{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:15:56Z","timestamp":1788066956168,"version":"build-2784847793"},"reference-count":26,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010252","name":"Medical University of Silesia in Katowice, Poland","doi-asserted-by":"crossref","award":["BNW-2-074\/N\/3\/K"],"award-info":[{"award-number":["BNW-2-074\/N\/3\/K"]}],"id":[{"id":"10.13039\/501100010252","id-type":"DOI","asserted-by":"crossref"}]},{"award":["BNW-2-074\/N\/3\/K"],"award-info":[{"award-number":["BNW-2-074\/N\/3\/K"]}],"id":[{"id":"https:\/\/ror.org\/005k7hp45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objective: The EXTRACT registry cohort of 504 patients undergoing transvenous lead extraction (TLE) has been previously reported in terms of periprocedural safety and short-term outcomes. Data on long-term mortality and its predictors in this population remain limited. The study aimed to identify risk factors for overall mortality at three years following TLE. Methods: This is a secondary, long-term follow-up analysis of the previously published EXTRACT registry cohort of 504 consecutive patients who underwent TLE between 2016 and 2022. We conducted a univariate analysis to predict mortality risk following TLE, followed by Cox regression with cross-validation to identify independent predictors of mortality over a 3-year follow-up period; Brier score assessed prediction accuracy for mortality; and decision curve analysis evaluated the clinical usefulness of the model. Results: Mortality data were completed for 487 patients at three-year follow-up. Long-term outcomes of TLE showed that patients with CIED infection (p = 0.0091), higher NYHA class (p &lt; 0.0001), arterial hypertension (p = 0.0068), previous stroke (p = 0.0092), upgraded to condition pacing post-TLE (p = 0.0092), and higher CHA2DS2-VA score (p = 0.0026) had markedly higher mortality at three-year follow-up. Increased mortality was independently associated with estimated glomerular filtration rate (eGFR) and the CHA2DS2-VA score. Risk increased incrementally with each 1 mL\/min\/1.73 m2 decrease in eGFR (hazard ratio, 0.99; 95% CI, 0.98\u20130.99), and each 1-point increase in CHA2DS2-VA conferred a 12% higher mortality rate (hazard ratio, 1.12; 95% CI, 1.02\u20131.23). Conclusions: In this prospective registry, 3-year mortality after TLE was driven predominantly by baseline clinical risk rather than procedural factors. Renal dysfunction and a higher CHA2DS2-VA score independently predicted death, supporting the incorporation of kidney function and global vascular risk into pre-extraction assessment and post-extraction management.<\/jats:p>","DOI":"10.3390\/jcm15176639","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:27:46Z","timestamp":1787920066000},"page":"6639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Mortality Following Transvenous Lead Extraction: Data from EXTRACT Registry"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-8321","authenticated-orcid":false,"given":"Sylwia","family":"G\u0142adysz-Wa\u0144ha","sequence":"first","affiliation":[{"name":"Department of Electrocardiology and Heart Failure, Medical University of Silesia, 40-635 Katowice, Poland"},{"name":"Department of Electrocardiology, Upper Silesian Medical 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-6269","authenticated-orcid":false,"given":"Danuta","family":"\u0141oboda","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology and Heart Failure, Medical University of Silesia, 40-635 Katowice, Poland"},{"name":"Department of Electrocardiology, Upper Silesian Medical Center, Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Joanna","family":"Stacha\u0144czyk","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, Murcki Hospital, 40-749 Katowice, 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