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Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Iurciuc, M., Gaita, D., Iurciuc, S., Avram, C., Craciun, L., and Avram, C. (2012). From Guideline to Clinical Practice\u2014Reinforced Primary Care at High-Risk Patients. 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Cells, 14.","DOI":"10.3390\/cells14050324"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCRESAHA.121.318158","article-title":"Mechanisms and Models in Heart Failure","volume":"128","author":"Mann","year":"2021","journal-title":"Circ. Res."},{"key":"ref_10","first-page":"1107","article-title":"Atherosclerotic Features in Patients with Heart Failure","volume":"21","author":"Ceasovschih","year":"2025","journal-title":"Arch. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1161\/CIRCRESAHA.124.323659","article-title":"Myocardial Inflammation in Heart Failure with Reduced and Preserved Ejection Fraction","volume":"134","author":"Alcaide","year":"2024","journal-title":"Circ. Res."},{"key":"ref_12","first-page":"e28605","article-title":"Inflammation as a Prognostic Marker in Heart Failure","volume":"14","author":"Lima","year":"2022","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.2147\/JIR.S514192","article-title":"Inflammation-Driven Prognosis in Advanced Heart Failure: A Machine Learning-Based Risk Prediction Model for One-Year Mortality","volume":"18","author":"Zhou","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","article-title":"Inflammation in Heart Failure","volume":"75","author":"Murphy","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.37358\/MP.19.1.5118","article-title":"Aspects of Heart Failure in Patients with Ischemic Heart Disease after Percutaneous Coronary Revascularization with Polymer-Coated Drug-Eluting Stents versus Bare-Metal Stents","volume":"56","author":"Tudoran","year":"2019","journal-title":"Mater. Plast."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"104409","DOI":"10.1016\/j.numecd.2025.104409","article-title":"The Role of Inflammation in Acute Coronary Syndrome: A Systematic Review on Biochemical Inflammatory Assessment and Anti-Inflammatory Therapies","volume":"36","author":"Intravaia","year":"2026","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"B\u0103ghin\u0103, R.-M., Cri\u0219an, S., Luca, S., P\u0103tru, O., Laz\u0103r, M.-A., V\u0103c\u0103rescu, C., Morenci, M., Negru, A.-G., Luca, C.-T., and Gai\u021b\u0103, D. (2026). Prognostic Value of Inflammatory Status in Patients with Acute Coronary Syndromes: A Single-Center Experience. J. Clin. Med., 15.","DOI":"10.3390\/jcm15082852"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.15420\/japsc.2021.14","article-title":"NT-proBNP Cut-off Values for Risk Stratification in Acute MI and Comparison with Other Risk Assessment Scores","volume":"1","author":"Tan","year":"2022","journal-title":"J. Asian Pac. Soc. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"ehaf784.1924","DOI":"10.1093\/eurheartj\/ehaf784.1924","article-title":"Persistently Increased NT-pro BNP One Year after Acute Coronary Syndrome: Insights from the SPUM-ACS Registry","volume":"46","author":"Denegri","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pah, A.-M., Craciun, M.-L., Avram, A., Christodorescu, R.M., Popa, D.I., Crisan, S., Vacarescu, C., Mateescu, D.-M., Gavrilescu, D.-M., and Buleu, F. (2026). Pre-Existing Heart Failure, Biomarker Profiles, and Patients\u2019 Vulnerability in Hospitalized COVID-19: A Biomarker-Driven Risk Framework. J. Clin. Med., 15.","DOI":"10.3390\/jcm15051909"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pah, A.-M., Serban, S., Mateescu, D.-M., Cotet, I.-G., Muresan, C.-O., Ilie, A.-C., Buleu, F., Craciun, M.-L., Crisan, S., and Avram, A. (2025). Systemic Inflammatory Biomarkers (Interleukin-6, High-Sensitivity C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio) and Prognosis in Heart Failure: A Meta-Analysis of Prospective Cohort Studies. J. Clin. Med., 14.","DOI":"10.3390\/jcm14238610"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.jchf.2023.06.031","article-title":"Interleukin-6 in Patients with Heart Failure and Preserved Ejection Fraction","volume":"11","author":"Alogna","year":"2023","journal-title":"JACC Heart Fail."},{"key":"ref_23","first-page":"102393","article-title":"Interleukin-6 in Heart Failure with Reduced Ejection Fraction and the Effect of Dapagliflozin","volume":"13","author":"Docherty","year":"2025","journal-title":"Heart Fail."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Esposito, A., Foffa, I., Vecoli, C., Bastiani, L., Berti, S., and Mazzone, A. (2024). The Impact of Acute Heart Failure on Frailty Degree and Outcomes in Elderly Patients with Severe Aortic Stenosis and Chronic Heart Failure with Preserved Ejection Fraction. J. Cardiovasc. Dev. Dis., 11.","DOI":"10.3390\/jcdd11050150"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"xuag193.828","DOI":"10.1093\/ejhf\/xuag193.828","article-title":"Frailty in Acute Cardiac Care and Acute Heart Failure: Prevalence, Prognosis, and Modifiability","volume":"28","author":"Veneziano","year":"2026","journal-title":"Eur. J. Heart Fail."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e05","DOI":"10.15420\/cfr.2024.34","article-title":"Frailty and Heart Failure: Clinical Insights, Patient Outcomes and Future Directions","volume":"11","author":"Mirkowski","year":"2024","journal-title":"Card. Fail. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Garcia, L., Batut, B., Burke, M.L., Kuzak, M., Psomopoulos, F., Arcila, R., Attwood, T.K., Beard, N., Carvalho-Silva, D., and Dimopoulos, A.C. (2020). Ten Simple Rules for Making Training Materials FAIR. PLoS Comput. Biol., 16.","DOI":"10.1371\/journal.pcbi.1007854"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10115","DOI":"10.1038\/s41467-025-66270-1","article-title":"Covid-19 and Cardiovascular Disease in a Total Population-Study of Long-Term Effects, Social Factors and Covid-19-Vaccination","volume":"16","author":"Spetz","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28728","DOI":"10.1038\/s41598-025-14617-5","article-title":"Incidence and Risk Factors of New-Onset Hypertension up to 3 Years Post SARS-CoV-2 Infection","volume":"15","author":"Boparai","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pah, A.-M., Toma, A.-O., Muresan, C.-O., Mateescu, D.-M., Cotet, I.-G., Iancu-Ciorbagiu, L., Ilie, A.-C., Popa, D.I., Gavrilescu, D.-M., and Iurciuc, S. (2026). Combined Burden of Heart Failure and Arterial Hypertension as Predictors of Adverse Outcomes in Hospitalized COVID-19 Patients. J. Clin. Med., 15.","DOI":"10.3390\/jcm15031143"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.hfc.2023.03.002","article-title":"A Review of Heart Failure in Patients with COVID-19","volume":"19","author":"Bashir","year":"2023","journal-title":"Heart Fail. Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/HEARTVIEWS.HEARTVIEWS_122_20","article-title":"COVID-19 and Heart Failure: The Big Challenge","volume":"21","author":"Ata","year":"2020","journal-title":"Heart Views"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Italia, L., Tomasoni, D., Bisegna, S., Pancaldi, E., Stretti, L., Adamo, M., and Metra, M. (2021). COVID-19 and Heart Failure: From Epidemiology During the Pandemic to Myocardial Injury, Myocarditis, and Heart Failure Sequelae. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.713560"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e046820","DOI":"10.1161\/JAHA.125.046820","article-title":"Comorbidity Clusters in Acute Heart Failure: Insights from the AMERICCAASS Registry","volume":"15","author":"Lescano","year":"2026","journal-title":"J. Am. Heart Assoc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/CIRCRESAHA.121.318186","article-title":"Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure","volume":"128","author":"Njoroge","year":"2021","journal-title":"Circ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1573403X09666131117174414","article-title":"Acute Decompensated Heart Failure Update","volume":"11","author":"Teerlink","year":"2015","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4103\/1119-3077.181355","article-title":"High-Risk Pulmonary Embolism in a Patient with Acute Dissecting Aortic Aneurysm","volume":"19","author":"Tudoran","year":"2016","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.repc.2023.03.012","article-title":"The Role of Comorbidities in Acute Heart Failure Outcomes","volume":"42","author":"Braga","year":"2023","journal-title":"Rev. Port. De Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Itani, H., Ennab, M., Moumneh, M.B., Sanayeh, E.B., Moussa, E., Abofrekha, B., Zayed, A., Khayat, O., and Amor, M. (2026). Increased Mortality and Complication Rates in Weekend Admissions for Acute Decompensated Heart Failure: A Five-Year National Study. J. Clin. Med., 15.","DOI":"10.3390\/jcm15062097"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.recesp.2023.10.008","article-title":"Weekend and Holiday Admissions for Decompensated Heart Failure and In-Hospital Mortality. A Cumulative Effect of \u201cNonworking\u201d Days?","volume":"77","author":"Elola","year":"2024","journal-title":"Rev. Espa\u00f1ola De Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJMsa003376","article-title":"Mortality among Patients Admitted to Hospitals on Weekends as Compared with Weekdays","volume":"345","author":"Bell","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.cardfail.2023.08.012","article-title":"The \u201cWeekend Effect\u201d in Patients Admitted with Heart Failure: An Important Gap in Care?","volume":"29","author":"Wong","year":"2023","journal-title":"J. Card. Fail."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Jurado-Arenales, A.M., Rojas-Caballero, M., Ortega, D., Serrano-Garc\u00eda, A.Y., Hurtado-Ortiz, A., Licht-Ardila, M., Manrique-Hern\u00e1ndez, E.F., and Echeverr\u00eda-Correa, L.E. (REC CardioClin., 2026). Impact of depressive symptoms on quality of life in patients with heart failure, REC CardioClin., in press.","DOI":"10.1016\/j.rccl.2026.05.001"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Tudoran, M., Tudoran, C., Ciocarlie, T., and Giurgi-Oncu, C. (2020). Aspects of Diastolic Dysfunction in Patients with New and Recurrent Depression. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228449"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e017174","DOI":"10.1161\/JAHA.120.017174","article-title":"Recurrent Admissions for Acute Decompensated Heart Failure Among Patients with and Without Peripheral Artery Disease: The ARIC Study","volume":"9","author":"Chunawala","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Petrescu, M., V\u0103c\u0103rescu, C., Tudoran, C., Iurciuc, S., and Cozma, D. (2026). Precision Medicine in Heart Failure: Integrating Ventricular\u2013Vascular Interaction and Arterial Stiffness into Patient Phenotyping. J. Clin. Med., 15.","DOI":"10.3390\/jcm15093212"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1161\/ATVBAHA.122.317715","article-title":"Association Between Arterial Stiffness and New-Onset Heart Failure: The Kailuan Study","volume":"43","author":"Zheng","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41371-022-00703-y","article-title":"Association of Arterial Stiffness and Heart Failure with Preserved Ejection Fraction in the Elderly Population\u2014Results from the CARLA Study","volume":"37","author":"Schott","year":"2023","journal-title":"J. Hum. Hypertens."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.3346\/jkms.2024.39.e195","article-title":"Arterial Stiffness and Heart Failure with Preserved Ejection Fraction","volume":"39","author":"Kim","year":"2024","journal-title":"J. Korean Med. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Tudoran, C., Tudoran, M., Giurgi-Oncu, C., Abu-Awwad, A., Abu-Awwad, S.-A., and Voi\u0163\u0103-Mekere\u015f, F. (2023). Associations between Oral Glucose-Lowering Agents and Increased Risk for Life-Threatening Arrhythmias in Patients with Type 2 Diabetes Mellitus\u2014A Literature Review. Medicina, 59.","DOI":"10.3390\/medicina59101760"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Bodea, O.-M., Serban, S., Craciun, M.-L., Mateescu, D.-M., Florescu, E., Muresan, C.-O., Cotet, I.-G., Badalica-Petrescu, M., Munteanu, A., and Velimirovici, D. (2026). Effects of SGLT2 Inhibitors on Clinical Outcomes, Symptoms, Functional Capacity, and Cardiac Remodeling in Heart Failure: A Comprehensive Systematic Review and Multidomain Meta-Analysis of Randomized Trials. J. Clin. Med., 15.","DOI":"10.3390\/jcm15010378"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-L\u00f3pez, A., Regueiro-Abel, M., Johk-Casas, C.A., Vieitez-Fl\u00f3rez, J.M., Elices-Teja, J., Armesto-Rivas, J., Urbano-Seara, G.d., L\u00f3pez-Pena, A.M., \u00c1lvarez-Su\u00e1rez, C.C., and Rois-Gonz\u00e1lez, G. (2026). The Impact of Introducing Sacubitril\/Valsartan and SGLT2 Inhibitors in a Cohort of Patients with Reduced-Ejection-Fraction Heart Failure: A Real-Life Observational Study. J. Clin. Med., 15.","DOI":"10.3390\/jcm15030991"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Ochoa, S.A., Rojas, L.Z., Corona-Arias, C.A., Quiroga-Pico, L.N., Arciniegas-Land\u00ednez, L.V., Serrano-Garc\u00eda, A.Y., Mendoza-Qui\u00f1onez, A.C., Gamboa, K.A., Contreras, A., and Vargas, J.A.H. (2026). GDMT Intensity at Hospital Discharge and Associated Clinical Outcomes in Heart Failure: A Systematic Review and Network Meta-Analysis. J. Clin. Med., 15.","DOI":"10.3390\/jcm15135112"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jurin, I., Lovri\u0107, D., Gjuras, K., Manola, \u0160., Had\u017eibegovi\u0107, I., Udovi\u010di\u0107, M., Rudan, D., Milinkovi\u0107, A., \u0106ati\u0107, J., and Kri\u017eanovi\u0107, M. (2026). Two-Year Implementation, Adherence, and Outcomes of Quadruple Guideline-Directed Medical Therapy in Newly Diagnosed HFrEF: Insights from the Prospective CaRD Registry. J. Clin. Med., 15.","DOI":"10.3390\/jcm15062127"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1186\/s40001-026-04146-w","article-title":"A Retrospective Cohort Study on the Interaction between Arterial Stiffness and Insulin Resistance in Chronic Heart Failure","volume":"31","author":"Ma","year":"2026","journal-title":"Eur. J. Med. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101482","DOI":"10.1016\/j.ijcha.2024.101482","article-title":"Cardiovascular Disease and Covid-19: A Systematic Review","volume":"54","author":"Krishna","year":"2024","journal-title":"IJC Heart Vasc."},{"key":"ref_57","unstructured":"(2026, August 14). COVID-19: What It Means If You Have a Heart Condition. Available online: https:\/\/www.bhf.org.uk\/informationsupport\/heart-matters-magazine\/news\/coronavirus-and-your-health."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11897-024-00649-x","article-title":"Digital Solutions to Optimize Guideline-Directed Medical Therapy Prescriptions in Heart Failure Patients: Current Applications and Future Directions","volume":"21","author":"Man","year":"2024","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Paleckiene, R., Zaliaduonyte, D., Dambrauskiene, V., and Macijauskiene, J. (2024). A Follow-up Program in Patients after Hospitalization for Heart Failure: Long-Term Health Related Quality of Life and Associated Factors. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1358390"},{"key":"ref_60","unstructured":"(2026, August 14). Available online: https:\/\/www.mims.com\/singapore\/disease\/heart-failure-chronic\/follow-up."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ejhf.2008","article-title":"Self-care of Heart Failure Patients: Practical Management Recommendations from the Heart Failure Association of the European Society of Cardiology","volume":"23","author":"Jaarsma","year":"2021","journal-title":"Eur. J. Heart Fail."},{"key":"ref_62","first-page":"308","article-title":"Patient Education and Self-Management for Heart Failure","volume":"5","author":"Sun","year":"2025","journal-title":"Cardiol. Discov."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1093\/eurheartj\/ehaf218","article-title":"Cardiologist Follow-up and Improved Outcomes of Heart Failure: A French Nationwide Cohort","volume":"46","author":"Baudry","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_64","unstructured":"(2026, August 14). 2025 Living with Heart Failure and Managing Advanced HF. Available online: https:\/\/www.heart.org\/en\/health-topics\/heart-failure\/living-with-heart-failure-and-managing-advanced-hf."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e70088","DOI":"10.1111\/cts.70088","article-title":"Long-term Benefit of SGLT2 Inhibitors to Prevent Heart Failure Hospitalization in Patients with Diabetes, with Potential Time-varying Benefit","volume":"17","author":"Takahashi","year":"2024","journal-title":"Clin. Transl. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Crispino, S.P., Segreti, A., Nafisio, V., Valente, D., Crisci, F., Ferro, A., Cavallari, I., Nusca, A., Ussia, G.P., and Grigioni, F. (2025). The Role of SGLT2-Inhibitors Across All Stages of Heart Failure and Mechanisms of Early Clinical Benefit: From Prevention to Advanced Heart Failure. Biomedicines, 13.","DOI":"10.3390\/biomedicines13030608"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Minisy, M.M., and Abdelaziz, A. (2025). The Role of SGLT 2 Inhibitors in Heart Failure with Preserved Ejection Fraction (HFpEF): A Systematic Review and Meta-Analysis of Randomized Controlled Trials. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-05127-3"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1002\/ehf2.14911","article-title":"Optimizing Heart Failure Pathways to Enhance Patient Care: The Program to Optimize Heart Failure Patient Pathways (PRO-HF)","volume":"11","author":"Patwala","year":"2024","journal-title":"ESC Heart Fail."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/eurjpc\/zwaf408","article-title":"Towards a Standardized Diagnostic and Therapeutic Pathway for Suspected Heart Failure with Preserved Ejection Fraction in European Dyspnoea Clinics","volume":"33","author":"Verwerft","year":"2025","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"103352","DOI":"10.1016\/j.cpcardiol.2026.103352","article-title":"Quadruple Therapy in Heart Failure: Why, When, and in Whom?","volume":"51","author":"Paraskevaidis","year":"2026","journal-title":"Curr. Probl. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6624\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:10:30Z","timestamp":1787832630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":70,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15176624"],"URL":"https:\/\/doi.org\/10.3390\/jcm15176624","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}