endocardial septal pulsed field ablation was feasible and was associated with favorable short-term hemodynamic and clinical changes in selected patients with symptomatic hypertrophic obstructive cardiomyopathy. These findings are hypothesis-generating and require confirmation in larger studies with longer follow-up.<\/jats:p>","DOI":"10.3390\/jcm15176620","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:58:21Z","timestamp":1787828301000},"page":"6620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series"],"prefix":"10.3390","volume":"15","author":[{"given":"Haoruo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"},{"name":"Department of Cardiology, Second Affiliated Hospital, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyue","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6596-7960","authenticated-orcid":false,"given":"Zhaojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/CIRCULATIONAHA.106.644682","article-title":"Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction","volume":"114","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1161\/CIR.0000000000001250","article-title":"2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Ommen","year":"2024","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.jacc.2015.06.1333","article-title":"Low Operative Mortality Achieved With Surgical Septal Myectomy: Role of Dedicated Hypertrophic Cardiomyopathy Centers in the Management of Dynamic Subaortic Obstruction","volume":"66","author":"Maron","year":"2015","journal-title":"J. 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