{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:16:58Z","timestamp":1788171418149,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: The Naples Prognostic Score (NPS) is a composite index of nutritional and inflammatory status that has demonstrated prognostic value across various critical illnesses. This study aimed to evaluate the prognostic significance of NPS in patients with acute pancreatitis (AP). Methods: In this retrospective cohort study, 452 patients diagnosed with AP between January 2024 and March 2026 were classified as mild (MAP), moderately severe (MSAP), or severe (SAP) according to the revised Atlanta classification. NPS was calculated from admission serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Results: Of the 452 patients, 276 (61.1%) had MAP, 124 (27.4%) had MSAP, and 52 (11.5%) had SAP. NPS was significantly higher in SAP patients than in MAP and MSAP patients (for both comparisons; p &lt; 0.001). ROC analysis showed an AUC of 0.758 (95% CI: 0.693\u20130.824) for predicting SAP, with an optimal cut-off of NPS \u2265 3 yielding a sensitivity of 80.8% and a specificity of 61.3%. Patients were stratified into low (0\u20132) and high (3\u20134) NPS groups. High NPS was significantly associated with SAP (\u03c72 = 33.044, p &lt; 0.001), with a negative predictive value of 96.1%. In multivariable analysis, high NPS was an independent predictor of SAP (OR: 4.346, 95% CI: 2.018\u20139.362; p &lt; 0.001). Conclusions: NPS, calculated from four routine laboratory parameters available at admission, is a simple, rapid, and independent predictor of disease severity in AP and may support early risk stratification in the emergency setting.<\/jats:p>","DOI":"10.3390\/jcm15176659","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:21:19Z","timestamp":1788168079000},"page":"6659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Value of Naples Prognostic Score in Determining the Prognosis of Acute Pancreatitis\u2014A Single-Center Experience"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-4924","authenticated-orcid":false,"given":"Fatih","family":"Sargin","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Antalya City Hospital, Antalya 07080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-4105","authenticated-orcid":false,"given":"Zeynep","family":"Gok Sargin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Antalya City Hospital, Antalya 07080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3614-2751","authenticated-orcid":false,"given":"Ahmet","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya City Hospital, Antalya 07080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-7818","authenticated-orcid":false,"given":"Ayse","family":"Karaduru Avci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya City Hospital, Antalya 07080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-6171","authenticated-orcid":false,"given":"Celal","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Antalya City Hospital, Antalya 07080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-1012","authenticated-orcid":false,"given":"Ali","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Antalya City Hospital, Antalya 07080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13017-019-0247-0","article-title":"2019 WSES guidelines for the management of severe acute pancreatitis","volume":"14","author":"Tolonen","year":"2019","journal-title":"World J. Emerg. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.3748\/wjg.v29.i37.5268","article-title":"Acute pancreatitis: A review of diagnosis, severity prediction and prognosis assessment from imaging technology, scoring system and artificial intelligence","volume":"29","author":"Hu","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Silva-Vaz, P., Abrantes, A.M., Castelo-Branco, M., Gouveia, A., Botelho, M.F., and Tralh\u00e3o, J.G. (2020). Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010338"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, J., and Zou, J. (2020). Evaluation of four scoring systems in prognostication of acute pancreatitis for elderly patients. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01318-8"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1053\/j.gastro.2012.03.005","article-title":"Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis","volume":"142","author":"Mounzer","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/DCR.0000000000000961","article-title":"Naples Prognostic Score, Based on Nutritional and Inflammatory Status, is an Independent Predictor of Long-term Outcome in Patients Undergoing Surgery for Colorectal Cancer","volume":"60","author":"Galizia","year":"2017","journal-title":"Dis. Colon Rectum"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1080\/14796694.2026.2687698","article-title":"A Naples prognostic score-based nomogram enhances perioperative risk stratification for resected pancreatic cancer","volume":"22","author":"Wu","year":"2026","journal-title":"Future Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13019-026-04011-1","article-title":"Prognostic role of Naples Prognostic Score in lung cancer: A meta-analysis","volume":"21","author":"Liu","year":"2026","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"50658","DOI":"10.31083\/BJHM50658","article-title":"A Combined Inflammatory-Nutritional Index Model for Early Prognosis Prediction in Sepsis: Evidence From Logistic Regression and Decision Curve Analysis","volume":"87","author":"Chen","year":"2026","journal-title":"Br. J. Hosp. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wang, K., Gong, J., Yuan, Z., Wang, R., He, M., Huang, Y., Zhou, J., and Wang, F. (2026). Association of the Naples prognostic score with all-cause and cardiovascular mortality in U.S. patients with heart failure: A retrospective cohort study using NHANES 2001\u20132018. J. Health Popul. Nutr., in press.","DOI":"10.1186\/s41043-026-01352-4"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e70247","DOI":"10.1002\/clc.70247","article-title":"Naples Prognostic Score and Clinical Outcomes After PCI for Acute Coronary Syndrome: A Systematic Review and Meta-Analysis","volume":"49","author":"Ozbay","year":"2026","journal-title":"Clin. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1038\/s41598-026-43811-2","article-title":"Predictive value of the Naples Prognostic Score for rapid kidney function decline in stage 3\u20134 CKD: A multicenter study","volume":"16","author":"Inci","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_13","first-page":"388","article-title":"The value of combining multiple indicators, including inflammation and nutrition, with machine learning for early prediction of severity and short-term prognosis of acute pancreatitis","volume":"26","author":"Zhang","year":"2025","journal-title":"J. Clin. Emerg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4274\/eajem.galenos.2026.27003","article-title":"Comparative Evaluation of Inflammatory, Nutritional and Composite Indices in Acute Pancreatitis","volume":"25","year":"2026","journal-title":"Eurasian J. Emerg. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20142012: Revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1097\/00003246-199510000-00007","article-title":"Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome","volume":"23","author":"Marshall","year":"1995","journal-title":"Crit. Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e20250931","DOI":"10.1590\/1806-9282.20250931","article-title":"The relationship between in-hospital mortality and Naples prognostic score in patients undergoing tricuspid valve surgery","volume":"72","author":"Sevinc","year":"2026","journal-title":"Rev. Assoc. Med. Bras."},{"key":"ref_19","first-page":"e0860","article-title":"Association Between Hypocholesterolemia and Mortality in Critically Ill Patients With Sepsis: A Systematic Review and Meta-Analysis","volume":"5","author":"Hofmaenner","year":"2023","journal-title":"Crit. Care Explor."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5507\/bp.2008.029","article-title":"Hypocholesterolemia in clinically serious conditions\u2014Review","volume":"152","author":"Vyroubal","year":"2008","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech Repub."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clnu.2019.01.022","article-title":"Association of total cholesterol with severe acute pancreatitis: A U-shaped relationship","volume":"39","author":"Hong","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1440-1746.2010.06376.x","article-title":"Nosocomial mortality and early prediction of patients with severe acute pancreatitis","volume":"25","author":"Wang","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Buonacera, A., Stancanelli, B., Colaci, M., and Malatino, L. (2022). Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073636"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Salehi, A.M., Rezaei, R., Sadeghi, A., Ayubi, E., Hasanzarrini, M., Azandaryani, A.R., and Razzaghi, M. (2025). Diagnostic value of neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio and systemic immune-inflammation index for predicting the severity of acute pancreatitis. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-04370-4"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.5152\/tjg.2025.24828","article-title":"Neutrophil-Lymphocyte Ratio and LDH\/Albumin Ratio as Biomarkers for Severity and Mortality in Acute Pancreatitis","volume":"36","author":"Bengi","year":"2025","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhang, L., Cao, X., Wang, B., and Ji, P. (2026). Optimization of modified CT severity index by incorporating lymphocyte-to-monocyte ratio for early stratification in acute pancreatitis: A single-center validation study. Front. Med., 13.","DOI":"10.3389\/fmed.2026.1752594"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Li, X., Zhang, Y., Wang, W., Meng, Y., Chen, H., Chu, G., Li, H., and Qi, X. (2024). An inflammation-based model for identifying severe acute pancreatitis: A single-center retrospective study. BMC Gastroenterol., 24.","DOI":"10.1186\/s12876-024-03148-4"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6659\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:37:16Z","timestamp":1788169036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":27,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15176659"],"URL":"https:\/\/doi.org\/10.3390\/jcm15176659","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}